Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation

Keywords

plasminogen activator, plasminogen activator inhibitor, placentation, angiogenesis, in situ hybridization, TISSUE-TYPE, RHESUS-MONKEY, HORMONAL-REGULATION, CELLS, EXPRESSION, INVOLVEMENT, COMPONENTS, OVULATION, PREGNANCY, INVASION

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation. / Hu, Z Y ; Feng, Q ; Gao, H J et al.
In: Chinese Science Bulletin, Vol. 45, No. 22, 11.2000, p. 2056-2062.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Author

Hu, Z Y ; Feng, Q ; Gao, H J et al. / Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation. In: Chinese Science Bulletin. 2000 ; Vol. 45, No. 22. pp. 2056-2062.

Bibtex

@article{c43a9312deb542cea9a6f4aef9fc15c2,

title = "Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation",

abstract = "The distribution of mRNAs of tissue type (t) and urokinase type (u) plasminogen activator (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) have been studied in the tissues of human first and second trimester placentae by in situ hybridization. The results show that: (i) All the molecules, tPA, uPA, PAI-1 and PAI-2, were identified in the blood vessels, the majority of extravillous trophoblastic cells of the decidual layer between Rohr's and Nitabuch's stria and in the trophoblast cells lining the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (ii) No expression of such probes was observed in the basal and chorionic plate, glandular cells of the decidua, the septal tissues or the villous core mesenchyme. The co-distribution of the molecules observed suggests that the co-ordinated expression of the activators and inhibitors in various cells of the placental tissue may play a role in angiogenesis related to conversion of spiral arteries into utero-placental arteries and establishment of a chorio-decidual blood flow during early stages of placentation.",

keywords = "plasminogen activator, plasminogen activator inhibitor, placentation, angiogenesis, in situ hybridization, TISSUE-TYPE, RHESUS-MONKEY, HORMONAL-REGULATION, CELLS, EXPRESSION, INVOLVEMENT, COMPONENTS, OVULATION, PREGNANCY, INVASION",

author = "Hu, {Z Y} and Q Feng and Gao, {H J} and Ockleford, {C D} and Liu, {Y X}",

year = "2000",

month = nov,

language = "English",

volume = "45",

pages = "2056--2062",

journal = "Chinese Science Bulletin",

issn = "1001-6538",

publisher = "Science in China Press",

number = "22",

}

RIS

TY - JOUR

T1 - Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation

AU - Hu, Z Y

AU - Feng, Q

AU - Gao, H J

AU - Ockleford, C D

AU - Liu, Y X

PY - 2000/11

Y1 - 2000/11

N2 - The distribution of mRNAs of tissue type (t) and urokinase type (u) plasminogen activator (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) have been studied in the tissues of human first and second trimester placentae by in situ hybridization. The results show that: (i) All the molecules, tPA, uPA, PAI-1 and PAI-2, were identified in the blood vessels, the majority of extravillous trophoblastic cells of the decidual layer between Rohr's and Nitabuch's stria and in the trophoblast cells lining the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (ii) No expression of such probes was observed in the basal and chorionic plate, glandular cells of the decidua, the septal tissues or the villous core mesenchyme. The co-distribution of the molecules observed suggests that the co-ordinated expression of the activators and inhibitors in various cells of the placental tissue may play a role in angiogenesis related to conversion of spiral arteries into utero-placental arteries and establishment of a chorio-decidual blood flow during early stages of placentation.

AB - The distribution of mRNAs of tissue type (t) and urokinase type (u) plasminogen activator (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) have been studied in the tissues of human first and second trimester placentae by in situ hybridization. The results show that: (i) All the molecules, tPA, uPA, PAI-1 and PAI-2, were identified in the blood vessels, the majority of extravillous trophoblastic cells of the decidual layer between Rohr's and Nitabuch's stria and in the trophoblast cells lining the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (ii) No expression of such probes was observed in the basal and chorionic plate, glandular cells of the decidua, the septal tissues or the villous core mesenchyme. The co-distribution of the molecules observed suggests that the co-ordinated expression of the activators and inhibitors in various cells of the placental tissue may play a role in angiogenesis related to conversion of spiral arteries into utero-placental arteries and establishment of a chorio-decidual blood flow during early stages of placentation.

KW - plasminogen activator

KW - plasminogen activator inhibitor

KW - placentation

KW - angiogenesis

KW - in situ hybridization

KW - TISSUE-TYPE

KW - RHESUS-MONKEY

KW - HORMONAL-REGULATION

KW - CELLS

KW - EXPRESSION

KW - INVOLVEMENT

KW - COMPONENTS

KW - OVULATION

KW - PREGNANCY

KW - INVASION

M3 - Journal article

VL - 45

SP - 2056

EP - 2062

JO - Chinese Science Bulletin

JF - Chinese Science Bulletin

SN - 1001-6538

IS - 22

ER -

Research

Keywords