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Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China. / Lessler, Justin; Cummings, Derek A. T.; Read, Jonathan M. et al.
In: Nature Communications, Vol. 2, 423, 09.08.2011.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lessler, J, Cummings, DAT, Read, JM, Wang, S, Zhu, H, Smith, GJD, Guan, Y, Jiang, CQ & Riley, S 2011, 'Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China', Nature Communications, vol. 2, 423. https://doi.org/10.1038/ncomms1432

APA

Lessler, J., Cummings, D. A. T., Read, J. M., Wang, S., Zhu, H., Smith, G. J. D., Guan, Y., Jiang, C. Q., & Riley, S. (2011). Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China. Nature Communications, 2, Article 423. https://doi.org/10.1038/ncomms1432

Vancouver

Lessler J, Cummings DAT, Read JM, Wang S, Zhu H, Smith GJD et al. Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China. Nature Communications. 2011 Aug 9;2:423. doi: 10.1038/ncomms1432

Author

Lessler, Justin ; Cummings, Derek A. T. ; Read, Jonathan M. et al. / Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China. In: Nature Communications. 2011 ; Vol. 2.

Bibtex

@article{beba7a3d013c4882a863ab41f09c48ba,
title = "Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China",
abstract = "Variation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain.",
keywords = "SPREAD, VIRUS, EVOLUTION",
author = "Justin Lessler and Cummings, {Derek A. T.} and Read, {Jonathan M.} and Shuying Wang and Huachen Zhu and Smith, {Gavin J. D.} and Yi Guan and Jiang, {Chao Qiang} and Steven Riley",
year = "2011",
month = aug,
day = "9",
doi = "10.1038/ncomms1432",
language = "English",
volume = "2",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China

AU - Lessler, Justin

AU - Cummings, Derek A. T.

AU - Read, Jonathan M.

AU - Wang, Shuying

AU - Zhu, Huachen

AU - Smith, Gavin J. D.

AU - Guan, Yi

AU - Jiang, Chao Qiang

AU - Riley, Steven

PY - 2011/8/9

Y1 - 2011/8/9

N2 - Variation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain.

AB - Variation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain.

KW - SPREAD

KW - VIRUS

KW - EVOLUTION

U2 - 10.1038/ncomms1432

DO - 10.1038/ncomms1432

M3 - Journal article

VL - 2

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 423

ER -