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Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. / Broughton, Susan J; Piper, Matthew D W; Ikeya, Tomoatsu et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 8, 22.02.2005, p. 3105-3110.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Broughton, SJ, Piper, MDW, Ikeya, T, Bass, TM, Jacobson, J, Driege, Y, Martinez, P, Hafen, E, Withers, DJ, Leevers, SJ & Partridge, L 2005, 'Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 8, pp. 3105-3110. https://doi.org/10.1073/pnas.0405775102

APA

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., & Partridge, L. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proceedings of the National Academy of Sciences of the United States of America, 102(8), 3105-3110. https://doi.org/10.1073/pnas.0405775102

Vancouver

Broughton SJ, Piper MDW, Ikeya T, Bass TM, Jacobson J, Driege Y et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proceedings of the National Academy of Sciences of the United States of America. 2005 Feb 22;102(8):3105-3110. doi: 10.1073/pnas.0405775102

Author

Broughton, Susan J ; Piper, Matthew D W ; Ikeya, Tomoatsu et al. / Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 8. pp. 3105-3110.

Bibtex

@article{87fd8d8f6d994886b9c1e3ecad7ac223,
title = "Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands",
abstract = "The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.",
keywords = "Ageing, Carbohydrate Metabolism, Drosophila, Insulin, Lipid Metabolism, Longevity, Oxidative Stress, Starvation",
author = "Broughton, {Susan J} and Piper, {Matthew D W} and Tomoatsu Ikeya and Bass, {Timothy M} and Jake Jacobson and Yasmine Driege and Pedro Martinez and Ernst Hafen and Withers, {Dominic J} and Leevers, {Sally J} and Linda Partridge",
year = "2005",
month = feb,
day = "22",
doi = "10.1073/pnas.0405775102",
language = "English",
volume = "102",
pages = "3105--3110",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "8",

}

RIS

TY - JOUR

T1 - Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

AU - Broughton, Susan J

AU - Piper, Matthew D W

AU - Ikeya, Tomoatsu

AU - Bass, Timothy M

AU - Jacobson, Jake

AU - Driege, Yasmine

AU - Martinez, Pedro

AU - Hafen, Ernst

AU - Withers, Dominic J

AU - Leevers, Sally J

AU - Partridge, Linda

PY - 2005/2/22

Y1 - 2005/2/22

N2 - The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.

AB - The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.

KW - Ageing

KW - Carbohydrate Metabolism

KW - Drosophila

KW - Insulin

KW - Lipid Metabolism

KW - Longevity

KW - Oxidative Stress

KW - Starvation

U2 - 10.1073/pnas.0405775102

DO - 10.1073/pnas.0405775102

M3 - Journal article

C2 - 15708981

VL - 102

SP - 3105

EP - 3110

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 8

ER -