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Longer term stroke risk in intracerebral haemorrhage survivors

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Longer term stroke risk in intracerebral haemorrhage survivors. / CROMIS-2 collaborators.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 91, No. 8, 01.08.2020, p. 840-845.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

CROMIS-2 collaborators 2020, 'Longer term stroke risk in intracerebral haemorrhage survivors', Journal of Neurology, Neurosurgery and Psychiatry, vol. 91, no. 8, pp. 840-845. https://doi.org/10.1136/jnnp-2020-323079

APA

CROMIS-2 collaborators (2020). Longer term stroke risk in intracerebral haemorrhage survivors. Journal of Neurology, Neurosurgery and Psychiatry, 91(8), 840-845. https://doi.org/10.1136/jnnp-2020-323079

Vancouver

CROMIS-2 collaborators. Longer term stroke risk in intracerebral haemorrhage survivors. Journal of Neurology, Neurosurgery and Psychiatry. 2020 Aug 1;91(8):840-845. Epub 2020 Jun 17. doi: 10.1136/jnnp-2020-323079

Author

CROMIS-2 collaborators. / Longer term stroke risk in intracerebral haemorrhage survivors. In: Journal of Neurology, Neurosurgery and Psychiatry. 2020 ; Vol. 91, No. 8. pp. 840-845.

Bibtex

@article{445664f676c24106b2f866b8b5cf3ced,
title = "Longer term stroke risk in intracerebral haemorrhage survivors",
abstract = "OBJECTIVE: To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes.METHODS: We included patients recruited to a UK hospital-based, multicentre observational study of adults with imaging confirmed spontaneous ICH. The outcomes of interest were occurrence of a cerebral ischaemic event (either stroke or transient ischaemic attack) or a further ICH following study entry. Haematoma location was classified as lobar or non-lobar.RESULTS: All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of Microbleeds in Stroke) ICH study were included (mean age 73.3 years; 57.4% male). There were 45 recurrent ICH events (absolute event rate (AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years). Multivariable Cox regression found that lobar ICH was associated with ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p<0.0001); similar results were found in multivariable completing risk analyses. There were 70 cerebral ischaemic events (AER 2.93 per 100 patient-years); 29 in patients presenting with lobar ICH (AER 3.12 per 100 patient-years); and 39 in patients with non-lobar ICH (AER 2.97 per 100 patient-years). Multivariable Cox regression found no association with ICH location (HR 1.13, 95% CI 0.66 to 1.92, p = 0.659). Similar results were seen in completing risk analyses.CONCLUSIONS: In ICH survivors, lobar ICH location was associated with a higher risk of recurrent ICH events than non-lobar ICH; ICH location did not influence risk of subsequent ischaemic events.TRIAL REGISTRATION NUMBER: NCT02513316.",
author = "{CROMIS-2 collaborators} and Gargi Banerjee and Duncan Wilson and Gareth Ambler and Hostettler, {Isabel Charlotte} and Clare Shakeshaft and Hannah Cohen and Tarek Yousry and {Al-Shahi Salman}, Rustam and Lip, {Gregory Y H} and Henry Houlden and Muir, {Keith W} and J{\"a}ger, {Hans Rolf} and Werring, {David J} and Hedley Emsley",
note = "{\textcopyright} Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2020",
month = aug,
day = "1",
doi = "10.1136/jnnp-2020-323079",
language = "English",
volume = "91",
pages = "840--845",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Longer term stroke risk in intracerebral haemorrhage survivors

AU - CROMIS-2 collaborators

AU - Banerjee, Gargi

AU - Wilson, Duncan

AU - Ambler, Gareth

AU - Hostettler, Isabel Charlotte

AU - Shakeshaft, Clare

AU - Cohen, Hannah

AU - Yousry, Tarek

AU - Al-Shahi Salman, Rustam

AU - Lip, Gregory Y H

AU - Houlden, Henry

AU - Muir, Keith W

AU - Jäger, Hans Rolf

AU - Werring, David J

AU - Emsley, Hedley

N1 - © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - OBJECTIVE: To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes.METHODS: We included patients recruited to a UK hospital-based, multicentre observational study of adults with imaging confirmed spontaneous ICH. The outcomes of interest were occurrence of a cerebral ischaemic event (either stroke or transient ischaemic attack) or a further ICH following study entry. Haematoma location was classified as lobar or non-lobar.RESULTS: All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of Microbleeds in Stroke) ICH study were included (mean age 73.3 years; 57.4% male). There were 45 recurrent ICH events (absolute event rate (AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years). Multivariable Cox regression found that lobar ICH was associated with ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p<0.0001); similar results were found in multivariable completing risk analyses. There were 70 cerebral ischaemic events (AER 2.93 per 100 patient-years); 29 in patients presenting with lobar ICH (AER 3.12 per 100 patient-years); and 39 in patients with non-lobar ICH (AER 2.97 per 100 patient-years). Multivariable Cox regression found no association with ICH location (HR 1.13, 95% CI 0.66 to 1.92, p = 0.659). Similar results were seen in completing risk analyses.CONCLUSIONS: In ICH survivors, lobar ICH location was associated with a higher risk of recurrent ICH events than non-lobar ICH; ICH location did not influence risk of subsequent ischaemic events.TRIAL REGISTRATION NUMBER: NCT02513316.

AB - OBJECTIVE: To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes.METHODS: We included patients recruited to a UK hospital-based, multicentre observational study of adults with imaging confirmed spontaneous ICH. The outcomes of interest were occurrence of a cerebral ischaemic event (either stroke or transient ischaemic attack) or a further ICH following study entry. Haematoma location was classified as lobar or non-lobar.RESULTS: All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of Microbleeds in Stroke) ICH study were included (mean age 73.3 years; 57.4% male). There were 45 recurrent ICH events (absolute event rate (AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years). Multivariable Cox regression found that lobar ICH was associated with ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p<0.0001); similar results were found in multivariable completing risk analyses. There were 70 cerebral ischaemic events (AER 2.93 per 100 patient-years); 29 in patients presenting with lobar ICH (AER 3.12 per 100 patient-years); and 39 in patients with non-lobar ICH (AER 2.97 per 100 patient-years). Multivariable Cox regression found no association with ICH location (HR 1.13, 95% CI 0.66 to 1.92, p = 0.659). Similar results were seen in completing risk analyses.CONCLUSIONS: In ICH survivors, lobar ICH location was associated with a higher risk of recurrent ICH events than non-lobar ICH; ICH location did not influence risk of subsequent ischaemic events.TRIAL REGISTRATION NUMBER: NCT02513316.

U2 - 10.1136/jnnp-2020-323079

DO - 10.1136/jnnp-2020-323079

M3 - Journal article

C2 - 32554800

VL - 91

SP - 840

EP - 845

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -