Home > Research > Publications & Outputs > Long-term treatment with olanzapine increases t...

Electronic data

Links

Text available via DOI:

View graph of relations

Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone. / Lasut, Barbara; Palasz, Artur; Filipczyk, Lukasz et al.

In: CNS & neurological disorders drug targets, Vol. 17, No. 6, 2018, p. 458-463.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Lasut, B, Palasz, A, Filipczyk, L, Arias-Carrión, O, Rojczyk, E, Savchyna, M, Bogus, K, Worthington, JJ, Krzystanek, M & Wiaderkiewicz, R 2018, 'Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone', CNS & neurological disorders drug targets, vol. 17, no. 6, pp. 458-463. https://doi.org/10.2174/1871527317666180627113544

APA

Lasut, B., Palasz, A., Filipczyk, L., Arias-Carrión, O., Rojczyk, E., Savchyna, M., Bogus, K., Worthington, J. J., Krzystanek, M., & Wiaderkiewicz, R. (2018). Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone. CNS & neurological disorders drug targets, 17(6), 458-463. https://doi.org/10.2174/1871527317666180627113544

Vancouver

Lasut B, Palasz A, Filipczyk L, Arias-Carrión O, Rojczyk E, Savchyna M et al. Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone. CNS & neurological disorders drug targets. 2018;17(6):458-463. Epub 2018 Jun 26. doi: 10.2174/1871527317666180627113544

Author

Lasut, Barbara ; Palasz, Artur ; Filipczyk, Lukasz et al. / Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone. In: CNS & neurological disorders drug targets. 2018 ; Vol. 17, No. 6. pp. 458-463.

Bibtex

@article{c2d192e0c60d458cbcc986d12f42b988,
title = "Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone",
abstract = "Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells. The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 (Sox-2) and doublecortin (DCX) expressing cells. The results indicate that olanzapine has proneurogenic effects in the adult rat SVZ, as the mean number of sex determining region Y-box 2 (Sox-2) and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone SGZ. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.",
keywords = "Adult neurogenesis, Doublecortin, Mammalian brain, Neuroleptics, Olanzapine, Sex determining region Y-Box 2, aripiprazole, clozapine, doublecortin, glial fibrillary acidic protein, neuroleptic agent, olanzapine, serotonin, transcription factor Sox2, animal experiment, animal model, animal tissue, Article, controlled study, dentate gyrus, dopaminergic nerve cell, hippocampus, immunocytochemistry, immunohistochemistry, male, nervous system development, neural stem cell, neuroblast, nonhuman, protein expression, rat, schizophrenia, subventricular zone",
author = "Barbara Lasut and Artur Palasz and Lukasz Filipczyk and Oscar Arias-Carri{\'o}n and Ewa Rojczyk and Mariia Savchyna and Katarzyna Bogus and Worthington, {John Joseph} and Marek Krzystanek and Ryszard Wiaderkiewicz",
note = "The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1871527317666180627113544",
year = "2018",
doi = "10.2174/1871527317666180627113544",
language = "English",
volume = "17",
pages = "458--463",
journal = "CNS & neurological disorders drug targets",
issn = "1996-3181",
publisher = "Bentham Science Publishers B.V.",
number = "6",

}

RIS

TY - JOUR

T1 - Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone

AU - Lasut, Barbara

AU - Palasz, Artur

AU - Filipczyk, Lukasz

AU - Arias-Carrión, Oscar

AU - Rojczyk, Ewa

AU - Savchyna, Mariia

AU - Bogus, Katarzyna

AU - Worthington, John Joseph

AU - Krzystanek, Marek

AU - Wiaderkiewicz, Ryszard

N1 - The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1871527317666180627113544

PY - 2018

Y1 - 2018

N2 - Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells. The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 (Sox-2) and doublecortin (DCX) expressing cells. The results indicate that olanzapine has proneurogenic effects in the adult rat SVZ, as the mean number of sex determining region Y-box 2 (Sox-2) and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone SGZ. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.

AB - Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells. The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 (Sox-2) and doublecortin (DCX) expressing cells. The results indicate that olanzapine has proneurogenic effects in the adult rat SVZ, as the mean number of sex determining region Y-box 2 (Sox-2) and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone SGZ. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.

KW - Adult neurogenesis

KW - Doublecortin

KW - Mammalian brain

KW - Neuroleptics

KW - Olanzapine

KW - Sex determining region Y-Box 2

KW - aripiprazole

KW - clozapine

KW - doublecortin

KW - glial fibrillary acidic protein

KW - neuroleptic agent

KW - olanzapine

KW - serotonin

KW - transcription factor Sox2

KW - animal experiment

KW - animal model

KW - animal tissue

KW - Article

KW - controlled study

KW - dentate gyrus

KW - dopaminergic nerve cell

KW - hippocampus

KW - immunocytochemistry

KW - immunohistochemistry

KW - male

KW - nervous system development

KW - neural stem cell

KW - neuroblast

KW - nonhuman

KW - protein expression

KW - rat

KW - schizophrenia

KW - subventricular zone

U2 - 10.2174/1871527317666180627113544

DO - 10.2174/1871527317666180627113544

M3 - Journal article

VL - 17

SP - 458

EP - 463

JO - CNS & neurological disorders drug targets

JF - CNS & neurological disorders drug targets

SN - 1996-3181

IS - 6

ER -