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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone
AU - Lasut, Barbara
AU - Palasz, Artur
AU - Filipczyk, Lukasz
AU - Arias-Carrión, Oscar
AU - Rojczyk, Ewa
AU - Savchyna, Mariia
AU - Bogus, Katarzyna
AU - Worthington, John Joseph
AU - Krzystanek, Marek
AU - Wiaderkiewicz, Ryszard
N1 - The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1871527317666180627113544
PY - 2018
Y1 - 2018
N2 - Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells. The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 (Sox-2) and doublecortin (DCX) expressing cells. The results indicate that olanzapine has proneurogenic effects in the adult rat SVZ, as the mean number of sex determining region Y-box 2 (Sox-2) and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone SGZ. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.
AB - Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells. The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 (Sox-2) and doublecortin (DCX) expressing cells. The results indicate that olanzapine has proneurogenic effects in the adult rat SVZ, as the mean number of sex determining region Y-box 2 (Sox-2) and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone SGZ. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.
KW - Adult neurogenesis
KW - Doublecortin
KW - Mammalian brain
KW - Neuroleptics
KW - Olanzapine
KW - Sex determining region Y-Box 2
KW - aripiprazole
KW - clozapine
KW - doublecortin
KW - glial fibrillary acidic protein
KW - neuroleptic agent
KW - olanzapine
KW - serotonin
KW - transcription factor Sox2
KW - animal experiment
KW - animal model
KW - animal tissue
KW - Article
KW - controlled study
KW - dentate gyrus
KW - dopaminergic nerve cell
KW - hippocampus
KW - immunocytochemistry
KW - immunohistochemistry
KW - male
KW - nervous system development
KW - neural stem cell
KW - neuroblast
KW - nonhuman
KW - protein expression
KW - rat
KW - schizophrenia
KW - subventricular zone
U2 - 10.2174/1871527317666180627113544
DO - 10.2174/1871527317666180627113544
M3 - Journal article
VL - 17
SP - 458
EP - 463
JO - CNS & neurological disorders drug targets
JF - CNS & neurological disorders drug targets
SN - 1996-3181
IS - 6
ER -