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Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

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Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate. / Quantock, A J ; Fullwood, N J ; Thonar, E J M A et al.
In: RNIB Eye Contact, Vol. 11, 1997, p. 57-67.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Quantock, AJ, Fullwood, NJ, Thonar, EJMA, Waltman, SR, Capel, MS, Ito, M, Verity, SM & Schanzlin, DJ 1997, 'Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate', RNIB Eye Contact, vol. 11, pp. 57-67.

APA

Quantock, A. J., Fullwood, N. J., Thonar, E. J. M. A., Waltman, S. R., Capel, M. S., Ito, M., Verity, S. M., & Schanzlin, D. J. (1997). Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate. RNIB Eye Contact, 11, 57-67.

Vancouver

Quantock AJ, Fullwood NJ, Thonar EJMA, Waltman SR, Capel MS, Ito M et al. Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate. RNIB Eye Contact. 1997;11:57-67.

Author

Quantock, A J ; Fullwood, N J ; Thonar, E J M A et al. / Macular corneal dystrophy type II : Multiple studies on a cornea with low levels of sulphated keratan sulphate. In: RNIB Eye Contact. 1997 ; Vol. 11. pp. 57-67.

Bibtex

@article{89df40cbd4d6427caa57d19b164e6879,
title = "Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate",
abstract = "We investigated an individual macular corneal dystrophy (MCD) type II cornea from a 42-year-old woman with markedly reduced antigenic keratan sulphate levels, A characteristic 4.6 Angstrom X-ray reflection was evident, and the mid-stroma contained 30% less sulphur than normal. Close packing of collagen was restricted to the superficial stroma, Abnormally large proteoglycan filaments were noted throughout the extracellular matrix and Descemet's membrane's posterior non-banded zone, but not its anterior banded zone. Small, collagen-associated stromal proteoglycans were susceptible to digestion with chondroitinase ABC, but not keratanase I or N-glycanase. On occasion, collagen fibrils ranged in size from 20 mm to 58 nm, with preferential diameters of 34 nm and 42 nm, Corneal guttae were evident, as were numerous endothelial inclusions, most probably due to intracellular fibrillo-granular vacuoles similar to those found in the stroma. The endothelium expressed reduced anti-keratan sulphate labelling.",
keywords = "cornea, macular corneal dystrophy, proteoglycans, glycosaminoglycans, SYNCHROTRON X-RAY, COLLAGEN FIBRILS, SULFATE PROTEOGLYCAN, ELECTRON-MICROSCOPY, DIFFRACTION, STROMA, GLYCOSAMINOGLYCANS, HETEROGENEITY, THICKNESS, CULTURES",
author = "Quantock, {A J} and Fullwood, {N J} and Thonar, {E J M A} and Waltman, {S R} and Capel, {M S} and M Ito and Verity, {S M} and Schanzlin, {D J}",
year = "1997",
language = "English",
volume = "11",
pages = "57--67",
journal = "RNIB Eye Contact",
issn = "0967-8719",

}

RIS

TY - JOUR

T1 - Macular corneal dystrophy type II

T2 - Multiple studies on a cornea with low levels of sulphated keratan sulphate

AU - Quantock, A J

AU - Fullwood, N J

AU - Thonar, E J M A

AU - Waltman, S R

AU - Capel, M S

AU - Ito, M

AU - Verity, S M

AU - Schanzlin, D J

PY - 1997

Y1 - 1997

N2 - We investigated an individual macular corneal dystrophy (MCD) type II cornea from a 42-year-old woman with markedly reduced antigenic keratan sulphate levels, A characteristic 4.6 Angstrom X-ray reflection was evident, and the mid-stroma contained 30% less sulphur than normal. Close packing of collagen was restricted to the superficial stroma, Abnormally large proteoglycan filaments were noted throughout the extracellular matrix and Descemet's membrane's posterior non-banded zone, but not its anterior banded zone. Small, collagen-associated stromal proteoglycans were susceptible to digestion with chondroitinase ABC, but not keratanase I or N-glycanase. On occasion, collagen fibrils ranged in size from 20 mm to 58 nm, with preferential diameters of 34 nm and 42 nm, Corneal guttae were evident, as were numerous endothelial inclusions, most probably due to intracellular fibrillo-granular vacuoles similar to those found in the stroma. The endothelium expressed reduced anti-keratan sulphate labelling.

AB - We investigated an individual macular corneal dystrophy (MCD) type II cornea from a 42-year-old woman with markedly reduced antigenic keratan sulphate levels, A characteristic 4.6 Angstrom X-ray reflection was evident, and the mid-stroma contained 30% less sulphur than normal. Close packing of collagen was restricted to the superficial stroma, Abnormally large proteoglycan filaments were noted throughout the extracellular matrix and Descemet's membrane's posterior non-banded zone, but not its anterior banded zone. Small, collagen-associated stromal proteoglycans were susceptible to digestion with chondroitinase ABC, but not keratanase I or N-glycanase. On occasion, collagen fibrils ranged in size from 20 mm to 58 nm, with preferential diameters of 34 nm and 42 nm, Corneal guttae were evident, as were numerous endothelial inclusions, most probably due to intracellular fibrillo-granular vacuoles similar to those found in the stroma. The endothelium expressed reduced anti-keratan sulphate labelling.

KW - cornea

KW - macular corneal dystrophy

KW - proteoglycans

KW - glycosaminoglycans

KW - SYNCHROTRON X-RAY

KW - COLLAGEN FIBRILS

KW - SULFATE PROTEOGLYCAN

KW - ELECTRON-MICROSCOPY

KW - DIFFRACTION

KW - STROMA

KW - GLYCOSAMINOGLYCANS

KW - HETEROGENEITY

KW - THICKNESS

KW - CULTURES

M3 - Journal article

VL - 11

SP - 57

EP - 67

JO - RNIB Eye Contact

JF - RNIB Eye Contact

SN - 0967-8719

ER -