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Maintenance of distinct melanocyte populations in the interfollicular epidermis

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Maintenance of distinct melanocyte populations in the interfollicular epidermis. / Glover, James D.; Knolle, Stefan; Wells, Kirsty L. et al.
In: Pigment Cell and Melanoma Research, Vol. 28, No. 4, 07.2015, p. 476-480.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Glover, JD, Knolle, S, Wells, KL, Liu, D, Jackson, IJ, Mort, RL & Headon, DJ 2015, 'Maintenance of distinct melanocyte populations in the interfollicular epidermis', Pigment Cell and Melanoma Research, vol. 28, no. 4, pp. 476-480. https://doi.org/10.1111/pcmr.12375

APA

Glover, J. D., Knolle, S., Wells, K. L., Liu, D., Jackson, I. J., Mort, R. L., & Headon, D. J. (2015). Maintenance of distinct melanocyte populations in the interfollicular epidermis. Pigment Cell and Melanoma Research, 28(4), 476-480. https://doi.org/10.1111/pcmr.12375

Vancouver

Glover JD, Knolle S, Wells KL, Liu D, Jackson IJ, Mort RL et al. Maintenance of distinct melanocyte populations in the interfollicular epidermis. Pigment Cell and Melanoma Research. 2015 Jul;28(4):476-480. Epub 2015 Apr 30. doi: 10.1111/pcmr.12375

Author

Glover, James D. ; Knolle, Stefan ; Wells, Kirsty L. et al. / Maintenance of distinct melanocyte populations in the interfollicular epidermis. In: Pigment Cell and Melanoma Research. 2015 ; Vol. 28, No. 4. pp. 476-480.

Bibtex

@article{f116e732bddc4fcb84a8a2f8fa04bc7b,
title = "Maintenance of distinct melanocyte populations in the interfollicular epidermis",
abstract = "Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs do not produce melanin. They serve as a source of differentiated melanocytes for the hair follicle and contribute to the interfollicular epidermis upon wounding, exposure to ultraviolet irradiation or in remission from vitiligo, where repigmentation often spreads outwards from the hair follicles. It is unknown whether these observations reflect the normal homoeostatic mechanism of melanocyte renewal or whether unperturbed interfollicular epidermis can maintain a melanocyte population that is independent of the skin's appendages. Here, we show that mouse tail skin lacking appendages does maintain a stable melanocyte number, including a low frequency of amelanotic melanocytes, into adult life. Furthermore, we show that actively cycling differentiated melanocytes are present in postnatal skin, indicating that amelanotic melanocytes are not uniquely relied on for melanocyte homoeostasis.",
keywords = "Animals, Cell Division, Epidermis, Hair Follicle, Humans, Melanins, Melanocytes, Mice, Journal Article, Research Support, Non-U.S. Gov't",
author = "Glover, {James D.} and Stefan Knolle and Wells, {Kirsty L.} and Dianbo Liu and Jackson, {Ian J.} and Mort, {Richard L.} and Headon, {Denis J.}",
note = "{\textcopyright} 2015 The Authors. Pigment Cell & Melanoma Research Published by John Wiley & Sons Ltd.",
year = "2015",
month = jul,
doi = "10.1111/pcmr.12375",
language = "English",
volume = "28",
pages = "476--480",
journal = "Pigment Cell and Melanoma Research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Maintenance of distinct melanocyte populations in the interfollicular epidermis

AU - Glover, James D.

AU - Knolle, Stefan

AU - Wells, Kirsty L.

AU - Liu, Dianbo

AU - Jackson, Ian J.

AU - Mort, Richard L.

AU - Headon, Denis J.

N1 - © 2015 The Authors. Pigment Cell & Melanoma Research Published by John Wiley & Sons Ltd.

PY - 2015/7

Y1 - 2015/7

N2 - Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs do not produce melanin. They serve as a source of differentiated melanocytes for the hair follicle and contribute to the interfollicular epidermis upon wounding, exposure to ultraviolet irradiation or in remission from vitiligo, where repigmentation often spreads outwards from the hair follicles. It is unknown whether these observations reflect the normal homoeostatic mechanism of melanocyte renewal or whether unperturbed interfollicular epidermis can maintain a melanocyte population that is independent of the skin's appendages. Here, we show that mouse tail skin lacking appendages does maintain a stable melanocyte number, including a low frequency of amelanotic melanocytes, into adult life. Furthermore, we show that actively cycling differentiated melanocytes are present in postnatal skin, indicating that amelanotic melanocytes are not uniquely relied on for melanocyte homoeostasis.

AB - Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs do not produce melanin. They serve as a source of differentiated melanocytes for the hair follicle and contribute to the interfollicular epidermis upon wounding, exposure to ultraviolet irradiation or in remission from vitiligo, where repigmentation often spreads outwards from the hair follicles. It is unknown whether these observations reflect the normal homoeostatic mechanism of melanocyte renewal or whether unperturbed interfollicular epidermis can maintain a melanocyte population that is independent of the skin's appendages. Here, we show that mouse tail skin lacking appendages does maintain a stable melanocyte number, including a low frequency of amelanotic melanocytes, into adult life. Furthermore, we show that actively cycling differentiated melanocytes are present in postnatal skin, indicating that amelanotic melanocytes are not uniquely relied on for melanocyte homoeostasis.

KW - Animals

KW - Cell Division

KW - Epidermis

KW - Hair Follicle

KW - Humans

KW - Melanins

KW - Melanocytes

KW - Mice

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/pcmr.12375

DO - 10.1111/pcmr.12375

M3 - Journal article

C2 - 25847135

VL - 28

SP - 476

EP - 480

JO - Pigment Cell and Melanoma Research

JF - Pigment Cell and Melanoma Research

SN - 1755-1471

IS - 4

ER -