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Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.)

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.). / Paterson, S.; Wilson, K.; Pemberton, J. M.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 7, 31.03.1998, p. 3714-3719.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Paterson, S, Wilson, K & Pemberton, JM 1998, 'Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.)', Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 7, pp. 3714-3719. https://doi.org/10.1073/pnas.95.7.3714

APA

Paterson, S., Wilson, K., & Pemberton, J. M. (1998). Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.). Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3714-3719. https://doi.org/10.1073/pnas.95.7.3714

Vancouver

Paterson S, Wilson K, Pemberton JM. Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.). Proceedings of the National Academy of Sciences of the United States of America. 1998 Mar 31;95(7):3714-3719. doi: 10.1073/pnas.95.7.3714

Author

Paterson, S. ; Wilson, K. ; Pemberton, J. M. / Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.). In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 7. pp. 3714-3719.

Bibtex

@article{0fc88ceb588b4218bca395939dc13647,
title = "Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.)",
abstract = "Antagonistic coevolution between hosts and parasites has been proposed as a mechanism maintaining genetic diversity in both host and parasite populations. In particular, the high levels of genetic diversity widely observed at the major histocompatibility complex (MHC) of vertebrate hosts are consistent with the hypothesis of parasite-driven balancing selection acting to maintain MHC genetic diversity. To date, however, empirical evidence in support of this hypothesis, especially from natural populations, has been lacking. A large unmanaged population of Soay sheep (Ovis aries L.) is used to investigate associations between MHC variation, juvenile survival, and parasite resistance. We show in an unmanaged, nonhuman population that allelic variation within the MHC is significantly associated with differences in both juvenile survival and resistance to intestinal nematodes. Certain MHC alleles are associated with low survivorship probabilities and high levels of parasitism or vice versa. We conclude that parasites are likely to play a major role in the maintenance of MHC diversity in this population.",
keywords = "Genetic diversity, Helminth parasites, Red Queen, Selection",
author = "S. Paterson and K. Wilson and Pemberton, {J. M.}",
year = "1998",
month = mar,
day = "31",
doi = "10.1073/pnas.95.7.3714",
language = "English",
volume = "95",
pages = "3714--3719",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "7",

}

RIS

TY - JOUR

T1 - Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.)

AU - Paterson, S.

AU - Wilson, K.

AU - Pemberton, J. M.

PY - 1998/3/31

Y1 - 1998/3/31

N2 - Antagonistic coevolution between hosts and parasites has been proposed as a mechanism maintaining genetic diversity in both host and parasite populations. In particular, the high levels of genetic diversity widely observed at the major histocompatibility complex (MHC) of vertebrate hosts are consistent with the hypothesis of parasite-driven balancing selection acting to maintain MHC genetic diversity. To date, however, empirical evidence in support of this hypothesis, especially from natural populations, has been lacking. A large unmanaged population of Soay sheep (Ovis aries L.) is used to investigate associations between MHC variation, juvenile survival, and parasite resistance. We show in an unmanaged, nonhuman population that allelic variation within the MHC is significantly associated with differences in both juvenile survival and resistance to intestinal nematodes. Certain MHC alleles are associated with low survivorship probabilities and high levels of parasitism or vice versa. We conclude that parasites are likely to play a major role in the maintenance of MHC diversity in this population.

AB - Antagonistic coevolution between hosts and parasites has been proposed as a mechanism maintaining genetic diversity in both host and parasite populations. In particular, the high levels of genetic diversity widely observed at the major histocompatibility complex (MHC) of vertebrate hosts are consistent with the hypothesis of parasite-driven balancing selection acting to maintain MHC genetic diversity. To date, however, empirical evidence in support of this hypothesis, especially from natural populations, has been lacking. A large unmanaged population of Soay sheep (Ovis aries L.) is used to investigate associations between MHC variation, juvenile survival, and parasite resistance. We show in an unmanaged, nonhuman population that allelic variation within the MHC is significantly associated with differences in both juvenile survival and resistance to intestinal nematodes. Certain MHC alleles are associated with low survivorship probabilities and high levels of parasitism or vice versa. We conclude that parasites are likely to play a major role in the maintenance of MHC diversity in this population.

KW - Genetic diversity

KW - Helminth parasites

KW - Red Queen

KW - Selection

U2 - 10.1073/pnas.95.7.3714

DO - 10.1073/pnas.95.7.3714

M3 - Journal article

C2 - 9520432

AN - SCOPUS:0032584199

VL - 95

SP - 3714

EP - 3719

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 7

ER -