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Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria.

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Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria. / Vendeville, Agnès; Winzer, Klaus; Heurlier, Karin et al.
In: Nature Reviews in Microbiology, Vol. 3, No. 5, 05.2005, p. 383-396.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Vendeville, A, Winzer, K, Heurlier, K, Tang, CM & Hardie, KR 2005, 'Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria.', Nature Reviews in Microbiology, vol. 3, no. 5, pp. 383-396. https://doi.org/10.1038/nrmicro1146

APA

Vendeville, A., Winzer, K., Heurlier, K., Tang, C. M., & Hardie, K. R. (2005). Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria. Nature Reviews in Microbiology, 3(5), 383-396. https://doi.org/10.1038/nrmicro1146

Vancouver

Vendeville A, Winzer K, Heurlier K, Tang CM, Hardie KR. Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria. Nature Reviews in Microbiology. 2005 May;3(5):383-396. doi: 10.1038/nrmicro1146

Author

Vendeville, Agnès ; Winzer, Klaus ; Heurlier, Karin et al. / Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria. In: Nature Reviews in Microbiology. 2005 ; Vol. 3, No. 5. pp. 383-396.

Bibtex

@article{418e313e3ff0420fa212c5fd46426fc6,
title = "Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria.",
abstract = "Bacteria exploit many mechanisms to communicate with each other and their surroundings. Mechanisms using small diffusible signals to coordinate behaviour with cell density (quorum sensing) frequently contribute to pathogenicity. However, pathogens must also be able to acquire nutrients and replicate to successfully invade their host. One quorum-sensing system, based on the possession of LuxS, bears the unique feature of contributing directly to metabolism, and therefore has the potential to influence both gene regulation and bacterial fitness. Here, we discuss the influence that LuxS and its product, autoinducer-2, have on virulence, relating the current evidence to the preferred niche of the pathogen and the underlying mechanisms involved.",
author = "Agn{\`e}s Vendeville and Klaus Winzer and Karin Heurlier and Tang, {Christoph M.} and Hardie, {Kim R.}",
year = "2005",
month = may,
doi = "10.1038/nrmicro1146",
language = "English",
volume = "3",
pages = "383--396",
journal = "Nature Reviews in Microbiology",
issn = "1740-1534",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria.

AU - Vendeville, Agnès

AU - Winzer, Klaus

AU - Heurlier, Karin

AU - Tang, Christoph M.

AU - Hardie, Kim R.

PY - 2005/5

Y1 - 2005/5

N2 - Bacteria exploit many mechanisms to communicate with each other and their surroundings. Mechanisms using small diffusible signals to coordinate behaviour with cell density (quorum sensing) frequently contribute to pathogenicity. However, pathogens must also be able to acquire nutrients and replicate to successfully invade their host. One quorum-sensing system, based on the possession of LuxS, bears the unique feature of contributing directly to metabolism, and therefore has the potential to influence both gene regulation and bacterial fitness. Here, we discuss the influence that LuxS and its product, autoinducer-2, have on virulence, relating the current evidence to the preferred niche of the pathogen and the underlying mechanisms involved.

AB - Bacteria exploit many mechanisms to communicate with each other and their surroundings. Mechanisms using small diffusible signals to coordinate behaviour with cell density (quorum sensing) frequently contribute to pathogenicity. However, pathogens must also be able to acquire nutrients and replicate to successfully invade their host. One quorum-sensing system, based on the possession of LuxS, bears the unique feature of contributing directly to metabolism, and therefore has the potential to influence both gene regulation and bacterial fitness. Here, we discuss the influence that LuxS and its product, autoinducer-2, have on virulence, relating the current evidence to the preferred niche of the pathogen and the underlying mechanisms involved.

U2 - 10.1038/nrmicro1146

DO - 10.1038/nrmicro1146

M3 - Journal article

VL - 3

SP - 383

EP - 396

JO - Nature Reviews in Microbiology

JF - Nature Reviews in Microbiology

SN - 1740-1534

IS - 5

ER -