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Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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  • D Katie Wilkinson
  • E Jane Turner
  • Edward T Parkin
  • Ashley E Garner
  • Penny J Harrison
  • Mark Crawford
  • Gordon W Stewart
  • Nigel M Hooper
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<mark>Journal publication date</mark>01/2008
<mark>Journal</mark>Biochimica et Biophysica Acta (BBA) - Biomembranes
Issue number1
Volume1778
Number of pages8
Pages (from-to)125-132
Publication StatusPublished
<mark>Original language</mark>English

Abstract

In overhydrated hereditary stomatocytosis (OHSt), the membrane raft-associated stomatin is deficient from the erythrocyte membrane. We have investigated two aspects of raft structure and function in OHSt erythrocytes. First, we have studied the distribution of other membrane and cytoskeletal proteins in rafts by analysis of detergent-resistant membranes (DRMs). In normal erythrocytes, 29% of the actin was DRM-associated, whereas in two unrelated OHSt patients the DRM-associated actin was reduced to