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    Rights statement: © 2011 Stanton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Meningococcal disease in children in Merseyside, England: a 31 year descriptive study

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Meningococcal disease in children in Merseyside, England : a 31 year descriptive study. / Stanton, Michelle C.; Taylor-Robinson, David; Harris, David; Paize, Fauzia; Makwana, Nick; Hackett, Scott J.; Baines, Paul B.; Riordan, F. Andrew I.; Marzouk, Omnia; Thomson, Alistair P. J.; Diggle, Peter J.; Hart, C. Anthony; Carrol, Enitan D.

In: PLoS ONE, Vol. 6, No. 10, e25957, 07.10.2011, p. -.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Stanton, MC, Taylor-Robinson, D, Harris, D, Paize, F, Makwana, N, Hackett, SJ, Baines, PB, Riordan, FAI, Marzouk, O, Thomson, APJ, Diggle, PJ, Hart, CA & Carrol, ED 2011, 'Meningococcal disease in children in Merseyside, England: a 31 year descriptive study', PLoS ONE, vol. 6, no. 10, e25957, pp. -. https://doi.org/10.1371/journal.pone.0025957

APA

Stanton, M. C., Taylor-Robinson, D., Harris, D., Paize, F., Makwana, N., Hackett, S. J., Baines, P. B., Riordan, F. A. I., Marzouk, O., Thomson, A. P. J., Diggle, P. J., Hart, C. A., & Carrol, E. D. (2011). Meningococcal disease in children in Merseyside, England: a 31 year descriptive study. PLoS ONE, 6(10), -. [e25957]. https://doi.org/10.1371/journal.pone.0025957

Vancouver

Stanton MC, Taylor-Robinson D, Harris D, Paize F, Makwana N, Hackett SJ et al. Meningococcal disease in children in Merseyside, England: a 31 year descriptive study. PLoS ONE. 2011 Oct 7;6(10):-. e25957. https://doi.org/10.1371/journal.pone.0025957

Author

Stanton, Michelle C. ; Taylor-Robinson, David ; Harris, David ; Paize, Fauzia ; Makwana, Nick ; Hackett, Scott J. ; Baines, Paul B. ; Riordan, F. Andrew I. ; Marzouk, Omnia ; Thomson, Alistair P. J. ; Diggle, Peter J. ; Hart, C. Anthony ; Carrol, Enitan D. / Meningococcal disease in children in Merseyside, England : a 31 year descriptive study. In: PLoS ONE. 2011 ; Vol. 6, No. 10. pp. -.

Bibtex

@article{f333992993264bb494b2188a5c19c7b3,
title = "Meningococcal disease in children in Merseyside, England: a 31 year descriptive study",
abstract = "Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD.",
keywords = "MORTALITY, DEPRIVATION, CONFIRMATION, EPIDEMIOLOGY",
author = "Stanton, {Michelle C.} and David Taylor-Robinson and David Harris and Fauzia Paize and Nick Makwana and Hackett, {Scott J.} and Baines, {Paul B.} and Riordan, {F. Andrew I.} and Omnia Marzouk and Thomson, {Alistair P. J.} and Diggle, {Peter J.} and Hart, {C. Anthony} and Carrol, {Enitan D.}",
note = "{\textcopyright} 2011 Stanton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2011",
month = oct,
day = "7",
doi = "10.1371/journal.pone.0025957",
language = "English",
volume = "6",
pages = "--",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Meningococcal disease in children in Merseyside, England

T2 - a 31 year descriptive study

AU - Stanton, Michelle C.

AU - Taylor-Robinson, David

AU - Harris, David

AU - Paize, Fauzia

AU - Makwana, Nick

AU - Hackett, Scott J.

AU - Baines, Paul B.

AU - Riordan, F. Andrew I.

AU - Marzouk, Omnia

AU - Thomson, Alistair P. J.

AU - Diggle, Peter J.

AU - Hart, C. Anthony

AU - Carrol, Enitan D.

N1 - © 2011 Stanton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2011/10/7

Y1 - 2011/10/7

N2 - Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD.

AB - Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD.

KW - MORTALITY

KW - DEPRIVATION

KW - CONFIRMATION

KW - EPIDEMIOLOGY

U2 - 10.1371/journal.pone.0025957

DO - 10.1371/journal.pone.0025957

M3 - Journal article

VL - 6

SP - -

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

M1 - e25957

ER -