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    Rights statement: 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Microbes, molecular mimicry and molecules of mood and motivation

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Microbes, molecular mimicry and molecules of mood and motivation. / Morris, James; Broughton, Susan Jane; Wessels, Quenton Bester.
In: Medical Hypotheses, Vol. 87, 02.2016, p. 40-43.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Morris, J, Broughton, SJ & Wessels, QB 2016, 'Microbes, molecular mimicry and molecules of mood and motivation', Medical Hypotheses, vol. 87, pp. 40-43. https://doi.org/10.1016/j.mehy.2015.12.011

APA

Morris, J., Broughton, S. J., & Wessels, Q. B. (2016). Microbes, molecular mimicry and molecules of mood and motivation. Medical Hypotheses, 87, 40-43. https://doi.org/10.1016/j.mehy.2015.12.011

Vancouver

Morris J, Broughton SJ, Wessels QB. Microbes, molecular mimicry and molecules of mood and motivation. Medical Hypotheses. 2016 Feb;87:40-43. Epub 2015 Dec 17. doi: 10.1016/j.mehy.2015.12.011

Author

Morris, James ; Broughton, Susan Jane ; Wessels, Quenton Bester. / Microbes, molecular mimicry and molecules of mood and motivation. In: Medical Hypotheses. 2016 ; Vol. 87. pp. 40-43.

Bibtex

@article{2bfc5b531feb498ea9750fc8ad16fb14,
title = "Microbes, molecular mimicry and molecules of mood and motivation",
abstract = "The hypothesis proposed is that functional disorders, such as irritable bowel syndrome, chronic fatigue syndrome and anorexia nervosa are caused by auto-antibodies to neuronal proteins induced by molecular mimicry with microbial antigens. The age incidence of these conditions, the marked female excess, increase with economic and technological advance, precipitation by infection, and the paucity of histological changes are all consistent with the hypothesis. It can be tested directly using human sera to search for cross reaction with brain proteins in model systems such as Drosophila melanogaster. The conditions might be amenable to treatment using pooled immunoglobulin. Identification and elimination from the microbial flora of the bacteria that express the cross reacting antigens should be possible.",
author = "James Morris and Broughton, {Susan Jane} and Wessels, {Quenton Bester}",
note = " 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",
year = "2016",
month = feb,
doi = "10.1016/j.mehy.2015.12.011",
language = "English",
volume = "87",
pages = "40--43",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - Microbes, molecular mimicry and molecules of mood and motivation

AU - Morris, James

AU - Broughton, Susan Jane

AU - Wessels, Quenton Bester

N1 - 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PY - 2016/2

Y1 - 2016/2

N2 - The hypothesis proposed is that functional disorders, such as irritable bowel syndrome, chronic fatigue syndrome and anorexia nervosa are caused by auto-antibodies to neuronal proteins induced by molecular mimicry with microbial antigens. The age incidence of these conditions, the marked female excess, increase with economic and technological advance, precipitation by infection, and the paucity of histological changes are all consistent with the hypothesis. It can be tested directly using human sera to search for cross reaction with brain proteins in model systems such as Drosophila melanogaster. The conditions might be amenable to treatment using pooled immunoglobulin. Identification and elimination from the microbial flora of the bacteria that express the cross reacting antigens should be possible.

AB - The hypothesis proposed is that functional disorders, such as irritable bowel syndrome, chronic fatigue syndrome and anorexia nervosa are caused by auto-antibodies to neuronal proteins induced by molecular mimicry with microbial antigens. The age incidence of these conditions, the marked female excess, increase with economic and technological advance, precipitation by infection, and the paucity of histological changes are all consistent with the hypothesis. It can be tested directly using human sera to search for cross reaction with brain proteins in model systems such as Drosophila melanogaster. The conditions might be amenable to treatment using pooled immunoglobulin. Identification and elimination from the microbial flora of the bacteria that express the cross reacting antigens should be possible.

U2 - 10.1016/j.mehy.2015.12.011

DO - 10.1016/j.mehy.2015.12.011

M3 - Journal article

VL - 87

SP - 40

EP - 43

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

ER -