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Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes?

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes? / Ockleford, C; Bright, N; Hubbard, A et al.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 342, No. 1300, 29.10.1993, p. 121-36.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Ockleford, C, Bright, N, Hubbard, A, D'Lacey, C, Smith, J, Gardiner, L, Sheikh, T, Albentosa, M & Turtle, K 1993, 'Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes?', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 342, no. 1300, pp. 121-36. https://doi.org/10.1098/rstb.1993.0142

APA

Ockleford, C., Bright, N., Hubbard, A., D'Lacey, C., Smith, J., Gardiner, L., Sheikh, T., Albentosa, M., & Turtle, K. (1993). Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes? Philosophical Transactions of the Royal Society B: Biological Sciences, 342(1300), 121-36. https://doi.org/10.1098/rstb.1993.0142

Vancouver

Ockleford C, Bright N, Hubbard A, D'Lacey C, Smith J, Gardiner L et al. Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes? Philosophical Transactions of the Royal Society B: Biological Sciences. 1993 Oct 29;342(1300):121-36. doi: 10.1098/rstb.1993.0142

Author

Ockleford, C ; Bright, N ; Hubbard, A et al. / Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes?. In: Philosophical Transactions of the Royal Society B: Biological Sciences. 1993 ; Vol. 342, No. 1300. pp. 121-36.

Bibtex

@article{1f5997be43464f6982a41d85feb6d6b1,
title = "Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes?",
abstract = "Immunocytochemical confocal laser scanning microscopy and ultrastructural analysis, including immunoelectron microscopy, reveals the distribution of structures in human term amniochorion similar in some respects to basement membranes but with unusually restricted dimensions. On the basis of their immunoreactivity, these trabecular structures, found on the fibroblast layer side of the spongy layer of human term amniochorion and adjacent reticular layer, have been shown to contain type IV collagen, laminin, and nidogen. The origin of these components may be from primitive epithelial structures which pumped fluid into the lakes that eventually coalesced to form the extraembryonic coelom separating the extraembryonic somatic mesoderm from the extraembryonic splanchnic mesoderm. Such a theory of their origin might link them with the mysterious 'cellular layer', a single-cell-thick layer of cells which is usually no longer present in fetal membranes at term. The similarity in composition but not in size of these structures to anchoring plaques for type VII collagen is possible support for the view that these structures are integrators of extracellular matrix polymeric proteins. The 'pseudobasement' membrane associated with the trophoblast layer, on investigation, appears to be typical by six criteria. 'Coiled' fibrous structures in the extracellular matrix of the spongy layer may aid adjustments under tension at this shear surface by a detachable 'Velcro' or 'two spring' fastening system. The coils are rich in fibronectin. The suggestion is made that the compact layer is a giant lamina reticularis associated with the amniotic epithelial basement membrane.",
keywords = "Basement Membrane/ultrastructure, Collagen/analysis, Extraembryonic Membranes/cytology, Female, Fibronectins/analysis, Fluorescent Antibody Technique, Humans, Immunohistochemistry, Laminin/analysis, Mesoderm, Microscopy, Electron, Scanning, Microscopy, Fluorescence, Pregnancy",
author = "C Ockleford and N Bright and A Hubbard and C D'Lacey and J Smith and L Gardiner and T Sheikh and M Albentosa and K Turtle",
year = "1993",
month = oct,
day = "29",
doi = "10.1098/rstb.1993.0142",
language = "English",
volume = "342",
pages = "121--36",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "0962-8436",
publisher = "Royal Society",
number = "1300",

}

RIS

TY - JOUR

T1 - Micro-trabeculae, macro-plaques or mini-basement membranes in human term fetal membranes?

AU - Ockleford, C

AU - Bright, N

AU - Hubbard, A

AU - D'Lacey, C

AU - Smith, J

AU - Gardiner, L

AU - Sheikh, T

AU - Albentosa, M

AU - Turtle, K

PY - 1993/10/29

Y1 - 1993/10/29

N2 - Immunocytochemical confocal laser scanning microscopy and ultrastructural analysis, including immunoelectron microscopy, reveals the distribution of structures in human term amniochorion similar in some respects to basement membranes but with unusually restricted dimensions. On the basis of their immunoreactivity, these trabecular structures, found on the fibroblast layer side of the spongy layer of human term amniochorion and adjacent reticular layer, have been shown to contain type IV collagen, laminin, and nidogen. The origin of these components may be from primitive epithelial structures which pumped fluid into the lakes that eventually coalesced to form the extraembryonic coelom separating the extraembryonic somatic mesoderm from the extraembryonic splanchnic mesoderm. Such a theory of their origin might link them with the mysterious 'cellular layer', a single-cell-thick layer of cells which is usually no longer present in fetal membranes at term. The similarity in composition but not in size of these structures to anchoring plaques for type VII collagen is possible support for the view that these structures are integrators of extracellular matrix polymeric proteins. The 'pseudobasement' membrane associated with the trophoblast layer, on investigation, appears to be typical by six criteria. 'Coiled' fibrous structures in the extracellular matrix of the spongy layer may aid adjustments under tension at this shear surface by a detachable 'Velcro' or 'two spring' fastening system. The coils are rich in fibronectin. The suggestion is made that the compact layer is a giant lamina reticularis associated with the amniotic epithelial basement membrane.

AB - Immunocytochemical confocal laser scanning microscopy and ultrastructural analysis, including immunoelectron microscopy, reveals the distribution of structures in human term amniochorion similar in some respects to basement membranes but with unusually restricted dimensions. On the basis of their immunoreactivity, these trabecular structures, found on the fibroblast layer side of the spongy layer of human term amniochorion and adjacent reticular layer, have been shown to contain type IV collagen, laminin, and nidogen. The origin of these components may be from primitive epithelial structures which pumped fluid into the lakes that eventually coalesced to form the extraembryonic coelom separating the extraembryonic somatic mesoderm from the extraembryonic splanchnic mesoderm. Such a theory of their origin might link them with the mysterious 'cellular layer', a single-cell-thick layer of cells which is usually no longer present in fetal membranes at term. The similarity in composition but not in size of these structures to anchoring plaques for type VII collagen is possible support for the view that these structures are integrators of extracellular matrix polymeric proteins. The 'pseudobasement' membrane associated with the trophoblast layer, on investigation, appears to be typical by six criteria. 'Coiled' fibrous structures in the extracellular matrix of the spongy layer may aid adjustments under tension at this shear surface by a detachable 'Velcro' or 'two spring' fastening system. The coils are rich in fibronectin. The suggestion is made that the compact layer is a giant lamina reticularis associated with the amniotic epithelial basement membrane.

KW - Basement Membrane/ultrastructure

KW - Collagen/analysis

KW - Extraembryonic Membranes/cytology

KW - Female

KW - Fibronectins/analysis

KW - Fluorescent Antibody Technique

KW - Humans

KW - Immunohistochemistry

KW - Laminin/analysis

KW - Mesoderm

KW - Microscopy, Electron, Scanning

KW - Microscopy, Fluorescence

KW - Pregnancy

U2 - 10.1098/rstb.1993.0142

DO - 10.1098/rstb.1993.0142

M3 - Journal article

C2 - 7904354

VL - 342

SP - 121

EP - 136

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0962-8436

IS - 1300

ER -