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Mitochondria, maternal inheritance, and male aging

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Mitochondria, maternal inheritance, and male aging. / Camus, M. Florencia; Clancy, David J.; Dowling, Damian K.

In: Current Biology, Vol. 22, No. 18, 2012, p. 1717-1721.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Camus, MF, Clancy, DJ & Dowling, DK 2012, 'Mitochondria, maternal inheritance, and male aging', Current Biology, vol. 22, no. 18, pp. 1717-1721. https://doi.org/10.1016/j.cub.2012.07.018

APA

Camus, M. F., Clancy, D. J., & Dowling, D. K. (2012). Mitochondria, maternal inheritance, and male aging. Current Biology, 22(18), 1717-1721. https://doi.org/10.1016/j.cub.2012.07.018

Vancouver

Author

Camus, M. Florencia ; Clancy, David J. ; Dowling, Damian K. / Mitochondria, maternal inheritance, and male aging. In: Current Biology. 2012 ; Vol. 22, No. 18. pp. 1717-1721.

Bibtex

@article{f906c4108a72467aa63d08def5da9e45,
title = "Mitochondria, maternal inheritance, and male aging",
abstract = "The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve, whereby mutations in mitochondrial DNA can only respond to selection acting directly on females [1-3]. In theory, this enables male-harming mutations to accumulate in mitochondrial genomes when these same mutations are neutral, beneficial, or only slightly deleterious in their effects on females [1-3]. Ultimately, this evolutionary process could result in the evolution of male-specific mitochondrial mutation loads; an idea previously termed Mother's Curse [2, 4-6]. Here, we present evidence that the effects of this process are broader than hitherto realized, and that it has resulted in mutation loads affecting patterns of aging in male, but not female Drosophila melanogaster. Furthermore, our results indicate that the mitochondrial mutation loads affecting male aging generally comprise numerous mutations over multiple sites. Our findings thus suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes. They implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, thus promoting the idea that a sex-specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging, commonly observed across species [7-9].",
author = "Camus, {M. Florencia} and Clancy, {David J.} and Dowling, {Damian K.}",
note = "Copyright {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",
year = "2012",
doi = "10.1016/j.cub.2012.07.018",
language = "English",
volume = "22",
pages = "1717--1721",
journal = "Current biology : CB",
issn = "0960-9822",
publisher = "CELL PRESS",
number = "18",

}

RIS

TY - JOUR

T1 - Mitochondria, maternal inheritance, and male aging

AU - Camus, M. Florencia

AU - Clancy, David J.

AU - Dowling, Damian K.

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2012

Y1 - 2012

N2 - The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve, whereby mutations in mitochondrial DNA can only respond to selection acting directly on females [1-3]. In theory, this enables male-harming mutations to accumulate in mitochondrial genomes when these same mutations are neutral, beneficial, or only slightly deleterious in their effects on females [1-3]. Ultimately, this evolutionary process could result in the evolution of male-specific mitochondrial mutation loads; an idea previously termed Mother's Curse [2, 4-6]. Here, we present evidence that the effects of this process are broader than hitherto realized, and that it has resulted in mutation loads affecting patterns of aging in male, but not female Drosophila melanogaster. Furthermore, our results indicate that the mitochondrial mutation loads affecting male aging generally comprise numerous mutations over multiple sites. Our findings thus suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes. They implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, thus promoting the idea that a sex-specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging, commonly observed across species [7-9].

AB - The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve, whereby mutations in mitochondrial DNA can only respond to selection acting directly on females [1-3]. In theory, this enables male-harming mutations to accumulate in mitochondrial genomes when these same mutations are neutral, beneficial, or only slightly deleterious in their effects on females [1-3]. Ultimately, this evolutionary process could result in the evolution of male-specific mitochondrial mutation loads; an idea previously termed Mother's Curse [2, 4-6]. Here, we present evidence that the effects of this process are broader than hitherto realized, and that it has resulted in mutation loads affecting patterns of aging in male, but not female Drosophila melanogaster. Furthermore, our results indicate that the mitochondrial mutation loads affecting male aging generally comprise numerous mutations over multiple sites. Our findings thus suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes. They implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, thus promoting the idea that a sex-specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging, commonly observed across species [7-9].

UR - http://www.scopus.com/inward/record.url?scp=84866733218&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2012.07.018

DO - 10.1016/j.cub.2012.07.018

M3 - Journal article

C2 - 22863313

VL - 22

SP - 1717

EP - 1721

JO - Current biology : CB

JF - Current biology : CB

SN - 0960-9822

IS - 18

ER -