Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Mitochondrial DNA variants in Drosophila melanogaster are expressed at the level of the organismal phenotype
AU - Aw, W. C.
AU - Correa, C. C.
AU - Clancy, D. J.
AU - Ballard, J. W. O.
PY - 2011/9
Y1 - 2011/9
N2 - A plethora of experimental studies use mtDNA as a marker of demographic processes without questioning the possibility that selection may bias their interpretations. We studied four lines of Drosophila melanogaster that have a standardized nuclear DNA but variable mtDNA. We completed the sequencing of the mitochondrial genomes (excluding the A + T rich region) and compiled the differences. We then assayed male influence on oviposition, starvation resistance, lipid proportion and physical activity. We discuss these results in terms of the known differences between the lines and conclude that naturally occurring mtDNA variants in D. melanogaster are expressed at the level of the organismal phenotype. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
AB - A plethora of experimental studies use mtDNA as a marker of demographic processes without questioning the possibility that selection may bias their interpretations. We studied four lines of Drosophila melanogaster that have a standardized nuclear DNA but variable mtDNA. We completed the sequencing of the mitochondrial genomes (excluding the A + T rich region) and compiled the differences. We then assayed male influence on oviposition, starvation resistance, lipid proportion and physical activity. We discuss these results in terms of the known differences between the lines and conclude that naturally occurring mtDNA variants in D. melanogaster are expressed at the level of the organismal phenotype. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
KW - Fecundity
KW - Starvation resistance
KW - Lipid proportion
KW - Physical activity
KW - CYTOCHROME-C-OXIDASE
KW - TRANSFER-RNA GENES
KW - LOW SPERM MOTILITY
KW - STARVATION RESISTANCE
KW - COLD RESISTANCE
KW - HUMAN MTDNA
KW - LIFE-SPAN
KW - TIGRIOPUS-CALIFORNICUS
KW - COMPARATIVE GENOMICS
KW - SECONDARY STRUCTURE
U2 - 10.1016/j.mito.2011.06.012
DO - 10.1016/j.mito.2011.06.012
M3 - Journal article
VL - 11
SP - 756
EP - 763
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
IS - 5
ER -