Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
}
TY - GEN
T1 - MLRDA
T2 - 28th International Joint Conference on Artificial Intelligence, IJCAI 2019
AU - Chu, Xu
AU - Lin, Yang
AU - Wang, Yasha
AU - Wang, Leye
AU - Wang, Jiangtao
AU - Gao, Jingyue
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Drug-drug interactions (DDIs) are a major cause of preventable hospitalizations and deaths. Recently, researchers in the AI community try to improve DDI prediction in two directions, incorporating multiple drug features to better model the pharmacodynamics and adopting multi-task learning to exploit associations among DDI types. However, these two directions are challenging to reconcile due to the sparse nature of the DDI labels which inflates the risk of overfitting of multi-task learning models when incorporating multiple drug features. In this paper, we propose a multi-task semi-supervised learning framework MLRDA for DDI prediction. MLRDA effectively exploits information that is beneficial for DDI prediction in unlabeled drug data by leveraging a novel unsupervised disentangling loss CuXCov. The CuXCov loss cooperates with the classification loss to disentangle the DDI prediction relevant part from the irrelevant part in a representation learnt by an autoencoder, which helps to ease the difficulty in mining useful information for DDI prediction in both labeled and unlabeled drug data. Moreover, MLRDA adopts a multi-task learning framework to exploit associations among DDI types. Experimental results on real-world datasets demonstrate that MLRDA significantly outperforms state-of-the-art DDI prediction methods by up to 10.3% in AUPR.
AB - Drug-drug interactions (DDIs) are a major cause of preventable hospitalizations and deaths. Recently, researchers in the AI community try to improve DDI prediction in two directions, incorporating multiple drug features to better model the pharmacodynamics and adopting multi-task learning to exploit associations among DDI types. However, these two directions are challenging to reconcile due to the sparse nature of the DDI labels which inflates the risk of overfitting of multi-task learning models when incorporating multiple drug features. In this paper, we propose a multi-task semi-supervised learning framework MLRDA for DDI prediction. MLRDA effectively exploits information that is beneficial for DDI prediction in unlabeled drug data by leveraging a novel unsupervised disentangling loss CuXCov. The CuXCov loss cooperates with the classification loss to disentangle the DDI prediction relevant part from the irrelevant part in a representation learnt by an autoencoder, which helps to ease the difficulty in mining useful information for DDI prediction in both labeled and unlabeled drug data. Moreover, MLRDA adopts a multi-task learning framework to exploit associations among DDI types. Experimental results on real-world datasets demonstrate that MLRDA significantly outperforms state-of-the-art DDI prediction methods by up to 10.3% in AUPR.
KW - Machine Learning Applications: Bio;Medicine
KW - Machine Learning: Data Mining
KW - Machine Learning: Semi-Supervised Learning
KW - Machine Learning: Deep Learning
KW - Machine Learning: Classification
U2 - 10.24963/ijcai.2019/628
DO - 10.24963/ijcai.2019/628
M3 - Conference contribution/Paper
AN - SCOPUS:85074903621
T3 - IJCAI International Joint Conference on Artificial Intelligence
SP - 4518
EP - 4524
BT - Proceedings of the 28th International Joint Conference on Artificial Intelligence, IJCAI 2019
A2 - Kraus, Sarit
PB - International Joint Conferences on Artificial Intelligence
Y2 - 10 August 2019 through 16 August 2019
ER -