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Modelling sand fly Lutzomyia longipalpis attraction to host odour: synthetic sex-aggregation pheromone dominates the response.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Modelling sand fly Lutzomyia longipalpis attraction to host odour: synthetic sex-aggregation pheromone dominates the response. / Retkute, Renata; Dilger, Erin; Hamilton, J.G.C. et al.
In: Microorganisms , Vol. 9, No. 3, 602, 15.03.2021.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Retkute, R, Dilger, E, Hamilton, JGC, Keeling, M & courtenay, O 2021, 'Modelling sand fly Lutzomyia longipalpis attraction to host odour: synthetic sex-aggregation pheromone dominates the response.', Microorganisms , vol. 9, no. 3, 602. https://doi.org/10.3390/microorganisms9030602

APA

Retkute, R., Dilger, E., Hamilton, J. G. C., Keeling, M., & courtenay, O. (2021). Modelling sand fly Lutzomyia longipalpis attraction to host odour: synthetic sex-aggregation pheromone dominates the response. Microorganisms , 9(3), Article 602. https://doi.org/10.3390/microorganisms9030602

Vancouver

Retkute R, Dilger E, Hamilton JGC, Keeling M, courtenay O. Modelling sand fly Lutzomyia longipalpis attraction to host odour: synthetic sex-aggregation pheromone dominates the response. Microorganisms . 2021 Mar 15;9(3):602. doi: 10.3390/microorganisms9030602

Author

Retkute, Renata ; Dilger, Erin ; Hamilton, J.G.C. et al. / Modelling sand fly Lutzomyia longipalpis attraction to host odour : synthetic sex-aggregation pheromone dominates the response. In: Microorganisms . 2021 ; Vol. 9, No. 3.

Bibtex

@article{57d05e890d7342f2b1b4bdd3a0da9fb9,
title = "Modelling sand fly Lutzomyia longipalpis attraction to host odour: synthetic sex-aggregation pheromone dominates the response.",
abstract = "Zoontic visceral leishmaniasis (ZVL) due to Leishmania infantum is a potentially fatal protozoan parasitic disease of humans and dogs. In the Americas, dogs are the reservoir and the sand fly, Lutzomyia longipalpis, the principal vector. A synthetic version of the male sand fly produced sex-aggregation pheromone attracts both female and male conspecifics to co-located insecticide, reducing both reservoir infection and vector abundance. However the effect of the synthetic pheromone on the vector{\textquoteright}s “choice“ of host (human, animal reservoir, or dead-end host) for blood feeding in the presence of the pheromone is less well understood. In this study, we developed a modelling framework to allow us to predict the relative attractiveness of the synthetic pheromone and potential alterations in host choice. Our analysis indicates that the synthetic pheromone can attract 53% (95% CIs: 39%–86%) of host-seeking female Lu. longipalpis and thus it out-competes competing host odours. Importantly, the results suggest that the synthetic pheromone can lure vectors away from humans and dogs, such that when co-located with insecticide, it provides protection against transmission leading to human and canine ZVL.",
keywords = "Leishmania, vector biology, host choice, disease prevention, sex-aggregation pheromone, Lutzomyia longipalpis",
author = "Renata Retkute and Erin Dilger and J.G.C. Hamilton and Matt Keeling and Orin courtenay",
year = "2021",
month = mar,
day = "15",
doi = "10.3390/microorganisms9030602",
language = "English",
volume = "9",
journal = "Microorganisms ",
issn = "2076-2607",
publisher = "MDPI - Open Access Publishing",
number = "3",

}

RIS

TY - JOUR

T1 - Modelling sand fly Lutzomyia longipalpis attraction to host odour

T2 - synthetic sex-aggregation pheromone dominates the response.

AU - Retkute, Renata

AU - Dilger, Erin

AU - Hamilton, J.G.C.

AU - Keeling, Matt

AU - courtenay, Orin

PY - 2021/3/15

Y1 - 2021/3/15

N2 - Zoontic visceral leishmaniasis (ZVL) due to Leishmania infantum is a potentially fatal protozoan parasitic disease of humans and dogs. In the Americas, dogs are the reservoir and the sand fly, Lutzomyia longipalpis, the principal vector. A synthetic version of the male sand fly produced sex-aggregation pheromone attracts both female and male conspecifics to co-located insecticide, reducing both reservoir infection and vector abundance. However the effect of the synthetic pheromone on the vector’s “choice“ of host (human, animal reservoir, or dead-end host) for blood feeding in the presence of the pheromone is less well understood. In this study, we developed a modelling framework to allow us to predict the relative attractiveness of the synthetic pheromone and potential alterations in host choice. Our analysis indicates that the synthetic pheromone can attract 53% (95% CIs: 39%–86%) of host-seeking female Lu. longipalpis and thus it out-competes competing host odours. Importantly, the results suggest that the synthetic pheromone can lure vectors away from humans and dogs, such that when co-located with insecticide, it provides protection against transmission leading to human and canine ZVL.

AB - Zoontic visceral leishmaniasis (ZVL) due to Leishmania infantum is a potentially fatal protozoan parasitic disease of humans and dogs. In the Americas, dogs are the reservoir and the sand fly, Lutzomyia longipalpis, the principal vector. A synthetic version of the male sand fly produced sex-aggregation pheromone attracts both female and male conspecifics to co-located insecticide, reducing both reservoir infection and vector abundance. However the effect of the synthetic pheromone on the vector’s “choice“ of host (human, animal reservoir, or dead-end host) for blood feeding in the presence of the pheromone is less well understood. In this study, we developed a modelling framework to allow us to predict the relative attractiveness of the synthetic pheromone and potential alterations in host choice. Our analysis indicates that the synthetic pheromone can attract 53% (95% CIs: 39%–86%) of host-seeking female Lu. longipalpis and thus it out-competes competing host odours. Importantly, the results suggest that the synthetic pheromone can lure vectors away from humans and dogs, such that when co-located with insecticide, it provides protection against transmission leading to human and canine ZVL.

KW - Leishmania

KW - vector biology

KW - host choice

KW - disease prevention

KW - sex-aggregation pheromone

KW - Lutzomyia longipalpis

U2 - 10.3390/microorganisms9030602

DO - 10.3390/microorganisms9030602

M3 - Journal article

VL - 9

JO - Microorganisms

JF - Microorganisms

SN - 2076-2607

IS - 3

M1 - 602

ER -