Home > Research > Publications & Outputs > Modelling the interaction of haemodynamics and ...

Research

Links

Text available via DOI:

Keywords

View graph of relations

Modelling the interaction of haemodynamics and the artery wall: current status and future prospects

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Modelling the interaction of haemodynamics and the artery wall: current status and future prospects. / Lawford, P. V.; Ventikos, Y.; Khir, A. W. et al.
In: Biomedicine and Pharmacotherapy, Vol. 62, No. 8, 10.2008, p. 530-535.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lawford, PV, Ventikos, Y, Khir, AW, Atherton, M, Evans, D, Hose, DR, Care, CM, Watton, PN, Halliday, I, Walker, DC, Hollis, AP & Collins, MW 2008, 'Modelling the interaction of haemodynamics and the artery wall: current status and future prospects', Biomedicine and Pharmacotherapy, vol. 62, no. 8, pp. 530-535. https://doi.org/10.1016/j.biopha.2008.07.054

APA

Lawford, P. V., Ventikos, Y., Khir, A. W., Atherton, M., Evans, D., Hose, D. R., Care, C. M., Watton, P. N., Halliday, I., Walker, D. C., Hollis, A. P., & Collins, M. W. (2008). Modelling the interaction of haemodynamics and the artery wall: current status and future prospects. Biomedicine and Pharmacotherapy, 62(8), 530-535. https://doi.org/10.1016/j.biopha.2008.07.054

Vancouver

Lawford PV, Ventikos Y, Khir AW, Atherton M, Evans D, Hose DR et al. Modelling the interaction of haemodynamics and the artery wall: current status and future prospects. Biomedicine and Pharmacotherapy. 2008 Oct;62(8):530-535. doi: 10.1016/j.biopha.2008.07.054

Author

Lawford, P. V. ; Ventikos, Y. ; Khir, A. W. et al. / Modelling the interaction of haemodynamics and the artery wall : current status and future prospects. In: Biomedicine and Pharmacotherapy. 2008 ; Vol. 62, No. 8. pp. 530-535.

Bibtex

@article{761a4b4aaaae470383665aa39555bca8,
title = "Modelling the interaction of haemodynamics and the artery wall: current status and future prospects",
abstract = "Clinical research has historically focused on the two main strategies of in vivo and in vitro experimentation. The concept of applying scientific theory to direct clinical applications is relatively recent. In this paper we focus on the interaction of wall shear stress with the endothelium and discuss how {\textquoteleft}state of the art{\textquoteright} computer modelling techniques can provide valuable data to aid understanding. Such data may be used to inform experiment and further, may help identify the key features of this complex system. Current emphasis is on coupling haemodynamics with models of biological phenomena to test hypotheses or predict the likely outcome of a disease or an intervention. New technologies to enable the integration of models of different types, levels of complexity and scales, are being developed. As will be discussed, the ultimate goal is the translation of this technology to the clinical arena.",
keywords = "Haemodynamics, Endothelium, Shear stress, Atherosclerosis",
author = "Lawford, {P. V.} and Y. Ventikos and Khir, {A. W.} and M. Atherton and David Evans and Hose, {D. R.} and Care, {C. M.} and Watton, {P. N.} and I. Halliday and Walker, {D. C.} and Hollis, {A. P.} and Collins, {M. W.}",
year = "2008",
month = oct,
doi = "10.1016/j.biopha.2008.07.054",
language = "English",
volume = "62",
pages = "530--535",
journal = "Biomedicine and Pharmacotherapy",
publisher = "Elsevier Masson",
number = "8",

}

RIS

TY - JOUR

T1 - Modelling the interaction of haemodynamics and the artery wall

T2 - current status and future prospects

AU - Lawford, P. V.

AU - Ventikos, Y.

AU - Khir, A. W.

AU - Atherton, M.

AU - Evans, David

AU - Hose, D. R.

AU - Care, C. M.

AU - Watton, P. N.

AU - Halliday, I.

AU - Walker, D. C.

AU - Hollis, A. P.

AU - Collins, M. W.

PY - 2008/10

Y1 - 2008/10

N2 - Clinical research has historically focused on the two main strategies of in vivo and in vitro experimentation. The concept of applying scientific theory to direct clinical applications is relatively recent. In this paper we focus on the interaction of wall shear stress with the endothelium and discuss how ‘state of the art’ computer modelling techniques can provide valuable data to aid understanding. Such data may be used to inform experiment and further, may help identify the key features of this complex system. Current emphasis is on coupling haemodynamics with models of biological phenomena to test hypotheses or predict the likely outcome of a disease or an intervention. New technologies to enable the integration of models of different types, levels of complexity and scales, are being developed. As will be discussed, the ultimate goal is the translation of this technology to the clinical arena.

AB - Clinical research has historically focused on the two main strategies of in vivo and in vitro experimentation. The concept of applying scientific theory to direct clinical applications is relatively recent. In this paper we focus on the interaction of wall shear stress with the endothelium and discuss how ‘state of the art’ computer modelling techniques can provide valuable data to aid understanding. Such data may be used to inform experiment and further, may help identify the key features of this complex system. Current emphasis is on coupling haemodynamics with models of biological phenomena to test hypotheses or predict the likely outcome of a disease or an intervention. New technologies to enable the integration of models of different types, levels of complexity and scales, are being developed. As will be discussed, the ultimate goal is the translation of this technology to the clinical arena.

KW - Haemodynamics

KW - Endothelium

KW - Shear stress

KW - Atherosclerosis

U2 - 10.1016/j.biopha.2008.07.054

DO - 10.1016/j.biopha.2008.07.054

M3 - Journal article

VL - 62

SP - 530

EP - 535

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

IS - 8

ER -