Home > Research > Publications & Outputs > Molecular basis for dimethylsulfoxide (DMSO) ac...

Research

Links

Text available via DOI:

Keywords

View graph of relations

Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes. / Notman, Rebecca; Noro, Massimo; O'Malley, Brendan et al.
In: Journal of the American Chemical Society, Vol. 128, No. 43, 01.11.2006, p. 13982-13983.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Notman, R, Noro, M, O'Malley, B & Anwar, J 2006, 'Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes', Journal of the American Chemical Society, vol. 128, no. 43, pp. 13982-13983. https://doi.org/10.1021/ja063363t

APA

Notman, R., Noro, M., O'Malley, B., & Anwar, J. (2006). Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes. Journal of the American Chemical Society, 128(43), 13982-13983. https://doi.org/10.1021/ja063363t

Vancouver

Notman R, Noro M, O'Malley B, Anwar J. Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes. Journal of the American Chemical Society. 2006 Nov 1;128(43):13982-13983. doi: 10.1021/ja063363t

Author

Notman, Rebecca ; Noro, Massimo ; O'Malley, Brendan et al. / Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes. In: Journal of the American Chemical Society. 2006 ; Vol. 128, No. 43. pp. 13982-13983.

Bibtex

@article{9506253aed7e43bea14efcfb9a0cd3af,
title = "Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes",
abstract = "Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation.",
keywords = "PHOSPHOLIPID-BILAYERS, SYSTEM, DIMETHYL-SULFOXIDE, PORE FORMATION, SIMULATION",
author = "Rebecca Notman and Massimo Noro and Brendan O'Malley and Jamshed Anwar",
year = "2006",
month = nov,
day = "1",
doi = "10.1021/ja063363t",
language = "English",
volume = "128",
pages = "13982--13983",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "AMER CHEMICAL SOC",
number = "43",

}

RIS

TY - JOUR

T1 - Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes

AU - Notman, Rebecca

AU - Noro, Massimo

AU - O'Malley, Brendan

AU - Anwar, Jamshed

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation.

AB - Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation.

KW - PHOSPHOLIPID-BILAYERS

KW - SYSTEM

KW - DIMETHYL-SULFOXIDE

KW - PORE FORMATION

KW - SIMULATION

U2 - 10.1021/ja063363t

DO - 10.1021/ja063363t

M3 - Journal article

VL - 128

SP - 13982

EP - 13983

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 43

ER -