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Moonlighting enzymes in parasitic protozoa.

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Moonlighting enzymes in parasitic protozoa. / Collingridge, Peter W.; Brown, Robert W. B.; Ginger, Michael L.
In: Parasitology, Vol. 137, No. 9, 08.2010, p. 1467-1475.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Collingridge, PW, Brown, RWB & Ginger, ML 2010, 'Moonlighting enzymes in parasitic protozoa.', Parasitology, vol. 137, no. 9, pp. 1467-1475. https://doi.org/10.1017/S0031182010000259

APA

Collingridge, P. W., Brown, R. W. B., & Ginger, M. L. (2010). Moonlighting enzymes in parasitic protozoa. Parasitology, 137(9), 1467-1475. https://doi.org/10.1017/S0031182010000259

Vancouver

Collingridge PW, Brown RWB, Ginger ML. Moonlighting enzymes in parasitic protozoa. Parasitology. 2010 Aug;137(9):1467-1475. doi: 10.1017/S0031182010000259

Author

Collingridge, Peter W. ; Brown, Robert W. B. ; Ginger, Michael L. / Moonlighting enzymes in parasitic protozoa. In: Parasitology. 2010 ; Vol. 137, No. 9. pp. 1467-1475.

Bibtex

@article{a3cd791ff5304f7b8474903c81d80c79,
title = "Moonlighting enzymes in parasitic protozoa.",
abstract = "Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.",
author = "Collingridge, {Peter W.} and Brown, {Robert W. B.} and Ginger, {Michael L.}",
note = "http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 137 (9), pp 1467-1475 2010, {\textcopyright} 2010 Cambridge University Press.",
year = "2010",
month = aug,
doi = "10.1017/S0031182010000259",
language = "English",
volume = "137",
pages = "1467--1475",
journal = "Parasitology",
issn = "0031-1820",
publisher = "Cambridge University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Moonlighting enzymes in parasitic protozoa.

AU - Collingridge, Peter W.

AU - Brown, Robert W. B.

AU - Ginger, Michael L.

N1 - http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 137 (9), pp 1467-1475 2010, © 2010 Cambridge University Press.

PY - 2010/8

Y1 - 2010/8

N2 - Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.

AB - Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.

U2 - 10.1017/S0031182010000259

DO - 10.1017/S0031182010000259

M3 - Journal article

VL - 137

SP - 1467

EP - 1475

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 9

ER -