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Morphogenesis of Human Placental Chorionic Villi: Cytoskeletal, Syncytioskeletal and Extracellular Matrix Proteins

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<mark>Journal publication date</mark>14/07/1981
<mark>Journal</mark>Proceedings of the Royal Society B: Biological Sciences
Issue number1188
Volume212
Number of pages12
Pages (from-to)305-316
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Immunocytochemical and ultrastructural methods were used to investigate the distribution of a family of structural proteins in the human placenta near term. These reveal the distribution of cytoskeletal and `syncytioskeletal' components that may account for some of the more obvious micromorphological features of placental structure. In the syncytiotrophoblast a potentially supporting structure `the syncytioskeletal layer' is described. It is an apparently continuous and complex polymeric network covering the villous tree, a surface of the order of 10 m$^{2}$ in area in the full term placenta (Aherne & Dunnill 1966). It is suggested that this layer plays a part in morphogenesis of the villous tree.