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Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers. / Mendes, A.C.; Moreno, J.S.; Hanif, M. et al.
In: International Journal of Molecular Sciences, Vol. 19, No. 8, 2266, 02.08.2018.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Mendes, AC, Moreno, JS, Hanif, M, Douglas, TEL, Chen, M & Chronakis, IS 2018, 'Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers', International Journal of Molecular Sciences, vol. 19, no. 8, 2266. https://doi.org/10.3390/ijms19082266

APA

Mendes, A. C., Moreno, J. S., Hanif, M., Douglas, T. E. L., Chen, M., & Chronakis, I. S. (2018). Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers. International Journal of Molecular Sciences, 19(8), Article 2266. https://doi.org/10.3390/ijms19082266

Vancouver

Mendes AC, Moreno JS, Hanif M, Douglas TEL, Chen M, Chronakis IS. Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers. International Journal of Molecular Sciences. 2018 Aug 2;19(8):2266. doi: 10.3390/ijms19082266

Author

Mendes, A.C. ; Moreno, J.S. ; Hanif, M. et al. / Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 8.

Bibtex

@article{fc606b7d5dd74d4993a099162a0f3070,
title = "Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers",
abstract = "This study aimed to develop hybrid electrospun chitosan–phospholipid nanofibers and investigate the effect of phospholipid (P) content and chitosans (Ch) molecular weights (Mw) and degree of acetylation (DA), on the morphological, mechanical and mucoadhesive properties of the nanofibers. Electrospun Ch/P nanofibers exhibited a smooth and uniform surface with average diameters ranging from 300 to 1000 nm, as observed by scanning electron microscopy (SEM). The average diameter of the nanofibers was observed to increase with the increase of the Mw and degree of deacetylation of Ch, and phospholipid content. The elastic and adhesive properties of the nanofibers were determined by atomic force microscopy, and displayed higher values for higher Mw and lower DA Ch used. The elastic modulus of electrospun Ch/P hybrid fibers determined for the different conditions tested was found to be in the range of 500 and 1400 MPa. Furthermore, electrospun Ch/P nanofibers displayed mucoadhesive properties expressed by the work of adhesion calculated after the compression of the nanofibers against a section of pig small intestine. Our results showed that the increase in phospholipid content and DA of Ch decrease the work of adhesion, while the increase of Mw resulted in slightly higher work of adhesion of the nanofibers. {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
keywords = "Chitosan, Elastic modulus, Electrospun fibers, Mucoadhesion, Phospholipids, chitosan, nanofiber, phospholipid, adhesive agent, acetylation, Article, atomic force microscopy, controlled study, deacetylation, electrospinning, molecular weight, mucoadhesion, particle size, photon correlation spectroscopy, pig, scanning electron microscopy, small intestine, surface property, Young modulus, zeta potential, animal, chemistry, intestine mucosa, materials testing, metabolism, ultrastructure, Adhesives, Animals, Elastic Modulus, Intestinal Mucosa, Intestine, Small, Materials Testing, Nanofibers, Swine",
author = "A.C. Mendes and J.S. Moreno and M. Hanif and Douglas, {Timothy E. L.} and M. Chen and I.S. Chronakis",
year = "2018",
month = aug,
day = "2",
doi = "10.3390/ijms19082266",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - Morphological, mechanical and mucoadhesive properties of electrospun chitosan/phospholipid hybrid nanofibers

AU - Mendes, A.C.

AU - Moreno, J.S.

AU - Hanif, M.

AU - Douglas, Timothy E. L.

AU - Chen, M.

AU - Chronakis, I.S.

PY - 2018/8/2

Y1 - 2018/8/2

N2 - This study aimed to develop hybrid electrospun chitosan–phospholipid nanofibers and investigate the effect of phospholipid (P) content and chitosans (Ch) molecular weights (Mw) and degree of acetylation (DA), on the morphological, mechanical and mucoadhesive properties of the nanofibers. Electrospun Ch/P nanofibers exhibited a smooth and uniform surface with average diameters ranging from 300 to 1000 nm, as observed by scanning electron microscopy (SEM). The average diameter of the nanofibers was observed to increase with the increase of the Mw and degree of deacetylation of Ch, and phospholipid content. The elastic and adhesive properties of the nanofibers were determined by atomic force microscopy, and displayed higher values for higher Mw and lower DA Ch used. The elastic modulus of electrospun Ch/P hybrid fibers determined for the different conditions tested was found to be in the range of 500 and 1400 MPa. Furthermore, electrospun Ch/P nanofibers displayed mucoadhesive properties expressed by the work of adhesion calculated after the compression of the nanofibers against a section of pig small intestine. Our results showed that the increase in phospholipid content and DA of Ch decrease the work of adhesion, while the increase of Mw resulted in slightly higher work of adhesion of the nanofibers. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

AB - This study aimed to develop hybrid electrospun chitosan–phospholipid nanofibers and investigate the effect of phospholipid (P) content and chitosans (Ch) molecular weights (Mw) and degree of acetylation (DA), on the morphological, mechanical and mucoadhesive properties of the nanofibers. Electrospun Ch/P nanofibers exhibited a smooth and uniform surface with average diameters ranging from 300 to 1000 nm, as observed by scanning electron microscopy (SEM). The average diameter of the nanofibers was observed to increase with the increase of the Mw and degree of deacetylation of Ch, and phospholipid content. The elastic and adhesive properties of the nanofibers were determined by atomic force microscopy, and displayed higher values for higher Mw and lower DA Ch used. The elastic modulus of electrospun Ch/P hybrid fibers determined for the different conditions tested was found to be in the range of 500 and 1400 MPa. Furthermore, electrospun Ch/P nanofibers displayed mucoadhesive properties expressed by the work of adhesion calculated after the compression of the nanofibers against a section of pig small intestine. Our results showed that the increase in phospholipid content and DA of Ch decrease the work of adhesion, while the increase of Mw resulted in slightly higher work of adhesion of the nanofibers. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

KW - Chitosan

KW - Elastic modulus

KW - Electrospun fibers

KW - Mucoadhesion

KW - Phospholipids

KW - chitosan

KW - nanofiber

KW - phospholipid

KW - adhesive agent

KW - acetylation

KW - Article

KW - atomic force microscopy

KW - controlled study

KW - deacetylation

KW - electrospinning

KW - molecular weight

KW - mucoadhesion

KW - particle size

KW - photon correlation spectroscopy

KW - pig

KW - scanning electron microscopy

KW - small intestine

KW - surface property

KW - Young modulus

KW - zeta potential

KW - animal

KW - chemistry

KW - intestine mucosa

KW - materials testing

KW - metabolism

KW - ultrastructure

KW - Adhesives

KW - Animals

KW - Elastic Modulus

KW - Intestinal Mucosa

KW - Intestine, Small

KW - Materials Testing

KW - Nanofibers

KW - Swine

U2 - 10.3390/ijms19082266

DO - 10.3390/ijms19082266

M3 - Journal article

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 8

M1 - 2266

ER -