Home > Research > Publications & Outputs > NADPH oxidase (CYBA) and FcgammaR polymorphisms...

Research

Links

Text available via DOI:

Keywords

View graph of relations

NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study. / Nibali, L.; Parkar, M.; Brett, P. et al.
In: Journal of Clinical Periodontology, Vol. 33, No. 8, 08.2006, p. 529-539.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Nibali, L, Parkar, M, Brett, P, Knight, J, Tonetti, MS & Griffiths, GS 2006, 'NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study', Journal of Clinical Periodontology, vol. 33, no. 8, pp. 529-539. https://doi.org/10.1111/j.1600-051X.2006.00952.x

APA

Nibali, L., Parkar, M., Brett, P., Knight, J., Tonetti, M. S., & Griffiths, G. S. (2006). NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study. Journal of Clinical Periodontology, 33(8), 529-539. https://doi.org/10.1111/j.1600-051X.2006.00952.x

Vancouver

Nibali L, Parkar M, Brett P, Knight J, Tonetti MS, Griffiths GS. NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study. Journal of Clinical Periodontology. 2006 Aug;33(8):529-539. Epub 2006 Jul 17. doi: 10.1111/j.1600-051X.2006.00952.x

Author

Nibali, L. ; Parkar, M. ; Brett, P. et al. / NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis : a case-control association study. In: Journal of Clinical Periodontology. 2006 ; Vol. 33, No. 8. pp. 529-539.

Bibtex

@article{7520fca693994a73a5ebfec1e5915e13,
title = "NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study",
abstract = "INTRODUCTION: Neutrophils (PMN) in aggressive periodontitis (AgP) patients have been reported to be hyperactive especially with regards to superoxide production. Polymorphisms in genes influencing PMN function have been proposed as candidate risk factors for AgP. The aim of this study was to test the association of specific gene polymorphisms affecting PMN functions with AgP.MATERIALS AND METHODS: Two hundred and twenty-four patients with confirmed diagnosis of AgP and 231 subjects with healthy periodontium took part in the study. A blood sample was collected from subjects and genotypes for p22phox (CYBA) NADPH oxidase, FP, Fcalpha and Fcgamma receptors were analysed in a blind fashion.RESULTS: The C242T p22phox NADPH oxidase T allele was significantly associated with AgP in a multiple logistic regression model adjusting for confounders, and this was observed for all subjects [p = 0.002, odds ratio (OR) = 1.87, 95% confidence interval (CI) = 1.27-2.83] and Caucasians (p = 0.009, OR=2.07, 95% CI = 1.20-3.59). Concomitant presence of C242T p22phox NADPH oxidase T allele and FcgammaRIIIb NA1 homozygosity was associated with the generalized AgP phenotype in Caucasians (p = 0.001, OR = 30.35, 95% CI = 3.81-241.97).CONCLUSIONS: C242T p22phox NADPH oxidase and FcgammaR polymorphisms may predispose to AgP through a modulation of neutrophil superoxide production.",
keywords = "Adult, Alleles, Antigens, CD, Case-Control Studies, Female, GPI-Linked Proteins, Haplotypes, Humans, Immunoglobulin A, Male, NADPH Oxidase, Neutrophil Activation, Periodontitis, Polymorphism, Genetic, Receptors, Fc, Receptors, Formyl Peptide, Receptors, IgG, Risk Factors, Sex Factors, Single-Blind Method, Smoking",
author = "L. Nibali and M. Parkar and P. Brett and Jo Knight and Tonetti, {M. S.} and Griffiths, {G. S.}",
year = "2006",
month = aug,
doi = "10.1111/j.1600-051X.2006.00952.x",
language = "English",
volume = "33",
pages = "529--539",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Blackwell Munksgaard",
number = "8",

}

RIS

TY - JOUR

T1 - NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis

T2 - a case-control association study

AU - Nibali, L.

AU - Parkar, M.

AU - Brett, P.

AU - Knight, Jo

AU - Tonetti, M. S.

AU - Griffiths, G. S.

PY - 2006/8

Y1 - 2006/8

N2 - INTRODUCTION: Neutrophils (PMN) in aggressive periodontitis (AgP) patients have been reported to be hyperactive especially with regards to superoxide production. Polymorphisms in genes influencing PMN function have been proposed as candidate risk factors for AgP. The aim of this study was to test the association of specific gene polymorphisms affecting PMN functions with AgP.MATERIALS AND METHODS: Two hundred and twenty-four patients with confirmed diagnosis of AgP and 231 subjects with healthy periodontium took part in the study. A blood sample was collected from subjects and genotypes for p22phox (CYBA) NADPH oxidase, FP, Fcalpha and Fcgamma receptors were analysed in a blind fashion.RESULTS: The C242T p22phox NADPH oxidase T allele was significantly associated with AgP in a multiple logistic regression model adjusting for confounders, and this was observed for all subjects [p = 0.002, odds ratio (OR) = 1.87, 95% confidence interval (CI) = 1.27-2.83] and Caucasians (p = 0.009, OR=2.07, 95% CI = 1.20-3.59). Concomitant presence of C242T p22phox NADPH oxidase T allele and FcgammaRIIIb NA1 homozygosity was associated with the generalized AgP phenotype in Caucasians (p = 0.001, OR = 30.35, 95% CI = 3.81-241.97).CONCLUSIONS: C242T p22phox NADPH oxidase and FcgammaR polymorphisms may predispose to AgP through a modulation of neutrophil superoxide production.

AB - INTRODUCTION: Neutrophils (PMN) in aggressive periodontitis (AgP) patients have been reported to be hyperactive especially with regards to superoxide production. Polymorphisms in genes influencing PMN function have been proposed as candidate risk factors for AgP. The aim of this study was to test the association of specific gene polymorphisms affecting PMN functions with AgP.MATERIALS AND METHODS: Two hundred and twenty-four patients with confirmed diagnosis of AgP and 231 subjects with healthy periodontium took part in the study. A blood sample was collected from subjects and genotypes for p22phox (CYBA) NADPH oxidase, FP, Fcalpha and Fcgamma receptors were analysed in a blind fashion.RESULTS: The C242T p22phox NADPH oxidase T allele was significantly associated with AgP in a multiple logistic regression model adjusting for confounders, and this was observed for all subjects [p = 0.002, odds ratio (OR) = 1.87, 95% confidence interval (CI) = 1.27-2.83] and Caucasians (p = 0.009, OR=2.07, 95% CI = 1.20-3.59). Concomitant presence of C242T p22phox NADPH oxidase T allele and FcgammaRIIIb NA1 homozygosity was associated with the generalized AgP phenotype in Caucasians (p = 0.001, OR = 30.35, 95% CI = 3.81-241.97).CONCLUSIONS: C242T p22phox NADPH oxidase and FcgammaR polymorphisms may predispose to AgP through a modulation of neutrophil superoxide production.

KW - Adult

KW - Alleles

KW - Antigens, CD

KW - Case-Control Studies

KW - Female

KW - GPI-Linked Proteins

KW - Haplotypes

KW - Humans

KW - Immunoglobulin A

KW - Male

KW - NADPH Oxidase

KW - Neutrophil Activation

KW - Periodontitis

KW - Polymorphism, Genetic

KW - Receptors, Fc

KW - Receptors, Formyl Peptide

KW - Receptors, IgG

KW - Risk Factors

KW - Sex Factors

KW - Single-Blind Method

KW - Smoking

U2 - 10.1111/j.1600-051X.2006.00952.x

DO - 10.1111/j.1600-051X.2006.00952.x

M3 - Journal article

C2 - 16899095

VL - 33

SP - 529

EP - 539

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 8

ER -