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Nesfatin-1, a unique regulatory neuropeptide of the brain

Research output: Contribution to Journal/Magazine › Literature review › peer-review

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Nesfatin-1, a unique regulatory neuropeptide of the brain. / Palasz, Artur; Krzystanek, Marek; Worthington, John et al.
In: Neuropeptides, Vol. 46, No. 3, 06.2012, p. 105-112.

Research output: Contribution to Journal/Magazine › Literature review › peer-review

Harvard

Palasz, A, Krzystanek, M, Worthington, J, Czajkowska, B, Kostro, K, Wiaderkiewicz, R & Bajor, G 2012, 'Nesfatin-1, a unique regulatory neuropeptide of the brain', Neuropeptides, vol. 46, no. 3, pp. 105-112. https://doi.org/10.1016/j.npep.2011.12.002

APA

Palasz, A., Krzystanek, M., Worthington, J., Czajkowska, B., Kostro, K., Wiaderkiewicz, R., & Bajor, G. (2012). Nesfatin-1, a unique regulatory neuropeptide of the brain. Neuropeptides, 46(3), 105-112. https://doi.org/10.1016/j.npep.2011.12.002

Vancouver

Palasz A, Krzystanek M, Worthington J, Czajkowska B, Kostro K, Wiaderkiewicz R et al. Nesfatin-1, a unique regulatory neuropeptide of the brain. Neuropeptides. 2012 Jun;46(3):105-112. Epub 2012 Jan 5. doi: 10.1016/j.npep.2011.12.002

Author

Palasz, Artur ; Krzystanek, Marek ; Worthington, John et al. / Nesfatin-1, a unique regulatory neuropeptide of the brain. In: Neuropeptides. 2012 ; Vol. 46, No. 3. pp. 105-112.

Bibtex

@article{184d971aef314d0caddcf2c920839d36,
title = "Nesfatin-1, a unique regulatory neuropeptide of the brain",
abstract = "Nesfatin-1, a newly discovered NUCB2-derived satiety neuropeptide is expressed in several neurons of forebrain, hindbrain, brainstem and spinal cord. This novel anorexigenic substance seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis. Nesfatin-1 immunoreactive cells are detectable in arcuate (ARC), paraventricular (PVN) and supraoptic nuclei (SON), where the peptide is colocalized with POMC/CART, NPY, oxytocin and vasopressin. The nesfatin-1 molecule interacts with a G-protein coupled receptor and its cytophysiological effect depends on inhibitory hyperpolarization of NPY/AgRP neurons in ARC and melanocortin signaling in PVN. Administration of nesfatin-1 significantly inhibits consumatory behavior and decreases weight gain in experimental animals. These recent findings suggest the evidence for nesfatin-1 involvement in other important brain functions such as reproduction, sleep, cognition and anxiety- or stress-related responses. The neuroprotective and antiapoptotic properties of nesfatin-1 were also reported. From the clinical viewpoint it should be noteworthy, that the serum concentration of nesfatin-1 may be a sensitive marker of epileptic seizures. However, the details of nesfatin-1 physiology ought to be clarified, and it may be considered suitable in the future, as a potential drug in the pharmacotherapy of obesity, especially in patients treated with antipsychotics and antidepressants. On the other hand, some putative nesfatin-1 antagonists may improve eating disorders. (C) 2011 Elsevier Ltd. All rights reserved.",
keywords = "Nesfatin-1, NUCB2, Neuropeptides, Hypothalamus, Anorexia, PITUITARY-ADRENAL AXIS, PARAVENTRICULAR NUCLEUS, SUPRAOPTIC NUCLEI, ANOREXIA-NERVOSA, ARCUATE NUCLEUS, RAT-BRAIN, C-FOS, NEURONS, HYPOTHALAMUS, RECEPTOR",
author = "Artur Palasz and Marek Krzystanek and John Worthington and Beata Czajkowska and Karol Kostro and Ryszard Wiaderkiewicz and Grzegorz Bajor",
year = "2012",
month = jun,
doi = "10.1016/j.npep.2011.12.002",
language = "English",
volume = "46",
pages = "105--112",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",
number = "3",

}

RIS

TY - JOUR

T1 - Nesfatin-1, a unique regulatory neuropeptide of the brain

AU - Palasz, Artur

AU - Krzystanek, Marek

AU - Worthington, John

AU - Czajkowska, Beata

AU - Kostro, Karol

AU - Wiaderkiewicz, Ryszard

AU - Bajor, Grzegorz

PY - 2012/6

Y1 - 2012/6

N2 - Nesfatin-1, a newly discovered NUCB2-derived satiety neuropeptide is expressed in several neurons of forebrain, hindbrain, brainstem and spinal cord. This novel anorexigenic substance seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis. Nesfatin-1 immunoreactive cells are detectable in arcuate (ARC), paraventricular (PVN) and supraoptic nuclei (SON), where the peptide is colocalized with POMC/CART, NPY, oxytocin and vasopressin. The nesfatin-1 molecule interacts with a G-protein coupled receptor and its cytophysiological effect depends on inhibitory hyperpolarization of NPY/AgRP neurons in ARC and melanocortin signaling in PVN. Administration of nesfatin-1 significantly inhibits consumatory behavior and decreases weight gain in experimental animals. These recent findings suggest the evidence for nesfatin-1 involvement in other important brain functions such as reproduction, sleep, cognition and anxiety- or stress-related responses. The neuroprotective and antiapoptotic properties of nesfatin-1 were also reported. From the clinical viewpoint it should be noteworthy, that the serum concentration of nesfatin-1 may be a sensitive marker of epileptic seizures. However, the details of nesfatin-1 physiology ought to be clarified, and it may be considered suitable in the future, as a potential drug in the pharmacotherapy of obesity, especially in patients treated with antipsychotics and antidepressants. On the other hand, some putative nesfatin-1 antagonists may improve eating disorders. (C) 2011 Elsevier Ltd. All rights reserved.

AB - Nesfatin-1, a newly discovered NUCB2-derived satiety neuropeptide is expressed in several neurons of forebrain, hindbrain, brainstem and spinal cord. This novel anorexigenic substance seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis. Nesfatin-1 immunoreactive cells are detectable in arcuate (ARC), paraventricular (PVN) and supraoptic nuclei (SON), where the peptide is colocalized with POMC/CART, NPY, oxytocin and vasopressin. The nesfatin-1 molecule interacts with a G-protein coupled receptor and its cytophysiological effect depends on inhibitory hyperpolarization of NPY/AgRP neurons in ARC and melanocortin signaling in PVN. Administration of nesfatin-1 significantly inhibits consumatory behavior and decreases weight gain in experimental animals. These recent findings suggest the evidence for nesfatin-1 involvement in other important brain functions such as reproduction, sleep, cognition and anxiety- or stress-related responses. The neuroprotective and antiapoptotic properties of nesfatin-1 were also reported. From the clinical viewpoint it should be noteworthy, that the serum concentration of nesfatin-1 may be a sensitive marker of epileptic seizures. However, the details of nesfatin-1 physiology ought to be clarified, and it may be considered suitable in the future, as a potential drug in the pharmacotherapy of obesity, especially in patients treated with antipsychotics and antidepressants. On the other hand, some putative nesfatin-1 antagonists may improve eating disorders. (C) 2011 Elsevier Ltd. All rights reserved.

KW - Nesfatin-1

KW - NUCB2

KW - Neuropeptides

KW - Hypothalamus

KW - Anorexia

KW - PITUITARY-ADRENAL AXIS

KW - PARAVENTRICULAR NUCLEUS

KW - SUPRAOPTIC NUCLEI

KW - ANOREXIA-NERVOSA

KW - ARCUATE NUCLEUS

KW - RAT-BRAIN

KW - C-FOS

KW - NEURONS

KW - HYPOTHALAMUS

KW - RECEPTOR

U2 - 10.1016/j.npep.2011.12.002

DO - 10.1016/j.npep.2011.12.002

M3 - Literature review

VL - 46

SP - 105

EP - 112

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

IS - 3

ER -