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Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem

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Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem. / Pałasz, A.; Ozimirska, K.; Suszka-Świtek, A. et al.
In: Neuropeptides, Vol. 109, 102484, 31.01.2025.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Pałasz, A, Ozimirska, K, Suszka-Świtek, A, Bogus, K, Błaszczyk, I, Sharma, V, Pukowiec, M, Worthington, JJ, Młynarczuk-Biały, I & Lipiec-Borowicz, A 2025, 'Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem', Neuropeptides, vol. 109, 102484. https://doi.org/10.1016/j.npep.2024.102484

APA

Pałasz, A., Ozimirska, K., Suszka-Świtek, A., Bogus, K., Błaszczyk, I., Sharma, V., Pukowiec, M., Worthington, J. J., Młynarczuk-Biały, I., & Lipiec-Borowicz, A. (2025). Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem. Neuropeptides, 109, Article 102484. https://doi.org/10.1016/j.npep.2024.102484

Vancouver

Pałasz A, Ozimirska K, Suszka-Świtek A, Bogus K, Błaszczyk I, Sharma V et al. Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem. Neuropeptides. 2025 Jan 31;109:102484. Epub 2024 Nov 13. doi: 10.1016/j.npep.2024.102484

Author

Pałasz, A. ; Ozimirska, K. ; Suszka-Świtek, A. et al. / Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem. In: Neuropeptides. 2025 ; Vol. 109.

Bibtex

@article{13f3bc37124b49169b1955f905edbf43,
title = "Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem",
abstract = "Neuropeptides are involved in numerous brain activities being able to control a wide spectrum of physiological functions. In recent years, a number of novel pleiotropic regulatory peptides have been discovered in animal brain structures. The purpose of this descriptive neurochemical investigation was to detect the possible expression of the novel multifunctional neuropeptides spexin (SPX) and nesfatin-1 within the human brainstem. Using immunohistochemical and fluorescence techniques, neuroanatomical analysis of the SPX and nesfatin-1 expression and distribution was performed in selected sections of the human midbrain and medulla oblongata. The presence of SPX-positive neurons in the human brainstem was revealed for the first time and previous reports on the expression of nesfatin-1 were additionally confirmed. The research results suggest that SPX and nesfatin-1 are new regulatory neuropeptides of the human brainstem potentially involved in the regulation of key autonomic activities of this brain region.",
author = "A. Pa{\l}asz and K. Ozimirska and A. Suszka-{\'S}witek and K. Bogus and I. B{\l}aszczyk and V. Sharma and M. Pukowiec and J.J. Worthington and I. M{\l}ynarczuk-Bia{\l}y and A. Lipiec-Borowicz",
year = "2025",
month = jan,
day = "31",
doi = "10.1016/j.npep.2024.102484",
language = "English",
volume = "109",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem

AU - Pałasz, A.

AU - Ozimirska, K.

AU - Suszka-Świtek, A.

AU - Bogus, K.

AU - Błaszczyk, I.

AU - Sharma, V.

AU - Pukowiec, M.

AU - Worthington, J.J.

AU - Młynarczuk-Biały, I.

AU - Lipiec-Borowicz, A.

PY - 2025/1/31

Y1 - 2025/1/31

N2 - Neuropeptides are involved in numerous brain activities being able to control a wide spectrum of physiological functions. In recent years, a number of novel pleiotropic regulatory peptides have been discovered in animal brain structures. The purpose of this descriptive neurochemical investigation was to detect the possible expression of the novel multifunctional neuropeptides spexin (SPX) and nesfatin-1 within the human brainstem. Using immunohistochemical and fluorescence techniques, neuroanatomical analysis of the SPX and nesfatin-1 expression and distribution was performed in selected sections of the human midbrain and medulla oblongata. The presence of SPX-positive neurons in the human brainstem was revealed for the first time and previous reports on the expression of nesfatin-1 were additionally confirmed. The research results suggest that SPX and nesfatin-1 are new regulatory neuropeptides of the human brainstem potentially involved in the regulation of key autonomic activities of this brain region.

AB - Neuropeptides are involved in numerous brain activities being able to control a wide spectrum of physiological functions. In recent years, a number of novel pleiotropic regulatory peptides have been discovered in animal brain structures. The purpose of this descriptive neurochemical investigation was to detect the possible expression of the novel multifunctional neuropeptides spexin (SPX) and nesfatin-1 within the human brainstem. Using immunohistochemical and fluorescence techniques, neuroanatomical analysis of the SPX and nesfatin-1 expression and distribution was performed in selected sections of the human midbrain and medulla oblongata. The presence of SPX-positive neurons in the human brainstem was revealed for the first time and previous reports on the expression of nesfatin-1 were additionally confirmed. The research results suggest that SPX and nesfatin-1 are new regulatory neuropeptides of the human brainstem potentially involved in the regulation of key autonomic activities of this brain region.

U2 - 10.1016/j.npep.2024.102484

DO - 10.1016/j.npep.2024.102484

M3 - Journal article

VL - 109

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

M1 - 102484

ER -