Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease

Biomedical and Life Sciences

Keywords

Adult, Aged, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Dementia, Humans, Immunohistochemistry, Male, Microscopy, Polarization, Middle Aged, Neurofibrils

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease. / Allsop, D; Haga, S; Bruton, C et al.
In: American Journal of Pathology, Vol. 136, No. 2, 02.1990, p. 255-260.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{fe624f69d924426a9dd9c4f8e4702469,

title = "Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease",

abstract = "Formalin-fixed, paraffin-embedded temporal lobe sections from eight former boxers' brains were examined using an immunohistochemical method with antibodies to amyloid beta protein. In accord with recent observations in Alzheimer's disease, significant numbers of beta-protein immunoreactive neurofibrillary tangles (NFT) were observed in three cases. Most of these immunoreactive NFTs appeared to be tombstone tangles, although not all such tangles were stained. This immunoreaction was completely abolished by preincubation of antibodies with synthetic beta-protein peptides, and the identity of the immunostained NFTs was confirmed by polarization microscopy of sections counterstained with Congo red. However, it is not yet clear if the beta-protein antigens are, in fact, an integral part of paired helical filaments. These observations, together with our recent finding of beta-immunoreactive plaque-like lesions in dementia pugilistica, also emphasize the many similarities in pathology between this condition and Alzheimer's disease.",

keywords = "Adult, Aged, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Dementia, Humans, Immunohistochemistry, Male, Microscopy, Polarization, Middle Aged, Neurofibrils",

author = "D Allsop and S Haga and C Bruton and T Ishii and Roberts, {G W}",

year = "1990",

month = feb,

language = "English",

volume = "136",

pages = "255--260",

journal = "American Journal of Pathology",

issn = "0002-9440",

publisher = "Elsevier Inc.",

number = "2",

}

RIS

TY - JOUR

T1 - Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease

AU - Allsop, D

AU - Haga, S

AU - Bruton, C

AU - Ishii, T

AU - Roberts, G W

PY - 1990/2

Y1 - 1990/2

N2 - Formalin-fixed, paraffin-embedded temporal lobe sections from eight former boxers' brains were examined using an immunohistochemical method with antibodies to amyloid beta protein. In accord with recent observations in Alzheimer's disease, significant numbers of beta-protein immunoreactive neurofibrillary tangles (NFT) were observed in three cases. Most of these immunoreactive NFTs appeared to be tombstone tangles, although not all such tangles were stained. This immunoreaction was completely abolished by preincubation of antibodies with synthetic beta-protein peptides, and the identity of the immunostained NFTs was confirmed by polarization microscopy of sections counterstained with Congo red. However, it is not yet clear if the beta-protein antigens are, in fact, an integral part of paired helical filaments. These observations, together with our recent finding of beta-immunoreactive plaque-like lesions in dementia pugilistica, also emphasize the many similarities in pathology between this condition and Alzheimer's disease.

AB - Formalin-fixed, paraffin-embedded temporal lobe sections from eight former boxers' brains were examined using an immunohistochemical method with antibodies to amyloid beta protein. In accord with recent observations in Alzheimer's disease, significant numbers of beta-protein immunoreactive neurofibrillary tangles (NFT) were observed in three cases. Most of these immunoreactive NFTs appeared to be tombstone tangles, although not all such tangles were stained. This immunoreaction was completely abolished by preincubation of antibodies with synthetic beta-protein peptides, and the identity of the immunostained NFTs was confirmed by polarization microscopy of sections counterstained with Congo red. However, it is not yet clear if the beta-protein antigens are, in fact, an integral part of paired helical filaments. These observations, together with our recent finding of beta-immunoreactive plaque-like lesions in dementia pugilistica, also emphasize the many similarities in pathology between this condition and Alzheimer's disease.

KW - Adult

KW - Aged

KW - Alzheimer Disease

KW - Amyloid

KW - Amyloid beta-Peptides

KW - Dementia

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Microscopy, Polarization

KW - Middle Aged

KW - Neurofibrils

M3 - Journal article

C2 - 2407121

VL - 136

SP - 255

EP - 260

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 2

ER -

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