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Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

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Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid. / Deckmann, Iohanna; Schwingel, Gustavo Brum; Fontes-Dutra, Mellanie et al.
In: Neuroimmunomodulation, Vol. 25, No. 5-6, 2018, p. 285-299.

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Deckmann I, Schwingel GB, Fontes-Dutra M, Bambini-Junior V, Gottfried C. Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid. Neuroimmunomodulation. 2018;25(5-6):285-299. doi: 10.1159/000492113

Author

Deckmann, Iohanna ; Schwingel, Gustavo Brum ; Fontes-Dutra, Mellanie et al. / Neuroimmune Alterations in Autism : A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid. In: Neuroimmunomodulation. 2018 ; Vol. 25, No. 5-6. pp. 285-299.

Bibtex

@article{ed40e9b1422d4534923be4707eae4a0e,
title = "Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid",
abstract = "Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized by deficits in communication and social interaction and in stereotyped or repetitive behaviors. Besides the classical behavioral dyad, several comorbidities are frequently present in patients with ASD, such as anxiety, epilepsy, sleep disturbances, and gastrointestinal tract dysfunction. Although the etiology of ASD remains unclear, there is supporting evidence for the involvement of both genetic and environmental factors. Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, increases the risk of ASD in the offspring. The animal model of autism induced by prenatal exposure to VPA demonstrates important structural and behavioral features that can be observed in individuals with autism; it is thus an excellent tool for testing new drug targets and developing novel behavioral and drug therapies. In addition, immunological alterations during pregnancy could affect the developing embryo because immune molecules can pass through the placental barrier. In fact, exposure to pathogens during the pregnancy is a known risk factor for ASD, and maternal immune activation can lead to autistic-like features in animals. Interestingly, neuroimmune alterations are common in both autistic individuals and in animal models of ASD. We summarize here the important alterations in inflammatory markers, such as cytokines and chemokines, in patients with ASD and in the VPA animal model.",
keywords = "Animals, Autistic Disorder/chemically induced, Disease Models, Animal, Enzyme Inhibitors/toxicity, Female, Humans, Mice, Neuroimmunomodulation/immunology, Pregnancy, Prenatal Exposure Delayed Effects, Valproic Acid/toxicity",
author = "Iohanna Deckmann and Schwingel, {Gustavo Brum} and Mellanie Fontes-Dutra and Victorio Bambini-Junior and Carmem Gottfried",
note = "{\textcopyright} 2018 S. Karger AG, Basel.",
year = "2018",
doi = "10.1159/000492113",
language = "English",
volume = "25",
pages = "285--299",
journal = "Neuroimmunomodulation",
issn = "1021-7401",
publisher = "S. Karger AG",
number = "5-6",

}

RIS

TY - JOUR

T1 - Neuroimmune Alterations in Autism

T2 - A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

AU - Deckmann, Iohanna

AU - Schwingel, Gustavo Brum

AU - Fontes-Dutra, Mellanie

AU - Bambini-Junior, Victorio

AU - Gottfried, Carmem

N1 - © 2018 S. Karger AG, Basel.

PY - 2018

Y1 - 2018

N2 - Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized by deficits in communication and social interaction and in stereotyped or repetitive behaviors. Besides the classical behavioral dyad, several comorbidities are frequently present in patients with ASD, such as anxiety, epilepsy, sleep disturbances, and gastrointestinal tract dysfunction. Although the etiology of ASD remains unclear, there is supporting evidence for the involvement of both genetic and environmental factors. Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, increases the risk of ASD in the offspring. The animal model of autism induced by prenatal exposure to VPA demonstrates important structural and behavioral features that can be observed in individuals with autism; it is thus an excellent tool for testing new drug targets and developing novel behavioral and drug therapies. In addition, immunological alterations during pregnancy could affect the developing embryo because immune molecules can pass through the placental barrier. In fact, exposure to pathogens during the pregnancy is a known risk factor for ASD, and maternal immune activation can lead to autistic-like features in animals. Interestingly, neuroimmune alterations are common in both autistic individuals and in animal models of ASD. We summarize here the important alterations in inflammatory markers, such as cytokines and chemokines, in patients with ASD and in the VPA animal model.

AB - Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized by deficits in communication and social interaction and in stereotyped or repetitive behaviors. Besides the classical behavioral dyad, several comorbidities are frequently present in patients with ASD, such as anxiety, epilepsy, sleep disturbances, and gastrointestinal tract dysfunction. Although the etiology of ASD remains unclear, there is supporting evidence for the involvement of both genetic and environmental factors. Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, increases the risk of ASD in the offspring. The animal model of autism induced by prenatal exposure to VPA demonstrates important structural and behavioral features that can be observed in individuals with autism; it is thus an excellent tool for testing new drug targets and developing novel behavioral and drug therapies. In addition, immunological alterations during pregnancy could affect the developing embryo because immune molecules can pass through the placental barrier. In fact, exposure to pathogens during the pregnancy is a known risk factor for ASD, and maternal immune activation can lead to autistic-like features in animals. Interestingly, neuroimmune alterations are common in both autistic individuals and in animal models of ASD. We summarize here the important alterations in inflammatory markers, such as cytokines and chemokines, in patients with ASD and in the VPA animal model.

KW - Animals

KW - Autistic Disorder/chemically induced

KW - Disease Models, Animal

KW - Enzyme Inhibitors/toxicity

KW - Female

KW - Humans

KW - Mice

KW - Neuroimmunomodulation/immunology

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Valproic Acid/toxicity

U2 - 10.1159/000492113

DO - 10.1159/000492113

M3 - Review article

C2 - 30157484

VL - 25

SP - 285

EP - 299

JO - Neuroimmunomodulation

JF - Neuroimmunomodulation

SN - 1021-7401

IS - 5-6

ER -