Home > Research > Publications & Outputs > Neurotrophin signaling in medulloblastoma

Research

Links

Text available via DOI:

Keywords

View graph of relations

Neurotrophin signaling in medulloblastoma

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Neurotrophin signaling in medulloblastoma. / Thomaz, Amanda; Jaeger, Mariane; Brunetto, Algemir L. et al.
In: Cancers, Vol. 12, No. 9, 2542, 07.09.2020, p. 1-22.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Thomaz, A, Jaeger, M, Brunetto, AL, Brunetto, AT, Gregianin, L, de Farias, CB, Ramaswamy, V, Nör, C, Taylor, MD & Roesler, R 2020, 'Neurotrophin signaling in medulloblastoma', Cancers, vol. 12, no. 9, 2542, pp. 1-22. https://doi.org/10.3390/cancers12092542

APA

Thomaz, A., Jaeger, M., Brunetto, A. L., Brunetto, A. T., Gregianin, L., de Farias, C. B., Ramaswamy, V., Nör, C., Taylor, M. D., & Roesler, R. (2020). Neurotrophin signaling in medulloblastoma. Cancers, 12(9), 1-22. Article 2542. https://doi.org/10.3390/cancers12092542

Vancouver

Thomaz A, Jaeger M, Brunetto AL, Brunetto AT, Gregianin L, de Farias CB et al. Neurotrophin signaling in medulloblastoma. Cancers. 2020 Sept 7;12(9):1-22. 2542. doi: 10.3390/cancers12092542

Author

Thomaz, Amanda ; Jaeger, Mariane ; Brunetto, Algemir L. et al. / Neurotrophin signaling in medulloblastoma. In: Cancers. 2020 ; Vol. 12, No. 9. pp. 1-22.

Bibtex

@article{e19c92bb2c5f4a8886d2e35283a18831,
title = "Neurotrophin signaling in medulloblastoma",
abstract = "Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment. In this review, we summarize evidence indicating that neurotrophin signaling influences medulloblastoma (MB), the most common type of malignant brain cancer afflicting children. We discuss the potential of neurotrophin receptors as new therapeutic targets for the treatment of MB. Overall, activation of TrkA and TrkC types of receptors seem to promote cell death, whereas TrkB might stimulate MB growth, and TrkB inhibition displays antitumor effects. Importantly, we show analyses of the gene expression profile of neurotrophins and their receptors in MB primary tumors, which indicate, among other findings, that higher levels of NTRK1 or NTRK2 are associated with reduced overall survival (OS) of patients with SHH MB tumors.",
keywords = "Brain tumor, Brain-derived neurotrophic factor, Medulloblastoma, Nerve growth factor, Neurotrophin, Tropomyosin receptor kinase",
author = "Amanda Thomaz and Mariane Jaeger and Brunetto, {Algemir L.} and Brunetto, {Andr{\'e} T.} and Lauro Gregianin and {de Farias}, {Caroline Brunetto} and Vijay Ramaswamy and Carolina N{\"o}r and Taylor, {Michael D.} and Rafael Roesler",
year = "2020",
month = sep,
day = "7",
doi = "10.3390/cancers12092542",
language = "English",
volume = "12",
pages = "1--22",
journal = "Cancers",
issn = "2072-6694",
publisher = "MDPI",
number = "9",

}

RIS

TY - JOUR

T1 - Neurotrophin signaling in medulloblastoma

AU - Thomaz, Amanda

AU - Jaeger, Mariane

AU - Brunetto, Algemir L.

AU - Brunetto, André T.

AU - Gregianin, Lauro

AU - de Farias, Caroline Brunetto

AU - Ramaswamy, Vijay

AU - Nör, Carolina

AU - Taylor, Michael D.

AU - Roesler, Rafael

PY - 2020/9/7

Y1 - 2020/9/7

N2 - Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment. In this review, we summarize evidence indicating that neurotrophin signaling influences medulloblastoma (MB), the most common type of malignant brain cancer afflicting children. We discuss the potential of neurotrophin receptors as new therapeutic targets for the treatment of MB. Overall, activation of TrkA and TrkC types of receptors seem to promote cell death, whereas TrkB might stimulate MB growth, and TrkB inhibition displays antitumor effects. Importantly, we show analyses of the gene expression profile of neurotrophins and their receptors in MB primary tumors, which indicate, among other findings, that higher levels of NTRK1 or NTRK2 are associated with reduced overall survival (OS) of patients with SHH MB tumors.

AB - Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment. In this review, we summarize evidence indicating that neurotrophin signaling influences medulloblastoma (MB), the most common type of malignant brain cancer afflicting children. We discuss the potential of neurotrophin receptors as new therapeutic targets for the treatment of MB. Overall, activation of TrkA and TrkC types of receptors seem to promote cell death, whereas TrkB might stimulate MB growth, and TrkB inhibition displays antitumor effects. Importantly, we show analyses of the gene expression profile of neurotrophins and their receptors in MB primary tumors, which indicate, among other findings, that higher levels of NTRK1 or NTRK2 are associated with reduced overall survival (OS) of patients with SHH MB tumors.

KW - Brain tumor

KW - Brain-derived neurotrophic factor

KW - Medulloblastoma

KW - Nerve growth factor

KW - Neurotrophin

KW - Tropomyosin receptor kinase

U2 - 10.3390/cancers12092542

DO - 10.3390/cancers12092542

M3 - Journal article

AN - SCOPUS:85090329000

VL - 12

SP - 1

EP - 22

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 9

M1 - 2542

ER -