Research output: Contribution to Journal/Magazine › Journal article › peer-review
Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting : a feasibility study using a randomized controlled trial design. / Moradian, Saeed; Walshe, Catherine; Shahidsales, Soodabeh et al.
In: European Journal of Oncology Nursing, Vol. 19, No. 3, 06.2015, p. 282-291.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting
T2 - a feasibility study using a randomized controlled trial design
AU - Moradian, Saeed
AU - Walshe, Catherine
AU - Shahidsales, Soodabeh
AU - Ghavam Nasiri, Moammad Reza
AU - Pilling, Mark
AU - Molassiotis, Alex
PY - 2015/6
Y1 - 2015/6
N2 - PurposePharmacological therapy is only partially effective in preventing or treating chemotherapy induced nausea and vomiting (CINV). Therefore, exploring the complementary role of non-pharmacological approaches used in addition to pharmacological agents is important. Nevasic uses specially constructed audio signals hypothesized to generate an antiemetic reaction. The aim of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) to evaluate the effectiveness of Nevasic to control CINV.MethodsA mixed methods design incorporating an RCT and focus group interviews. For the RCT, female breast cancer patients were randomized to receive either Nevasic plus usual care, music plus usual care, or usual care only. Data were analyzed using descriptive statistics and linear mixed-effects models. Five focus group interviews were conducted to obtain participants’ views regarding the acceptability of the interventions in the trial.Results99 participants were recruited to the RCT and 15 participated in focus group interviews. Recruitment targets were achieved. Issues of Nevasic acceptability were highlighted as weaknesses of the program. This study did not detect any evidence for the effectiveness of Nevasic; however, the results showed statistically significant less use of anti-emetics (p=0.003) and borderline non-significant improvement in quality of life (p=0.06).ConclusionsConducting a non-pharmacological intervention using such an audio program is feasible, although difficulties and limitations exist with its use. Further studies are required to investigate the effectiveness of Nevasic from perspectives such as anti-emetic use, as well as its overall effect on the levels of nausea and vomiting.
AB - PurposePharmacological therapy is only partially effective in preventing or treating chemotherapy induced nausea and vomiting (CINV). Therefore, exploring the complementary role of non-pharmacological approaches used in addition to pharmacological agents is important. Nevasic uses specially constructed audio signals hypothesized to generate an antiemetic reaction. The aim of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) to evaluate the effectiveness of Nevasic to control CINV.MethodsA mixed methods design incorporating an RCT and focus group interviews. For the RCT, female breast cancer patients were randomized to receive either Nevasic plus usual care, music plus usual care, or usual care only. Data were analyzed using descriptive statistics and linear mixed-effects models. Five focus group interviews were conducted to obtain participants’ views regarding the acceptability of the interventions in the trial.Results99 participants were recruited to the RCT and 15 participated in focus group interviews. Recruitment targets were achieved. Issues of Nevasic acceptability were highlighted as weaknesses of the program. This study did not detect any evidence for the effectiveness of Nevasic; however, the results showed statistically significant less use of anti-emetics (p=0.003) and borderline non-significant improvement in quality of life (p=0.06).ConclusionsConducting a non-pharmacological intervention using such an audio program is feasible, although difficulties and limitations exist with its use. Further studies are required to investigate the effectiveness of Nevasic from perspectives such as anti-emetic use, as well as its overall effect on the levels of nausea and vomiting.
KW - Chemotherapy-induced nausea and vomiting
KW - Nevasic
KW - Music therapy
KW - Feasibility
U2 - 10.1016/j.ejon.2014.10.016
DO - 10.1016/j.ejon.2014.10.016
M3 - Journal article
VL - 19
SP - 282
EP - 291
JO - European Journal of Oncology Nursing
JF - European Journal of Oncology Nursing
SN - 1462-3889
IS - 3
ER -