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Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting: a feasibility study using a randomized controlled trial design

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Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting : a feasibility study using a randomized controlled trial design. / Moradian, Saeed; Walshe, Catherine; Shahidsales, Soodabeh; Ghavam Nasiri, Moammad Reza; Pilling, Mark; Molassiotis, Alex.

In: European Journal of Oncology Nursing, Vol. 19, No. 3, 06.2015, p. 282-291.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Moradian, S, Walshe, C, Shahidsales, S, Ghavam Nasiri, MR, Pilling, M & Molassiotis, A 2015, 'Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting: a feasibility study using a randomized controlled trial design', European Journal of Oncology Nursing, vol. 19, no. 3, pp. 282-291. https://doi.org/10.1016/j.ejon.2014.10.016

APA

Moradian, S., Walshe, C., Shahidsales, S., Ghavam Nasiri, M. R., Pilling, M., & Molassiotis, A. (2015). Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting: a feasibility study using a randomized controlled trial design. European Journal of Oncology Nursing, 19(3), 282-291. https://doi.org/10.1016/j.ejon.2014.10.016

Vancouver

Moradian S, Walshe C, Shahidsales S, Ghavam Nasiri MR, Pilling M, Molassiotis A. Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting: a feasibility study using a randomized controlled trial design. European Journal of Oncology Nursing. 2015 Jun;19(3):282-291. https://doi.org/10.1016/j.ejon.2014.10.016

Author

Moradian, Saeed ; Walshe, Catherine ; Shahidsales, Soodabeh ; Ghavam Nasiri, Moammad Reza ; Pilling, Mark ; Molassiotis, Alex. / Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting : a feasibility study using a randomized controlled trial design. In: European Journal of Oncology Nursing. 2015 ; Vol. 19, No. 3. pp. 282-291.

Bibtex

@article{5faae925a4c6476a9407f5bf787204b9,
title = "Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting: a feasibility study using a randomized controlled trial design",
abstract = "PurposePharmacological therapy is only partially effective in preventing or treating chemotherapy induced nausea and vomiting (CINV). Therefore, exploring the complementary role of non-pharmacological approaches used in addition to pharmacological agents is important. Nevasic uses specially constructed audio signals hypothesized to generate an antiemetic reaction. The aim of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) to evaluate the effectiveness of Nevasic to control CINV.MethodsA mixed methods design incorporating an RCT and focus group interviews. For the RCT, female breast cancer patients were randomized to receive either Nevasic plus usual care, music plus usual care, or usual care only. Data were analyzed using descriptive statistics and linear mixed-effects models. Five focus group interviews were conducted to obtain participants{\textquoteright} views regarding the acceptability of the interventions in the trial.Results99 participants were recruited to the RCT and 15 participated in focus group interviews. Recruitment targets were achieved. Issues of Nevasic acceptability were highlighted as weaknesses of the program. This study did not detect any evidence for the effectiveness of Nevasic; however, the results showed statistically significant less use of anti-emetics (p=0.003) and borderline non-significant improvement in quality of life (p=0.06).ConclusionsConducting a non-pharmacological intervention using such an audio program is feasible, although difficulties and limitations exist with its use. Further studies are required to investigate the effectiveness of Nevasic from perspectives such as anti-emetic use, as well as its overall effect on the levels of nausea and vomiting.",
keywords = "Chemotherapy-induced nausea and vomiting, Nevasic, Music therapy, Feasibility",
author = "Saeed Moradian and Catherine Walshe and Soodabeh Shahidsales and {Ghavam Nasiri}, {Moammad Reza} and Mark Pilling and Alex Molassiotis",
year = "2015",
month = jun,
doi = "10.1016/j.ejon.2014.10.016",
language = "English",
volume = "19",
pages = "282--291",
journal = "European Journal of Oncology Nursing",
issn = "1462-3889",
publisher = "Churchill Livingstone",
number = "3",

}

RIS

TY - JOUR

T1 - Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting

T2 - a feasibility study using a randomized controlled trial design

AU - Moradian, Saeed

AU - Walshe, Catherine

AU - Shahidsales, Soodabeh

AU - Ghavam Nasiri, Moammad Reza

AU - Pilling, Mark

AU - Molassiotis, Alex

PY - 2015/6

Y1 - 2015/6

N2 - PurposePharmacological therapy is only partially effective in preventing or treating chemotherapy induced nausea and vomiting (CINV). Therefore, exploring the complementary role of non-pharmacological approaches used in addition to pharmacological agents is important. Nevasic uses specially constructed audio signals hypothesized to generate an antiemetic reaction. The aim of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) to evaluate the effectiveness of Nevasic to control CINV.MethodsA mixed methods design incorporating an RCT and focus group interviews. For the RCT, female breast cancer patients were randomized to receive either Nevasic plus usual care, music plus usual care, or usual care only. Data were analyzed using descriptive statistics and linear mixed-effects models. Five focus group interviews were conducted to obtain participants’ views regarding the acceptability of the interventions in the trial.Results99 participants were recruited to the RCT and 15 participated in focus group interviews. Recruitment targets were achieved. Issues of Nevasic acceptability were highlighted as weaknesses of the program. This study did not detect any evidence for the effectiveness of Nevasic; however, the results showed statistically significant less use of anti-emetics (p=0.003) and borderline non-significant improvement in quality of life (p=0.06).ConclusionsConducting a non-pharmacological intervention using such an audio program is feasible, although difficulties and limitations exist with its use. Further studies are required to investigate the effectiveness of Nevasic from perspectives such as anti-emetic use, as well as its overall effect on the levels of nausea and vomiting.

AB - PurposePharmacological therapy is only partially effective in preventing or treating chemotherapy induced nausea and vomiting (CINV). Therefore, exploring the complementary role of non-pharmacological approaches used in addition to pharmacological agents is important. Nevasic uses specially constructed audio signals hypothesized to generate an antiemetic reaction. The aim of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) to evaluate the effectiveness of Nevasic to control CINV.MethodsA mixed methods design incorporating an RCT and focus group interviews. For the RCT, female breast cancer patients were randomized to receive either Nevasic plus usual care, music plus usual care, or usual care only. Data were analyzed using descriptive statistics and linear mixed-effects models. Five focus group interviews were conducted to obtain participants’ views regarding the acceptability of the interventions in the trial.Results99 participants were recruited to the RCT and 15 participated in focus group interviews. Recruitment targets were achieved. Issues of Nevasic acceptability were highlighted as weaknesses of the program. This study did not detect any evidence for the effectiveness of Nevasic; however, the results showed statistically significant less use of anti-emetics (p=0.003) and borderline non-significant improvement in quality of life (p=0.06).ConclusionsConducting a non-pharmacological intervention using such an audio program is feasible, although difficulties and limitations exist with its use. Further studies are required to investigate the effectiveness of Nevasic from perspectives such as anti-emetic use, as well as its overall effect on the levels of nausea and vomiting.

KW - Chemotherapy-induced nausea and vomiting

KW - Nevasic

KW - Music therapy

KW - Feasibility

U2 - 10.1016/j.ejon.2014.10.016

DO - 10.1016/j.ejon.2014.10.016

M3 - Journal article

VL - 19

SP - 282

EP - 291

JO - European Journal of Oncology Nursing

JF - European Journal of Oncology Nursing

SN - 1462-3889

IS - 3

ER -