Home > Research > Publications & Outputs > Newly crosslinked chitosan- and chitosan-pectin...

Research

Electronic data

  • CARBPOL-D-21-04557_R3

    Accepted author manuscript, 7.19 MB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

Links

Text available via DOI:

Keywords

View graph of relations

Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity. / Dziadek, Michal; Dziadek, Kinga; Salagierski, Szymon et al.
In: Carbohydrate Polymers, Vol. 290, 119486, 15.08.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Dziadek, M, Dziadek, K, Salagierski, S, Drozdowska, M, Serafim, A, Stancu, I-C, Szatkowski, P, Kopec, A, Rajzer, I, Douglas, T & Cholewa-Kowalska, K 2022, 'Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity', Carbohydrate Polymers, vol. 290, 119486. https://doi.org/10.1016/j.carbpol.2022.119486

APA

Dziadek, M., Dziadek, K., Salagierski, S., Drozdowska, M., Serafim, A., Stancu, I-C., Szatkowski, P., Kopec, A., Rajzer, I., Douglas, T., & Cholewa-Kowalska, K. (2022). Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity. Carbohydrate Polymers, 290, Article 119486. https://doi.org/10.1016/j.carbpol.2022.119486

Vancouver

Dziadek M, Dziadek K, Salagierski S, Drozdowska M, Serafim A, Stancu I-C et al. Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity. Carbohydrate Polymers. 2022 Aug 15;290:119486. Epub 2022 Apr 16. doi: 10.1016/j.carbpol.2022.119486

Author

Dziadek, Michal ; Dziadek, Kinga ; Salagierski, Szymon et al. / Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity. In: Carbohydrate Polymers. 2022 ; Vol. 290.

Bibtex

@article{2f4f32264a9a4c51871a68a6cf9332b5,
title = "Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity",
abstract = "Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications. However, most studies have focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA). All of these were not only involved in the crosslinking, but also modulated properties or imparted completely new ones. THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells. Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS. All hydrogels modified with BG exhibited the ability to mineralise in SBF. The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.",
keywords = "Monoaldehyde, Polyelectrolyte complex, Bioactive glass, Polyphenols, micro-computed tomography",
author = "Michal Dziadek and Kinga Dziadek and Szymon Salagierski and Mariola Drozdowska and Andrada Serafim and Izabela-Cristina Stancu and Piotr Szatkowski and Aneta Kopec and Izabella Rajzer and Timothy Douglas and Katarzyna Cholewa-Kowalska",
year = "2022",
month = aug,
day = "15",
doi = "10.1016/j.carbpol.2022.119486",
language = "English",
volume = "290",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

AU - Dziadek, Michal

AU - Dziadek, Kinga

AU - Salagierski, Szymon

AU - Drozdowska, Mariola

AU - Serafim, Andrada

AU - Stancu, Izabela-Cristina

AU - Szatkowski, Piotr

AU - Kopec, Aneta

AU - Rajzer, Izabella

AU - Douglas, Timothy

AU - Cholewa-Kowalska, Katarzyna

PY - 2022/8/15

Y1 - 2022/8/15

N2 - Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications. However, most studies have focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA). All of these were not only involved in the crosslinking, but also modulated properties or imparted completely new ones. THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells. Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS. All hydrogels modified with BG exhibited the ability to mineralise in SBF. The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.

AB - Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications. However, most studies have focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA). All of these were not only involved in the crosslinking, but also modulated properties or imparted completely new ones. THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells. Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS. All hydrogels modified with BG exhibited the ability to mineralise in SBF. The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.

KW - Monoaldehyde

KW - Polyelectrolyte complex

KW - Bioactive glass

KW - Polyphenols

KW - micro-computed tomography

U2 - 10.1016/j.carbpol.2022.119486

DO - 10.1016/j.carbpol.2022.119486

M3 - Journal article

VL - 290

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

M1 - 119486

ER -