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No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia: a pre-planned subgroup analysis of the seven-country PACE trial

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No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia: a pre-planned subgroup analysis of the seven-country PACE trial. / Miranda, R.; Smets, T.; Van Den Noortgate, N. et al.
In: BMC Palliative Care, Vol. 20, No. 1, 39, 07.03.2021.

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Harvard

Miranda, R, Smets, T, Van Den Noortgate, N, van der Steen, JT, Deliens, L, Payne, S, Szczerbińska, K, Pautex, S, Van Humbeeck, L, Gambassi, G, Kylänen, M, Van den Block, L, Gatsolaeva, Y, Pivodic, L, Honinx, E, Tanghe, M, van Hout, H, Froggatt, K, Onwuteaka-Philipsen, B, Pasman, HRW, Piers, R, Baranska, I, Oosterveld-Vlug, M, Wichmann, AB, Engels, Y, Vernooij-Dassen, M, Hockley, J, Leppäaho, S, Bassal, C, Mammarella, F, Mercuri, M, Rossi, P, Segat, I, Stodolska, A, Adang, E, Andreasen, P, Kuitunen-Kaija, O, Hammar, T, Heikkilä, R, Moore, DC, Kijowska, V, ten Koppel, M, de Paula, EM & PACE, OBO 2021, 'No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia: a pre-planned subgroup analysis of the seven-country PACE trial', BMC Palliative Care, vol. 20, no. 1, 39. https://doi.org/10.1186/s12904-021-00734-1

APA

Miranda, R., Smets, T., Van Den Noortgate, N., van der Steen, J. T., Deliens, L., Payne, S., Szczerbińska, K., Pautex, S., Van Humbeeck, L., Gambassi, G., Kylänen, M., Van den Block, L., Gatsolaeva, Y., Pivodic, L., Honinx, E., Tanghe, M., van Hout, H., Froggatt, K., Onwuteaka-Philipsen, B., ... PACE, O. B. O. (2021). No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia: a pre-planned subgroup analysis of the seven-country PACE trial. BMC Palliative Care, 20(1), Article 39. https://doi.org/10.1186/s12904-021-00734-1

Vancouver

Miranda R, Smets T, Van Den Noortgate N, van der Steen JT, Deliens L, Payne S et al. No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia: a pre-planned subgroup analysis of the seven-country PACE trial. BMC Palliative Care. 2021 Mar 7;20(1):39. doi: 10.1186/s12904-021-00734-1

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@article{27e49e6c33cc45499ee11326f410e4a5,
title = "No difference in effects of {\textquoteleft}PACE steps to success{\textquoteright} palliative care program for nursing home residents with and without dementia: a pre-planned subgroup analysis of the seven-country PACE trial",
abstract = "Background: {\textquoteleft}PACE Steps to Success{\textquoteright} is a multicomponent training program aiming to integrate generalist and non-disease-specific palliative care in nursing homes. This program did not improve residents{\textquoteright} comfort in the last week of life, but it appeared to improve quality of care and dying in their last month of life. Because this program included only three dementia-specific elements, its effects might differ depending on the presence or stage of dementia. We aimed to investigate whether the program effects differ between residents with advanced, non-advanced, and no dementia. Methods: Pre-planned subgroup analysis of the PACE cluster-randomized controlled trial in 78 nursing homes in seven European countries. Participants included residents who died in the previous 4 months. The nursing home staff or general practitioner assessed the presence of dementia; severity was determined using two highly-discriminatory staff-reported instruments. Using after-death questionnaires, staff assessed comfort in the last week of life (Comfort Assessment in Dying–End-of-Life in Dementia-scale; primary outcome) and quality of care and dying in the last month of life (Quality of Dying in Long-Term Care scale; secondary outcome). Results: At baseline, we included 177 residents with advanced dementia, 126 with non-advanced dementia and 156 without dementia. Post-intervention, respectively in the control and the intervention group, we included 136 and 104 residents with advanced dementia, 167 and 110 with non-advanced dementia and 157 and 137 without dementia. We found no subgroup differences on comfort in the last week of life, comparing advanced versus without dementia (baseline-adjusted mean sub-group difference 2.1; p-value = 0.177), non-advanced versus without dementia (2.7; p = 0.092), and advanced versus non-advanced dementia (− 0.6; p = 0.698); or on quality of care and dying in the last month of life, comparing advanced and without dementia (− 0.6; p = 0.741), non-advanced and without dementia (− 1.5; p = 0.428), and advanced and non-advanced dementia (0.9; p = 0.632). Conclusions: The lack of subgroup difference suggests that while the program did not improve comfort in dying residents with or without dementia, it appeared to equally improve quality of care and dying in the last month of life for residents with dementia (regardless of the stage) and those without dementia. A generalist and non-disease-specific palliative care program, such as PACE Steps to Success, is a useful starting point for future palliative care improvement in nursing homes, but to effectively improve residents{\textquoteright} comfort, this program needs further development. Trial registration: ISRCTN, ISRCTN14741671. Registered 8 July 2015 – Retrospectively registered. ",
keywords = "Bereavement, Communication, End of life care, Neurological conditions, Nursing home care, Pain",
author = "R. Miranda and T. Smets and {Van Den Noortgate}, N. and {van der Steen}, J.T. and L. Deliens and S. Payne and K. Szczerbi{\'n}ska and S. Pautex and {Van Humbeeck}, L. and G. Gambassi and M. Kyl{\"a}nen and {Van den Block}, L. and Y. Gatsolaeva and L. Pivodic and E. Honinx and M. Tanghe and {van Hout}, H. and K. Froggatt and B. Onwuteaka-Philipsen and H.R.W. Pasman and R. Piers and I. Baranska and M. Oosterveld-Vlug and A.B. Wichmann and Y. Engels and M. Vernooij-Dassen and J. Hockley and S. Lepp{\"a}aho and C. Bassal and F. Mammarella and M. Mercuri and P. Rossi and I. Segat and A. Stodolska and E. Adang and P. Andreasen and O. Kuitunen-Kaija and T. Hammar and R. Heikkil{\"a} and D.C. Moore and V. Kijowska and {ten Koppel}, M. and {de Paula}, E.M. and PACE, {on behalf of}",
year = "2021",
month = mar,
day = "7",
doi = "10.1186/s12904-021-00734-1",
language = "English",
volume = "20",
journal = "BMC Palliative Care",
issn = "1472-684X",
publisher = "BIOMED CENTRAL LTD",
number = "1",

}

RIS

TY - JOUR

T1 - No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia

T2 - a pre-planned subgroup analysis of the seven-country PACE trial

AU - Miranda, R.

AU - Smets, T.

AU - Van Den Noortgate, N.

AU - van der Steen, J.T.

AU - Deliens, L.

AU - Payne, S.

AU - Szczerbińska, K.

AU - Pautex, S.

AU - Van Humbeeck, L.

AU - Gambassi, G.

AU - Kylänen, M.

AU - Van den Block, L.

AU - Gatsolaeva, Y.

AU - Pivodic, L.

AU - Honinx, E.

AU - Tanghe, M.

AU - van Hout, H.

AU - Froggatt, K.

AU - Onwuteaka-Philipsen, B.

AU - Pasman, H.R.W.

AU - Piers, R.

AU - Baranska, I.

AU - Oosterveld-Vlug, M.

AU - Wichmann, A.B.

AU - Engels, Y.

AU - Vernooij-Dassen, M.

AU - Hockley, J.

AU - Leppäaho, S.

AU - Bassal, C.

AU - Mammarella, F.

AU - Mercuri, M.

AU - Rossi, P.

AU - Segat, I.

AU - Stodolska, A.

AU - Adang, E.

AU - Andreasen, P.

AU - Kuitunen-Kaija, O.

AU - Hammar, T.

AU - Heikkilä, R.

AU - Moore, D.C.

AU - Kijowska, V.

AU - ten Koppel, M.

AU - de Paula, E.M.

AU - PACE, on behalf of

PY - 2021/3/7

Y1 - 2021/3/7

N2 - Background: ‘PACE Steps to Success’ is a multicomponent training program aiming to integrate generalist and non-disease-specific palliative care in nursing homes. This program did not improve residents’ comfort in the last week of life, but it appeared to improve quality of care and dying in their last month of life. Because this program included only three dementia-specific elements, its effects might differ depending on the presence or stage of dementia. We aimed to investigate whether the program effects differ between residents with advanced, non-advanced, and no dementia. Methods: Pre-planned subgroup analysis of the PACE cluster-randomized controlled trial in 78 nursing homes in seven European countries. Participants included residents who died in the previous 4 months. The nursing home staff or general practitioner assessed the presence of dementia; severity was determined using two highly-discriminatory staff-reported instruments. Using after-death questionnaires, staff assessed comfort in the last week of life (Comfort Assessment in Dying–End-of-Life in Dementia-scale; primary outcome) and quality of care and dying in the last month of life (Quality of Dying in Long-Term Care scale; secondary outcome). Results: At baseline, we included 177 residents with advanced dementia, 126 with non-advanced dementia and 156 without dementia. Post-intervention, respectively in the control and the intervention group, we included 136 and 104 residents with advanced dementia, 167 and 110 with non-advanced dementia and 157 and 137 without dementia. We found no subgroup differences on comfort in the last week of life, comparing advanced versus without dementia (baseline-adjusted mean sub-group difference 2.1; p-value = 0.177), non-advanced versus without dementia (2.7; p = 0.092), and advanced versus non-advanced dementia (− 0.6; p = 0.698); or on quality of care and dying in the last month of life, comparing advanced and without dementia (− 0.6; p = 0.741), non-advanced and without dementia (− 1.5; p = 0.428), and advanced and non-advanced dementia (0.9; p = 0.632). Conclusions: The lack of subgroup difference suggests that while the program did not improve comfort in dying residents with or without dementia, it appeared to equally improve quality of care and dying in the last month of life for residents with dementia (regardless of the stage) and those without dementia. A generalist and non-disease-specific palliative care program, such as PACE Steps to Success, is a useful starting point for future palliative care improvement in nursing homes, but to effectively improve residents’ comfort, this program needs further development. Trial registration: ISRCTN, ISRCTN14741671. Registered 8 July 2015 – Retrospectively registered.

AB - Background: ‘PACE Steps to Success’ is a multicomponent training program aiming to integrate generalist and non-disease-specific palliative care in nursing homes. This program did not improve residents’ comfort in the last week of life, but it appeared to improve quality of care and dying in their last month of life. Because this program included only three dementia-specific elements, its effects might differ depending on the presence or stage of dementia. We aimed to investigate whether the program effects differ between residents with advanced, non-advanced, and no dementia. Methods: Pre-planned subgroup analysis of the PACE cluster-randomized controlled trial in 78 nursing homes in seven European countries. Participants included residents who died in the previous 4 months. The nursing home staff or general practitioner assessed the presence of dementia; severity was determined using two highly-discriminatory staff-reported instruments. Using after-death questionnaires, staff assessed comfort in the last week of life (Comfort Assessment in Dying–End-of-Life in Dementia-scale; primary outcome) and quality of care and dying in the last month of life (Quality of Dying in Long-Term Care scale; secondary outcome). Results: At baseline, we included 177 residents with advanced dementia, 126 with non-advanced dementia and 156 without dementia. Post-intervention, respectively in the control and the intervention group, we included 136 and 104 residents with advanced dementia, 167 and 110 with non-advanced dementia and 157 and 137 without dementia. We found no subgroup differences on comfort in the last week of life, comparing advanced versus without dementia (baseline-adjusted mean sub-group difference 2.1; p-value = 0.177), non-advanced versus without dementia (2.7; p = 0.092), and advanced versus non-advanced dementia (− 0.6; p = 0.698); or on quality of care and dying in the last month of life, comparing advanced and without dementia (− 0.6; p = 0.741), non-advanced and without dementia (− 1.5; p = 0.428), and advanced and non-advanced dementia (0.9; p = 0.632). Conclusions: The lack of subgroup difference suggests that while the program did not improve comfort in dying residents with or without dementia, it appeared to equally improve quality of care and dying in the last month of life for residents with dementia (regardless of the stage) and those without dementia. A generalist and non-disease-specific palliative care program, such as PACE Steps to Success, is a useful starting point for future palliative care improvement in nursing homes, but to effectively improve residents’ comfort, this program needs further development. Trial registration: ISRCTN, ISRCTN14741671. Registered 8 July 2015 – Retrospectively registered.

KW - Bereavement

KW - Communication

KW - End of life care

KW - Neurological conditions

KW - Nursing home care

KW - Pain

U2 - 10.1186/s12904-021-00734-1

DO - 10.1186/s12904-021-00734-1

M3 - Journal article

VL - 20

JO - BMC Palliative Care

JF - BMC Palliative Care

SN - 1472-684X

IS - 1

M1 - 39

ER -