Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systematic sclerosis.

Lancaster University

Keywords

Iontophoresis, Laser Doppler, Primary Raynaud's phenomenon, Systemic sclerosis, Scleroderma, Neuroendothelial control

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systematic sclerosis. / Anderson, M. E.; Hollis, S.; Moore, T. et al.
In: British Journal of Rheumatology, Vol. 35, No. 12, 1996, p. 1281-1288.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{183c3ee2643447e8aa45c0e6419608b8,

title = "Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systematic sclerosis.",

abstract = "We have non-invasively assessed neurovascular control mechanisms in forearm skin of 10 healthy control subjects, eight patients with primary Raynaud's phenomenon (PRP) and 10 patients with systemic sclerosis (SSc) by iontophoresing acetylcholine (endothelial dependent), sodium nitroprusside (endothelial independent) and adrenaline, and measuring subsequent blood flow responses by dual-channel laser Doppler. Because basal forearm blood flow is low, adrenaline response was assessed by attenuation of reperfusion hyperaemia following 60 s of upper arm occlusion. Reperfusion hyperaemia prior to adrenaline iontophoresis differed significantly between groups (F2.21, = 4.3, P = 0.03), being lowest in the SSc and highest in the PRP group. However, the degree of attenuation of this hyperaemia by adrenaline did not differ between groups and all groups demonstrated similar vasodilatory responses to acetylcholine and to sodium nitroprusside. These findings may reflect that abnormalities in vascular tone in patients with Raynaud's phenomenon are local to the digits, or that vasoactive agents not examined in this study play a key role.",

keywords = "Iontophoresis, Laser Doppler, Primary Raynaud's phenomenon, Systemic sclerosis, Scleroderma, Neuroendothelial control",

author = "Anderson, {M. E.} and S. Hollis and T. Moore and Jayson, {M. I. V.} and Herrick, {A. L.}",

year = "1996",

language = "English",

volume = "35",

pages = "1281--1288",

journal = "British Journal of Rheumatology",

publisher = "Oxford University Press",

number = "12",

}

RIS

TY - JOUR

T1 - Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systematic sclerosis.

AU - Anderson, M. E.

AU - Hollis, S.

AU - Moore, T.

AU - Jayson, M. I. V.

AU - Herrick, A. L.

PY - 1996

Y1 - 1996

N2 - We have non-invasively assessed neurovascular control mechanisms in forearm skin of 10 healthy control subjects, eight patients with primary Raynaud's phenomenon (PRP) and 10 patients with systemic sclerosis (SSc) by iontophoresing acetylcholine (endothelial dependent), sodium nitroprusside (endothelial independent) and adrenaline, and measuring subsequent blood flow responses by dual-channel laser Doppler. Because basal forearm blood flow is low, adrenaline response was assessed by attenuation of reperfusion hyperaemia following 60 s of upper arm occlusion. Reperfusion hyperaemia prior to adrenaline iontophoresis differed significantly between groups (F2.21, = 4.3, P = 0.03), being lowest in the SSc and highest in the PRP group. However, the degree of attenuation of this hyperaemia by adrenaline did not differ between groups and all groups demonstrated similar vasodilatory responses to acetylcholine and to sodium nitroprusside. These findings may reflect that abnormalities in vascular tone in patients with Raynaud's phenomenon are local to the digits, or that vasoactive agents not examined in this study play a key role.

AB - We have non-invasively assessed neurovascular control mechanisms in forearm skin of 10 healthy control subjects, eight patients with primary Raynaud's phenomenon (PRP) and 10 patients with systemic sclerosis (SSc) by iontophoresing acetylcholine (endothelial dependent), sodium nitroprusside (endothelial independent) and adrenaline, and measuring subsequent blood flow responses by dual-channel laser Doppler. Because basal forearm blood flow is low, adrenaline response was assessed by attenuation of reperfusion hyperaemia following 60 s of upper arm occlusion. Reperfusion hyperaemia prior to adrenaline iontophoresis differed significantly between groups (F2.21, = 4.3, P = 0.03), being lowest in the SSc and highest in the PRP group. However, the degree of attenuation of this hyperaemia by adrenaline did not differ between groups and all groups demonstrated similar vasodilatory responses to acetylcholine and to sodium nitroprusside. These findings may reflect that abnormalities in vascular tone in patients with Raynaud's phenomenon are local to the digits, or that vasoactive agents not examined in this study play a key role.

KW - Iontophoresis

KW - Laser Doppler

KW - Primary Raynaud's phenomenon

KW - Systemic sclerosis

KW - Scleroderma

KW - Neuroendothelial control

M3 - Journal article

VL - 35

SP - 1281

EP - 1288

JO - British Journal of Rheumatology

JF - British Journal of Rheumatology

IS - 12

ER -

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