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Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Lisa Liotta
  • Irene Medina
  • Jennifer Robinson
  • Chris Carroll
  • Po-Shen Pan
  • Ricardo Corral
  • Jennifer Johnston
  • Kristina Cook
  • Fiona Curtis
  • Gary Sharples
  • Shelli McAlpine
<mark>Journal publication date</mark>8/11/2004
<mark>Journal</mark>Tetrahedron Letters
Issue number46
Number of pages4
Pages (from-to)8447-8450
Publication StatusPublished
<mark>Original language</mark>English


Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.