Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Molecular Liquids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Molecular Liquids, 262, 2018 DOI: 10.1016/j.molliq.2019.03.119
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Novel aqueous biphasic system based on ethyl lactate for sustainable separations
T2 - Phase splitting mechanism
AU - Kamalanathan, Ishara
AU - Petrovski, Zeljko
AU - Branco, Luis C.
AU - Najdanovic-Visak, Vesna
N1 - This is the author’s version of a work that was accepted for publication in Journal of Molecular Liquids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Molecular Liquids, 262, 2018 DOI: 10.1016/j.molliq.2019.03.119
PY - 2018/7/15
Y1 - 2018/7/15
N2 - Ethyl lactate is a hydrophilic green solvent which is bio-renewable and biodegradable with low toxicity towards humans and animals. For the first time, we report that aqueous solutions of ethyl lactate separate into two aqueous phases upon addition of salts. The performance of trisodium citrate, disodium tartrate and disodium succinate as salting-out media for the separation of natural organic compounds, such as caffeine and catechin, from their aqueous solutions was examined. In this respect, cloud points for the ternary solutions composed of ethyl lactate, water and salt were determined at ambient pressure (0.1 MPa) at 298.2 K. Partition coefficients of caffeine and catechin between two phases were determined by chemical analysis of phases in equilibrium for different initial compositions at 298.2 K. The obtained results clearly demonstrate the ability of the ternary mixture to phase separate, providing good salting-out media for the efficient and sustainable separation from aqueous solution. 1H NMR spectroscopy was employed to elucidate the mechanisms of phase splitting in the ternary (ethyl lactate + water + salt) systems at molecular level. The discovery of aqueous biphasic system (ABS) containing ethyl lactate as hydrophilic solvent opens a new and green platform for extraction of various compounds from aqueous solutions.
AB - Ethyl lactate is a hydrophilic green solvent which is bio-renewable and biodegradable with low toxicity towards humans and animals. For the first time, we report that aqueous solutions of ethyl lactate separate into two aqueous phases upon addition of salts. The performance of trisodium citrate, disodium tartrate and disodium succinate as salting-out media for the separation of natural organic compounds, such as caffeine and catechin, from their aqueous solutions was examined. In this respect, cloud points for the ternary solutions composed of ethyl lactate, water and salt were determined at ambient pressure (0.1 MPa) at 298.2 K. Partition coefficients of caffeine and catechin between two phases were determined by chemical analysis of phases in equilibrium for different initial compositions at 298.2 K. The obtained results clearly demonstrate the ability of the ternary mixture to phase separate, providing good salting-out media for the efficient and sustainable separation from aqueous solution. 1H NMR spectroscopy was employed to elucidate the mechanisms of phase splitting in the ternary (ethyl lactate + water + salt) systems at molecular level. The discovery of aqueous biphasic system (ABS) containing ethyl lactate as hydrophilic solvent opens a new and green platform for extraction of various compounds from aqueous solutions.
KW - Aqueous two-phase system
KW - Green extraction
KW - Natural organic compounds
U2 - 10.1016/j.molliq.2018.03.119
DO - 10.1016/j.molliq.2018.03.119
M3 - Journal article
VL - 262
SP - 37
EP - 45
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
ER -