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Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission

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Novel cytomegaloviruses in free-ranging and captive great apes : phylogenetic evidence for bidirectional horizontal transmission. / Leendertz, Fabian H.; Deckers, Merlin; Schempp, Werner et al.

In: Journal of General Virology, Vol. 90, No. 10, 10.2009, p. 2386-2394.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Leendertz, FH, Deckers, M, Schempp, W, Lankester, F, Boesch, C, Mugisha, L, Dolan, A, Gatherer, D, McGeoch, DJ & Ehlers, B 2009, 'Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission', Journal of General Virology, vol. 90, no. 10, pp. 2386-2394. https://doi.org/10.1099/vir.0.011866-0

APA

Leendertz, F. H., Deckers, M., Schempp, W., Lankester, F., Boesch, C., Mugisha, L., Dolan, A., Gatherer, D., McGeoch, D. J., & Ehlers, B. (2009). Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission. Journal of General Virology, 90(10), 2386-2394. https://doi.org/10.1099/vir.0.011866-0

Vancouver

Leendertz FH, Deckers M, Schempp W, Lankester F, Boesch C, Mugisha L et al. Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission. Journal of General Virology. 2009 Oct;90(10):2386-2394. doi: 10.1099/vir.0.011866-0

Author

Leendertz, Fabian H. ; Deckers, Merlin ; Schempp, Werner et al. / Novel cytomegaloviruses in free-ranging and captive great apes : phylogenetic evidence for bidirectional horizontal transmission. In: Journal of General Virology. 2009 ; Vol. 90, No. 10. pp. 2386-2394.

Bibtex

@article{42d58d36591849588cd07a827ab36c0b,
title = "Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission",
abstract = "Wild great apes often suffer from diseases of unknown aetiology. This is among the causes of population declines. Because human cytomegalovirus (HCMV) is an important pathogen, especially in immunocompromised individuals, a search for cytomegaloviruses (CMVs) in deceased wild and captive chimpanzees, gorillas and orang-utans was performed. By using a degenerate PCR targeting four conserved genes (UL54-UL57), several distinct, previously unrecognized CMVs were found for each species. Sequences of up to 9 kb were determined for ten novel CMVs, located in the UL54-UL57 block. A phylogenetic tree was inferred for the ten novel CMVs, the previously characterized chimpanzee CMV, HCMV strains and Old World and New World monkey CMVs. The primate CMVs fell into four clades, containing New World monkey, Old World monkey, orang-utan and human CMVs, respectively, plus two clades that each contained both chimpanzee and gorilla isolates (termed CG1 and CG2). The tree loci of the first four clades mirrored those for their respective hosts in the primate tree, suggesting that these CMV lineages arose through cospeciation with host lineages. The CG1 and CG2 loci corresponded to those of the gorilla and chimpanzee hosts, respectively. This was interpreted as indicating that CG1 and CG2 represented CMV lineages that had arisen cospeciationally with the gorilla and chimpanzee lineages, respectively, with subsequent transfer within each clade between the host genera. Divergence dates were estimated and found to be consistent with overall cospeciational development of major primate CMV lineages. However, CMV transmission between chimpanzees and gorillas in both directions has also occurred.",
keywords = "Amino Acid Sequence, Animals, Animals, Zoo, Ape Diseases, Base Sequence, Cytomegalovirus, Cytomegalovirus Infections, Gene Expression Regulation, Viral, Gorilla gorilla, Humans, Pan troglodytes, Phylogeny, Pongo pygmaeus, Viral Proteins",
author = "Leendertz, {Fabian H.} and Merlin Deckers and Werner Schempp and Felix Lankester and Christophe Boesch and Lawrence Mugisha and Aidan Dolan and Derek Gatherer and McGeoch, {Duncan J.} and Bernhard Ehlers",
year = "2009",
month = oct,
doi = "10.1099/vir.0.011866-0",
language = "English",
volume = "90",
pages = "2386--2394",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",
number = "10",

}

RIS

TY - JOUR

T1 - Novel cytomegaloviruses in free-ranging and captive great apes

T2 - phylogenetic evidence for bidirectional horizontal transmission

AU - Leendertz, Fabian H.

AU - Deckers, Merlin

AU - Schempp, Werner

AU - Lankester, Felix

AU - Boesch, Christophe

AU - Mugisha, Lawrence

AU - Dolan, Aidan

AU - Gatherer, Derek

AU - McGeoch, Duncan J.

AU - Ehlers, Bernhard

PY - 2009/10

Y1 - 2009/10

N2 - Wild great apes often suffer from diseases of unknown aetiology. This is among the causes of population declines. Because human cytomegalovirus (HCMV) is an important pathogen, especially in immunocompromised individuals, a search for cytomegaloviruses (CMVs) in deceased wild and captive chimpanzees, gorillas and orang-utans was performed. By using a degenerate PCR targeting four conserved genes (UL54-UL57), several distinct, previously unrecognized CMVs were found for each species. Sequences of up to 9 kb were determined for ten novel CMVs, located in the UL54-UL57 block. A phylogenetic tree was inferred for the ten novel CMVs, the previously characterized chimpanzee CMV, HCMV strains and Old World and New World monkey CMVs. The primate CMVs fell into four clades, containing New World monkey, Old World monkey, orang-utan and human CMVs, respectively, plus two clades that each contained both chimpanzee and gorilla isolates (termed CG1 and CG2). The tree loci of the first four clades mirrored those for their respective hosts in the primate tree, suggesting that these CMV lineages arose through cospeciation with host lineages. The CG1 and CG2 loci corresponded to those of the gorilla and chimpanzee hosts, respectively. This was interpreted as indicating that CG1 and CG2 represented CMV lineages that had arisen cospeciationally with the gorilla and chimpanzee lineages, respectively, with subsequent transfer within each clade between the host genera. Divergence dates were estimated and found to be consistent with overall cospeciational development of major primate CMV lineages. However, CMV transmission between chimpanzees and gorillas in both directions has also occurred.

AB - Wild great apes often suffer from diseases of unknown aetiology. This is among the causes of population declines. Because human cytomegalovirus (HCMV) is an important pathogen, especially in immunocompromised individuals, a search for cytomegaloviruses (CMVs) in deceased wild and captive chimpanzees, gorillas and orang-utans was performed. By using a degenerate PCR targeting four conserved genes (UL54-UL57), several distinct, previously unrecognized CMVs were found for each species. Sequences of up to 9 kb were determined for ten novel CMVs, located in the UL54-UL57 block. A phylogenetic tree was inferred for the ten novel CMVs, the previously characterized chimpanzee CMV, HCMV strains and Old World and New World monkey CMVs. The primate CMVs fell into four clades, containing New World monkey, Old World monkey, orang-utan and human CMVs, respectively, plus two clades that each contained both chimpanzee and gorilla isolates (termed CG1 and CG2). The tree loci of the first four clades mirrored those for their respective hosts in the primate tree, suggesting that these CMV lineages arose through cospeciation with host lineages. The CG1 and CG2 loci corresponded to those of the gorilla and chimpanzee hosts, respectively. This was interpreted as indicating that CG1 and CG2 represented CMV lineages that had arisen cospeciationally with the gorilla and chimpanzee lineages, respectively, with subsequent transfer within each clade between the host genera. Divergence dates were estimated and found to be consistent with overall cospeciational development of major primate CMV lineages. However, CMV transmission between chimpanzees and gorillas in both directions has also occurred.

KW - Amino Acid Sequence

KW - Animals

KW - Animals, Zoo

KW - Ape Diseases

KW - Base Sequence

KW - Cytomegalovirus

KW - Cytomegalovirus Infections

KW - Gene Expression Regulation, Viral

KW - Gorilla gorilla

KW - Humans

KW - Pan troglodytes

KW - Phylogeny

KW - Pongo pygmaeus

KW - Viral Proteins

U2 - 10.1099/vir.0.011866-0

DO - 10.1099/vir.0.011866-0

M3 - Journal article

C2 - 19553394

VL - 90

SP - 2386

EP - 2394

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

IS - 10

ER -