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Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

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Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. / Hamilton, A.; Patterson, S.; Porter, David; Gault, Victor A.; Hölscher, Christian.

In: Journal of Neuroscience Research, Vol. 89, No. 4, 04.2011, p. 481-489.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hamilton, A, Patterson, S, Porter, D, Gault, VA & Hölscher, C 2011, 'Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain', Journal of Neuroscience Research, vol. 89, no. 4, pp. 481-489. https://doi.org/10.1002/jnr.22565

APA

Hamilton, A., Patterson, S., Porter, D., Gault, V. A., & Hölscher, C. (2011). Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. Journal of Neuroscience Research, 89(4), 481-489. https://doi.org/10.1002/jnr.22565

Vancouver

Hamilton A, Patterson S, Porter D, Gault VA, Hölscher C. Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. Journal of Neuroscience Research. 2011 Apr;89(4):481-489. https://doi.org/10.1002/jnr.22565

Author

Hamilton, A. ; Patterson, S. ; Porter, David ; Gault, Victor A. ; Hölscher, Christian. / Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. In: Journal of Neuroscience Research. 2011 ; Vol. 89, No. 4. pp. 481-489.

Bibtex

@article{87d4e16fb74c425aa92b5492299a9935,
title = "Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain",
abstract = "One of the symptoms of diabetes is the progressive development of neuropathies. One mechanism to replace neurons in the CNS is through the activation of stem cells and neuronal progenitor cells. We have tested the effects of the novel GLP-1 mimetics exenatide (exendin-4; Byetta) and liraglutide (NN2211; Victoza), which are already on the market as treatments for type 2 diabetes, on the proliferation rate of progenitor cells and differentiation into neurons in the dentate gyrus of brains of mouse models of diabetes. GLP-1 analogues were injected subcutaneously for 4, 6, or 10 weeks once daily in three mouse models of diabetes: ob/ob mice, db/db mice, or high-fat-diet-fed mice. Twenty-four hours before perfusion, animals were injected with 5'-bromo-2'-deoxyuridine (BrdU) to mark dividing progenitor cells. By using immunohistochemistry and stereological methods, the number of progenitor cells or doublecortin-positive young neurons in the dentate gyrus was estimated. We found that, in all three mouse models, progenitor cell division was enhanced compared with nondiabetic controls after chronic i.p. injection of either liraglutide or exendin-4 by 100-150% (P ",
keywords = "Animals, Brain, Cell Differentiation, Cell Proliferation, Dentate Gyrus, Diabetes Mellitus, Type 2, Disease Models, Animal, Glucagon-Like Peptide 1, Hypoglycemic Agents, Immunohistochemistry, Male, Mice, Neural Stem Cells, Neurogenesis, Neurons, Peptides, Venoms",
author = "A. Hamilton and S. Patterson and David Porter and Gault, {Victor A.} and Christian H{\"o}lscher",
note = "Copyright {\textcopyright} 2011 Wiley-Liss, Inc.",
year = "2011",
month = apr,
doi = "10.1002/jnr.22565",
language = "English",
volume = "89",
pages = "481--489",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

AU - Hamilton, A.

AU - Patterson, S.

AU - Porter, David

AU - Gault, Victor A.

AU - Hölscher, Christian

N1 - Copyright © 2011 Wiley-Liss, Inc.

PY - 2011/4

Y1 - 2011/4

N2 - One of the symptoms of diabetes is the progressive development of neuropathies. One mechanism to replace neurons in the CNS is through the activation of stem cells and neuronal progenitor cells. We have tested the effects of the novel GLP-1 mimetics exenatide (exendin-4; Byetta) and liraglutide (NN2211; Victoza), which are already on the market as treatments for type 2 diabetes, on the proliferation rate of progenitor cells and differentiation into neurons in the dentate gyrus of brains of mouse models of diabetes. GLP-1 analogues were injected subcutaneously for 4, 6, or 10 weeks once daily in three mouse models of diabetes: ob/ob mice, db/db mice, or high-fat-diet-fed mice. Twenty-four hours before perfusion, animals were injected with 5'-bromo-2'-deoxyuridine (BrdU) to mark dividing progenitor cells. By using immunohistochemistry and stereological methods, the number of progenitor cells or doublecortin-positive young neurons in the dentate gyrus was estimated. We found that, in all three mouse models, progenitor cell division was enhanced compared with nondiabetic controls after chronic i.p. injection of either liraglutide or exendin-4 by 100-150% (P

AB - One of the symptoms of diabetes is the progressive development of neuropathies. One mechanism to replace neurons in the CNS is through the activation of stem cells and neuronal progenitor cells. We have tested the effects of the novel GLP-1 mimetics exenatide (exendin-4; Byetta) and liraglutide (NN2211; Victoza), which are already on the market as treatments for type 2 diabetes, on the proliferation rate of progenitor cells and differentiation into neurons in the dentate gyrus of brains of mouse models of diabetes. GLP-1 analogues were injected subcutaneously for 4, 6, or 10 weeks once daily in three mouse models of diabetes: ob/ob mice, db/db mice, or high-fat-diet-fed mice. Twenty-four hours before perfusion, animals were injected with 5'-bromo-2'-deoxyuridine (BrdU) to mark dividing progenitor cells. By using immunohistochemistry and stereological methods, the number of progenitor cells or doublecortin-positive young neurons in the dentate gyrus was estimated. We found that, in all three mouse models, progenitor cell division was enhanced compared with nondiabetic controls after chronic i.p. injection of either liraglutide or exendin-4 by 100-150% (P

KW - Animals

KW - Brain

KW - Cell Differentiation

KW - Cell Proliferation

KW - Dentate Gyrus

KW - Diabetes Mellitus, Type 2

KW - Disease Models, Animal

KW - Glucagon-Like Peptide 1

KW - Hypoglycemic Agents

KW - Immunohistochemistry

KW - Male

KW - Mice

KW - Neural Stem Cells

KW - Neurogenesis

KW - Neurons

KW - Peptides

KW - Venoms

U2 - 10.1002/jnr.22565

DO - 10.1002/jnr.22565

M3 - Journal article

C2 - 21312223

VL - 89

SP - 481

EP - 489

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 4

ER -