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Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation

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Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation. / Yusuf, Hayat Abdulla; Baldock, Sara J.; Barber, Robert W. et al.

In: Microelectronic Engineering, Vol. 85, No. 5-6, 05.2008, p. 1265-1268.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Yusuf HA, Baldock SJ, Barber RW, Fielden PR, Goddard NJ, Brown BJT. Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation. Microelectronic Engineering. 2008 May;85(5-6):1265-1268. doi: 10.1016/j.mee.2007.12.052

Author

Yusuf, Hayat Abdulla ; Baldock, Sara J. ; Barber, Robert W. et al. / Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation. In: Microelectronic Engineering. 2008 ; Vol. 85, No. 5-6. pp. 1265-1268.

Bibtex

@article{441234ef7ec145049cbf2c58c784c9ea,
title = "Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation",
abstract = "Novel microfluidic resistive network designs have been evaluated theoretically and experimentally. Such networks are an important component of microreactor technology and are used in analytical and biomedical applications for precisely controlled and evenly stepped dilution.A detailed model and a simplification algorithm have been devised for these networks. Their combination produces novel simplified network designs that exhibit less hierarchical branching over existing network designs. Rapid prediction and optimization of a layout that meets an arbitrary outlet profile is also possible.High levels of linearity were achieved on three microdevice fluidic networks. Good agreement of the experimental results from tested devices with the model was obtained. In addition, CFD simulation of one of the designs gave good agreement with results from the model presented, a good linear outlet profile being obtained.",
keywords = "Microfluidics, Microfabrication, Concentration gradient, Microreactor technology",
author = "Yusuf, {Hayat Abdulla} and Baldock, {Sara J.} and Barber, {Robert W.} and Fielden, {Peter R.} and Goddard, {Nick J.} and Brown, {Bernard J. Treves}",
year = "2008",
month = may,
doi = "10.1016/j.mee.2007.12.052",
language = "English",
volume = "85",
pages = "1265--1268",
journal = "Microelectronic Engineering",
issn = "0167-9317",
publisher = "Elsevier",
number = "5-6",

}

RIS

TY - JOUR

T1 - Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation

AU - Yusuf, Hayat Abdulla

AU - Baldock, Sara J.

AU - Barber, Robert W.

AU - Fielden, Peter R.

AU - Goddard, Nick J.

AU - Brown, Bernard J. Treves

PY - 2008/5

Y1 - 2008/5

N2 - Novel microfluidic resistive network designs have been evaluated theoretically and experimentally. Such networks are an important component of microreactor technology and are used in analytical and biomedical applications for precisely controlled and evenly stepped dilution.A detailed model and a simplification algorithm have been devised for these networks. Their combination produces novel simplified network designs that exhibit less hierarchical branching over existing network designs. Rapid prediction and optimization of a layout that meets an arbitrary outlet profile is also possible.High levels of linearity were achieved on three microdevice fluidic networks. Good agreement of the experimental results from tested devices with the model was obtained. In addition, CFD simulation of one of the designs gave good agreement with results from the model presented, a good linear outlet profile being obtained.

AB - Novel microfluidic resistive network designs have been evaluated theoretically and experimentally. Such networks are an important component of microreactor technology and are used in analytical and biomedical applications for precisely controlled and evenly stepped dilution.A detailed model and a simplification algorithm have been devised for these networks. Their combination produces novel simplified network designs that exhibit less hierarchical branching over existing network designs. Rapid prediction and optimization of a layout that meets an arbitrary outlet profile is also possible.High levels of linearity were achieved on three microdevice fluidic networks. Good agreement of the experimental results from tested devices with the model was obtained. In addition, CFD simulation of one of the designs gave good agreement with results from the model presented, a good linear outlet profile being obtained.

KW - Microfluidics

KW - Microfabrication

KW - Concentration gradient

KW - Microreactor technology

U2 - 10.1016/j.mee.2007.12.052

DO - 10.1016/j.mee.2007.12.052

M3 - Journal article

VL - 85

SP - 1265

EP - 1268

JO - Microelectronic Engineering

JF - Microelectronic Engineering

SN - 0167-9317

IS - 5-6

ER -