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Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Suzanne J. Dilly
  • Matthew P. Beecham
  • Steven P. Brown
  • John M. Griffin
  • Andrew J. Clark
  • Craig D. Griffin
  • Jacqueline Marshall
  • Richard M. Napier
  • Paul C. Taylor
  • Andrew Marsh
<mark>Journal publication date</mark>12/09/2006
Issue number19
Number of pages7
Pages (from-to)8144-8150
Publication StatusPublished
Early online date9/08/06
<mark>Original language</mark>English


Novel surfaces derivatized with tertiary amine oxides have been prepared and tested for their ability to resist nonspecific protein adsorption. The oxidation of tertiary amines supported on triazine units was carried out using mCPBA to give a format allowing conjugation of biologically active ligands alongside them. Adsorption to these surfaces was tested and compared to adsorption to a set of commercial and custom oligo-/poly(ethylene glycol) (OEG/PEG) supports by challenging them with a protein display library presented on bacteriophage I. The new class of amine oxide surfaces is found to compare favorably with the performance of the OEG/PEG supports in the prevention of nonspecific binding.