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  • MLBLUE-D-19-04331R1

    Rights statement: This is the author’s version of a work that was accepted for publication in Materials Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Letters, 261, 2020 DOI: 10.1016/j.matlet.2019.127115

    Accepted author manuscript, 1.76 MB, PDF document

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses

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Article number127115
<mark>Journal publication date</mark>15/02/2020
<mark>Journal</mark>Materials Letters
Volume261
Number of pages5
Publication StatusPublished
<mark>Original language</mark>English

Abstract

In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Materials Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Letters, 261, 2020 DOI: 10.1016/j.matlet.2019.127115