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Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model?

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model? / Gibson, Lorna M.; Allan, Stuart M.; Parkes, Laura M. et al.
In: Cardiovascular Psychiatry and Neurology, Vol. 2011, 130406, 2011.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gibson, LM, Allan, SM, Parkes, LM & Emsley, HCA 2011, 'Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model?', Cardiovascular Psychiatry and Neurology, vol. 2011, 130406. https://doi.org/10.1155/2011/130406

APA

Gibson, L. M., Allan, S. M., Parkes, L. M., & Emsley, H. C. A. (2011). Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model? Cardiovascular Psychiatry and Neurology, 2011, Article 130406. https://doi.org/10.1155/2011/130406

Vancouver

Gibson LM, Allan SM, Parkes LM, Emsley HCA. Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model? Cardiovascular Psychiatry and Neurology. 2011;2011:130406. doi: 10.1155/2011/130406

Author

Gibson, Lorna M. ; Allan, Stuart M. ; Parkes, Laura M. et al. / Occult cerebrovascular disease and late-onset epilepsy : could loss of neurovascular unit integrity be a viable model?. In: Cardiovascular Psychiatry and Neurology. 2011 ; Vol. 2011.

Bibtex

@article{46afc3947b284387914110a73c08f353,
title = "Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model?",
abstract = "Late-onset epilepsy (LOE) first occurs after 60 years of age and may be due to occult cerebrovascular disease (CVD) which confers an increased risk of stroke. However, patients with late-onset epilepsy are not currently consistently investigated or treated for cerebrovascular risk factors. We discuss how abnormalities of neurovascular unit function, namely, changes in regional cerebral blood flow and blood brain barrier disruption, may be caused by occult cerebrovascular disease but present clinically as late-onset epilepsy. We describe novel magnetic resonance imaging methods to detect abnormal neurovascular unit function in subjects with LOE and controls. We hypothesise that occult CVD may cause LOE as a result of neurovascular unit dysfunction.",
author = "Gibson, {Lorna M.} and Allan, {Stuart M.} and Parkes, {Laura M.} and Emsley, {Hedley C. A.}",
year = "2011",
doi = "10.1155/2011/130406",
language = "English",
volume = "2011",
journal = "Cardiovascular Psychiatry and Neurology",
issn = "2090-0163",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Occult cerebrovascular disease and late-onset epilepsy

T2 - could loss of neurovascular unit integrity be a viable model?

AU - Gibson, Lorna M.

AU - Allan, Stuart M.

AU - Parkes, Laura M.

AU - Emsley, Hedley C. A.

PY - 2011

Y1 - 2011

N2 - Late-onset epilepsy (LOE) first occurs after 60 years of age and may be due to occult cerebrovascular disease (CVD) which confers an increased risk of stroke. However, patients with late-onset epilepsy are not currently consistently investigated or treated for cerebrovascular risk factors. We discuss how abnormalities of neurovascular unit function, namely, changes in regional cerebral blood flow and blood brain barrier disruption, may be caused by occult cerebrovascular disease but present clinically as late-onset epilepsy. We describe novel magnetic resonance imaging methods to detect abnormal neurovascular unit function in subjects with LOE and controls. We hypothesise that occult CVD may cause LOE as a result of neurovascular unit dysfunction.

AB - Late-onset epilepsy (LOE) first occurs after 60 years of age and may be due to occult cerebrovascular disease (CVD) which confers an increased risk of stroke. However, patients with late-onset epilepsy are not currently consistently investigated or treated for cerebrovascular risk factors. We discuss how abnormalities of neurovascular unit function, namely, changes in regional cerebral blood flow and blood brain barrier disruption, may be caused by occult cerebrovascular disease but present clinically as late-onset epilepsy. We describe novel magnetic resonance imaging methods to detect abnormal neurovascular unit function in subjects with LOE and controls. We hypothesise that occult CVD may cause LOE as a result of neurovascular unit dysfunction.

U2 - 10.1155/2011/130406

DO - 10.1155/2011/130406

M3 - Journal article

AN - SCOPUS:79955052799

VL - 2011

JO - Cardiovascular Psychiatry and Neurology

JF - Cardiovascular Psychiatry and Neurology

SN - 2090-0163

M1 - 130406

ER -