Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - On the origin of influenza A hemagglutinin
AU - Gatherer, Derek
PY - 2009/12
Y1 - 2009/12
N2 - Recent advances in phylogenetic methods have produced some reassessments of the ages of the most recent common ancestor of hemagglutinin proteins in known strains of influenza A. This paper applies Bayesian phylogenetic analysis implemented in BEAST to date the nodes on the influenza A hemagglutinin tree. The most recent common ancestor (MRCA) of influenza A hemagglutinin proteins is located with 95% confidence between 517 and 1497 of the Common Era (AD), with the center of the probability distribution at 1056 AD. The implications of this revised dating for both historical and current epidemiology are discussed. Influenza A can be seen as an emerging disease of mediaeval and early modern times.
AB - Recent advances in phylogenetic methods have produced some reassessments of the ages of the most recent common ancestor of hemagglutinin proteins in known strains of influenza A. This paper applies Bayesian phylogenetic analysis implemented in BEAST to date the nodes on the influenza A hemagglutinin tree. The most recent common ancestor (MRCA) of influenza A hemagglutinin proteins is located with 95% confidence between 517 and 1497 of the Common Era (AD), with the center of the probability distribution at 1056 AD. The implications of this revised dating for both historical and current epidemiology are discussed. Influenza A can be seen as an emerging disease of mediaeval and early modern times.
KW - Influenza A
KW - Hemagglutinin
KW - H1N1
KW - ENGLISH SWEATING SICKNESS
KW - 1918 FLU VIRUS
KW - EVOLUTION
KW - DISEASE
KW - MODEL
KW - EMERGENCE
KW - OUTBREAK
KW - GENES
U2 - 10.1007/s12088-009-0062-5
DO - 10.1007/s12088-009-0062-5
M3 - Journal article
VL - 49
SP - 352
EP - 357
JO - Indian Journal of Microbiology
JF - Indian Journal of Microbiology
SN - 0046-8991
IS - 4
ER -