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Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells

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Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells. / Zhang, Pingyu; Chiu, Cookson K. C.; Huang, Huaiyi et al.
In: Angewandte Chemie, Vol. 129, No. 47, 20.11.2017, p. 15094-15098.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Zhang, P, Chiu, CKC, Huang, H, Lam, YPY, Habtemariam, A, Malcomson, T, Paterson, MJ, Clarkson, GJ, O'Connor, PB, Chao, H & Sadler, PJ 2017, 'Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells', Angewandte Chemie, vol. 129, no. 47, pp. 15094-15098. https://doi.org/10.1002/ange.201709082

APA

Zhang, P., Chiu, C. K. C., Huang, H., Lam, Y. P. Y., Habtemariam, A., Malcomson, T., Paterson, M. J., Clarkson, G. J., O'Connor, P. B., Chao, H., & Sadler, P. J. (2017). Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells. Angewandte Chemie, 129(47), 15094-15098. https://doi.org/10.1002/ange.201709082

Vancouver

Zhang P, Chiu CKC, Huang H, Lam YPY, Habtemariam A, Malcomson T et al. Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells. Angewandte Chemie. 2017 Nov 20;129(47):15094-15098. Epub 2017 Oct 19. doi: 10.1002/ange.201709082

Author

Zhang, Pingyu ; Chiu, Cookson K. C. ; Huang, Huaiyi et al. / Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells. In: Angewandte Chemie. 2017 ; Vol. 129, No. 47. pp. 15094-15098.

Bibtex

@article{05e66581b95e4aa2a31a9f725d537d4d,
title = "Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells",
abstract = "Strongly luminescent iridium(III) complexes, [Ir(C,N)2(S ,S )]+ (1 ) and [Ir(C,N)2(O,O)] (2 ), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X‐ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of 1O2, with large 2‐photon absorption cross‐sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub‐micromolar doses towards 3D multicellular tumor spheroids with 2‐photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat‐shock protein‐70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase the levels of enzymes involved in the glycolytic pathway.",
author = "Pingyu Zhang and Chiu, {Cookson K. C.} and Huaiyi Huang and Lam, {Yuko P. Y.} and Abraha Habtemariam and Thomas Malcomson and Paterson, {Martin J.} and Clarkson, {Guy J.} and O'Connor, {Peter B.} and Hui Chao and Sadler, {Peter J.}",
year = "2017",
month = nov,
day = "20",
doi = "10.1002/ange.201709082",
language = "English",
volume = "129",
pages = "15094--15098",
journal = "Angewandte Chemie",
issn = "0044-8249",
publisher = "John Wiley & Sons, Ltd",
number = "47",

}

RIS

TY - JOUR

T1 - Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells

AU - Zhang, Pingyu

AU - Chiu, Cookson K. C.

AU - Huang, Huaiyi

AU - Lam, Yuko P. Y.

AU - Habtemariam, Abraha

AU - Malcomson, Thomas

AU - Paterson, Martin J.

AU - Clarkson, Guy J.

AU - O'Connor, Peter B.

AU - Chao, Hui

AU - Sadler, Peter J.

PY - 2017/11/20

Y1 - 2017/11/20

N2 - Strongly luminescent iridium(III) complexes, [Ir(C,N)2(S ,S )]+ (1 ) and [Ir(C,N)2(O,O)] (2 ), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X‐ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of 1O2, with large 2‐photon absorption cross‐sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub‐micromolar doses towards 3D multicellular tumor spheroids with 2‐photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat‐shock protein‐70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase the levels of enzymes involved in the glycolytic pathway.

AB - Strongly luminescent iridium(III) complexes, [Ir(C,N)2(S ,S )]+ (1 ) and [Ir(C,N)2(O,O)] (2 ), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X‐ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of 1O2, with large 2‐photon absorption cross‐sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub‐micromolar doses towards 3D multicellular tumor spheroids with 2‐photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat‐shock protein‐70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase the levels of enzymes involved in the glycolytic pathway.

U2 - 10.1002/ange.201709082

DO - 10.1002/ange.201709082

M3 - Journal article

VL - 129

SP - 15094

EP - 15098

JO - Angewandte Chemie

JF - Angewandte Chemie

SN - 0044-8249

IS - 47

ER -