Research output: Contribution to Journal/Magazine › Journal article › peer-review
<mark>Journal publication date</mark> | 3/10/2008 |
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<mark>Journal</mark> | Journal of Organic Chemistry |
Issue number | 19 |
Volume | 73 |
Number of pages | 4 |
Pages (from-to) | 7852-7855 |
Publication Status | Published |
<mark>Original language</mark> | English |
In 18 out of 20 examples of the organolithium-mediated conversion of beta-alkoxy aziridines into substituted allylic sulfonamides, use of a Bus (Bus = t-BuSO(2)) substituent on the nitrogen gave higher yields compared to the analogous N-Ts compounds. The success with the N-Bus aziridines facilitated the development of a new route to the spirocyclic core of the histrionicotoxins and completion of a formal synthesis of (+/-)-perhydrohistrionicotoxin.