TY - JOUR

T1 - Origins of DNA replication in the three domains of life

AU - Robinson, Nicholas P.

AU - Bell, Stephen D.

PY - 2005/8

Y1 - 2005/8

N2 - Replication of DNA is essential for the propagation of life. It is somewhat surprising then that, despite the vital nature of this process, cellular organisms show a great deal of variety in the mechanisms that they employ to ensure appropriate genome duplication. This diversity is manifested along classical evolutionary lines, with distinct combinations of replicon architecture and replication proteins being found in the three domains of life: the Bacteria, the Eukarya and the Archaea. Furthermore, although there are mechanistic parallels, even within a given domain of life, the way origins of replication are defined shows remarkable variation.

AB - Replication of DNA is essential for the propagation of life. It is somewhat surprising then that, despite the vital nature of this process, cellular organisms show a great deal of variety in the mechanisms that they employ to ensure appropriate genome duplication. This diversity is manifested along classical evolutionary lines, with distinct combinations of replicon architecture and replication proteins being found in the three domains of life: the Bacteria, the Eukarya and the Archaea. Furthermore, although there are mechanistic parallels, even within a given domain of life, the way origins of replication are defined shows remarkable variation.

KW - Archaea

KW - Bacteria

KW - DNA Replication

KW - Eukaryotic Cells

KW - Evolution, Molecular

KW - Replication Origin

KW - Saccharomyces cerevisiae

KW - Schizosaccharomyces

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1111/j.1742-4658.2005.04768.x

DO - 10.1111/j.1742-4658.2005.04768.x

M3 - Journal article

C2 - 16045748

VL - 272

SP - 3757

EP - 3766

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 15

ER -