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  • Franckevicius Org Lett Manuscript 2021

    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.1c04075

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Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides

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Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides. / Laidlaw, Gillian; Franckevicius, Vilius.
In: Organic Letters, Vol. 24, No. 1, 14.01.2022, p. 400-405.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Laidlaw G, Franckevicius V. Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides. Organic Letters. 2022 Jan 14;24(1):400-405. Epub 2021 Dec 16. doi: 10.1021/acs.orglett.1c04075

Author

Laidlaw, Gillian ; Franckevicius, Vilius. / Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides. In: Organic Letters. 2022 ; Vol. 24, No. 1. pp. 400-405.

Bibtex

@article{8e57ce6e7fd14d32bb02c7ff110faf08,
title = "Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides",
abstract = "A palladium-catalyzed decarboxylative asymmetric allylic alkylation of thietane 1,1-dioxides via linear enolate intermediates from racemic starting materials has been developed. This process installs an α-sulfonyl tetrasubstituted stereogenic center with high enantioselectivity. The potential to transform the alkylated products to novel types of enantioenriched spirocycles for medicinal chemistry applications has also been demonstrated.",
author = "Gillian Laidlaw and Vilius Franckevicius",
note = "This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright {\textcopyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.1c04075",
year = "2022",
month = jan,
day = "14",
doi = "10.1021/acs.orglett.1c04075",
language = "English",
volume = "24",
pages = "400--405",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "1",

}

RIS

TY - JOUR

T1 - Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides

AU - Laidlaw, Gillian

AU - Franckevicius, Vilius

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.1c04075

PY - 2022/1/14

Y1 - 2022/1/14

N2 - A palladium-catalyzed decarboxylative asymmetric allylic alkylation of thietane 1,1-dioxides via linear enolate intermediates from racemic starting materials has been developed. This process installs an α-sulfonyl tetrasubstituted stereogenic center with high enantioselectivity. The potential to transform the alkylated products to novel types of enantioenriched spirocycles for medicinal chemistry applications has also been demonstrated.

AB - A palladium-catalyzed decarboxylative asymmetric allylic alkylation of thietane 1,1-dioxides via linear enolate intermediates from racemic starting materials has been developed. This process installs an α-sulfonyl tetrasubstituted stereogenic center with high enantioselectivity. The potential to transform the alkylated products to novel types of enantioenriched spirocycles for medicinal chemistry applications has also been demonstrated.

U2 - 10.1021/acs.orglett.1c04075

DO - 10.1021/acs.orglett.1c04075

M3 - Journal article

VL - 24

SP - 400

EP - 405

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 1

ER -