Home > Research > Publications & Outputs > Patterns of adverse childhood experiences and a...

Research

Electronic data

Links

Text available via DOI:

Keywords

View graph of relations

Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. / Hemady, Chad Lance; Speyer, Lydia Gabriela; Murray, Aja Louise et al.
In: BMC Pregnancy and Childbirth, Vol. 22, No. 1, 505, 22.06.2022, p. 505.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hemady, CL, Speyer, LG, Murray, AL, Brown, RH, Meinck, F, Fry, D, Do, H, Sikander, S, Madrid, B, Fernando, A, Walker, S, Dunne, M, Foley, S, Hughes, C, Osafo, J, Baban, A, Taut, D, Ward, CL, Van Thang, V, Fearon, P, Tomlinson, M, Valdebenito, S & Eisner, M 2022, 'Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis', BMC Pregnancy and Childbirth, vol. 22, no. 1, 505, pp. 505. https://doi.org/10.1186/s12884-022-04839-0

APA

Hemady, C. L., Speyer, L. G., Murray, A. L., Brown, R. H., Meinck, F., Fry, D., Do, H., Sikander, S., Madrid, B., Fernando, A., Walker, S., Dunne, M., Foley, S., Hughes, C., Osafo, J., Baban, A., Taut, D., Ward, C. L., Van Thang, V., ... Eisner, M. (2022). Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. BMC Pregnancy and Childbirth, 22(1), 505. Article 505. https://doi.org/10.1186/s12884-022-04839-0

Vancouver

Hemady CL, Speyer LG, Murray AL, Brown RH, Meinck F, Fry D et al. Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. BMC Pregnancy and Childbirth. 2022 Jun 22;22(1):505. 505. doi: 10.1186/s12884-022-04839-0

Author

Hemady, Chad Lance ; Speyer, Lydia Gabriela ; Murray, Aja Louise et al. / Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers : a latent class analysis. In: BMC Pregnancy and Childbirth. 2022 ; Vol. 22, No. 1. pp. 505.

Bibtex

@article{e2e04315f21d40a48c62b2426d09f83d,
title = "Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis",
abstract = "BACKGROUND: This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs).METHODS: A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed.RESULTS: Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes.CONCLUSION: Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges.",
keywords = "Adverse childhood experiences, Intergenerational transmission of adversity, Latent class analysis, Maternal health, Neonatal health, Prenatal substance use",
author = "Hemady, {Chad Lance} and Speyer, {Lydia Gabriela} and Murray, {Aja Louise} and Brown, {Ruth Harriet} and Franziska Meinck and Deborah Fry and Huyen Do and Siham Sikander and Bernadette Madrid and Asvini Fernando and Susan Walker and Michael Dunne and Sarah Foley and Claire Hughes and Joseph Osafo and Adriana Baban and Diana Taut and Ward, {Catherine L} and {Van Thang}, Vo and Pasco Fearon and Mark Tomlinson and Sara Valdebenito and Manuel Eisner",
year = "2022",
month = jun,
day = "22",
doi = "10.1186/s12884-022-04839-0",
language = "English",
volume = "22",
pages = "505",
journal = "BMC Pregnancy and Childbirth",
issn = "1471-2393",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers

T2 - a latent class analysis

AU - Hemady, Chad Lance

AU - Speyer, Lydia Gabriela

AU - Murray, Aja Louise

AU - Brown, Ruth Harriet

AU - Meinck, Franziska

AU - Fry, Deborah

AU - Do, Huyen

AU - Sikander, Siham

AU - Madrid, Bernadette

AU - Fernando, Asvini

AU - Walker, Susan

AU - Dunne, Michael

AU - Foley, Sarah

AU - Hughes, Claire

AU - Osafo, Joseph

AU - Baban, Adriana

AU - Taut, Diana

AU - Ward, Catherine L

AU - Van Thang, Vo

AU - Fearon, Pasco

AU - Tomlinson, Mark

AU - Valdebenito, Sara

AU - Eisner, Manuel

PY - 2022/6/22

Y1 - 2022/6/22

N2 - BACKGROUND: This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs).METHODS: A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed.RESULTS: Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes.CONCLUSION: Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges.

AB - BACKGROUND: This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs).METHODS: A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed.RESULTS: Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes.CONCLUSION: Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges.

KW - Adverse childhood experiences

KW - Intergenerational transmission of adversity

KW - Latent class analysis

KW - Maternal health

KW - Neonatal health

KW - Prenatal substance use

U2 - 10.1186/s12884-022-04839-0

DO - 10.1186/s12884-022-04839-0

M3 - Journal article

C2 - 35733125

VL - 22

SP - 505

JO - BMC Pregnancy and Childbirth

JF - BMC Pregnancy and Childbirth

SN - 1471-2393

IS - 1

M1 - 505

ER -