Home > Research > Publications & Outputs > Patterns of divergence in the vCXCL and vGPCR g...

Research

Links

Text available via DOI:

Keywords

View graph of relations

Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. / Alcendor, Donald J; Zong, Jianchao; Dolan, Aidan et al.
In: Virology, Vol. 395, No. 1, 05.12.2009, p. 21-32.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Alcendor, DJ, Zong, J, Dolan, A, Gatherer, D, Davison, AJ & Hayward, GS 2009, 'Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes', Virology, vol. 395, no. 1, pp. 21-32. https://doi.org/10.1016/j.virol.2009.09.002

APA

Alcendor, D. J., Zong, J., Dolan, A., Gatherer, D., Davison, A. J., & Hayward, G. S. (2009). Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. Virology, 395(1), 21-32. https://doi.org/10.1016/j.virol.2009.09.002

Vancouver

Alcendor DJ, Zong J, Dolan A, Gatherer D, Davison AJ, Hayward GS. Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. Virology. 2009 Dec 5;395(1):21-32. doi: 10.1016/j.virol.2009.09.002

Author

Alcendor, Donald J ; Zong, Jianchao ; Dolan, Aidan et al. / Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. In: Virology. 2009 ; Vol. 395, No. 1. pp. 21-32.

Bibtex

@article{80900e4400b94da5b61c8c495bd7b513,
title = "Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes",
abstract = "Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two, three and six genes, and the vGPCR cluster contains two, two and five genes. We report that (i) green monkey CMV strains fall into two groups, containing either eight and five genes or seven and six genes in the respective clusters, and (ii) owl monkey CMV has two and zero genes. Phylogenetic analysis suggested that the vCXCL cluster evolved from a CXCL chemokine gene (probably GRO-alpha) that was captured in an incompletely spliced form by an ancestor of Old and New World primate CMVs, and that the vGPCR cluster evolved from a GPCR gene captured by an Old World primate CMV. Both clusters appear to have evolved via complex duplication and deletion events.",
keywords = "Amino Acid Sequence, Animals, Cell Line, Chemokines, CXC, Cytomegalovirus, Evolution, Molecular, Gene Duplication, Genes, Viral, Genome, Viral, Humans, Molecular Sequence Data, Multigene Family, Phylogeny, Primates, Receptors, G-Protein-Coupled, Sequence Alignment",
author = "Alcendor, {Donald J} and Jianchao Zong and Aidan Dolan and Derek Gatherer and Davison, {Andrew J.} and Hayward, {Gary S.}",
year = "2009",
month = dec,
day = "5",
doi = "10.1016/j.virol.2009.09.002",
language = "English",
volume = "395",
pages = "21--32",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes

AU - Alcendor, Donald J

AU - Zong, Jianchao

AU - Dolan, Aidan

AU - Gatherer, Derek

AU - Davison, Andrew J.

AU - Hayward, Gary S.

PY - 2009/12/5

Y1 - 2009/12/5

N2 - Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two, three and six genes, and the vGPCR cluster contains two, two and five genes. We report that (i) green monkey CMV strains fall into two groups, containing either eight and five genes or seven and six genes in the respective clusters, and (ii) owl monkey CMV has two and zero genes. Phylogenetic analysis suggested that the vCXCL cluster evolved from a CXCL chemokine gene (probably GRO-alpha) that was captured in an incompletely spliced form by an ancestor of Old and New World primate CMVs, and that the vGPCR cluster evolved from a GPCR gene captured by an Old World primate CMV. Both clusters appear to have evolved via complex duplication and deletion events.

AB - Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two, three and six genes, and the vGPCR cluster contains two, two and five genes. We report that (i) green monkey CMV strains fall into two groups, containing either eight and five genes or seven and six genes in the respective clusters, and (ii) owl monkey CMV has two and zero genes. Phylogenetic analysis suggested that the vCXCL cluster evolved from a CXCL chemokine gene (probably GRO-alpha) that was captured in an incompletely spliced form by an ancestor of Old and New World primate CMVs, and that the vGPCR cluster evolved from a GPCR gene captured by an Old World primate CMV. Both clusters appear to have evolved via complex duplication and deletion events.

KW - Amino Acid Sequence

KW - Animals

KW - Cell Line

KW - Chemokines, CXC

KW - Cytomegalovirus

KW - Evolution, Molecular

KW - Gene Duplication

KW - Genes, Viral

KW - Genome, Viral

KW - Humans

KW - Molecular Sequence Data

KW - Multigene Family

KW - Phylogeny

KW - Primates

KW - Receptors, G-Protein-Coupled

KW - Sequence Alignment

U2 - 10.1016/j.virol.2009.09.002

DO - 10.1016/j.virol.2009.09.002

M3 - Journal article

C2 - 19818982

VL - 395

SP - 21

EP - 32

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -