Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

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Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. / Smith, Craig J.; Emsley, Hedley C. A.; Gavin, Carole M. et al.
In: BMC Neurology, Vol. 4, 2, 15.01.2004.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Smith, CJ, Emsley, HCA, Gavin, CM, Georgiou, RF, Vail, A, Barberan, EM, del Zoppo, GJ, Hallenbeck, JM, Rothwell, NJ, Hopkins, SJ & Tyrrell, PJ 2004, 'Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome', BMC Neurology, vol. 4, 2. https://doi.org/10.1186/1471-2377-4-2

APA

Smith, C. J., Emsley, H. C. A., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., del Zoppo, G. J., Hallenbeck, J. M., Rothwell, N. J., Hopkins, S. J., & Tyrrell, P. J. (2004). Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurology, 4, Article 2. https://doi.org/10.1186/1471-2377-4-2

Vancouver

Smith CJ, Emsley HCA, Gavin CM, Georgiou RF, Vail A, Barberan EM et al. Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurology. 2004 Jan 15;4:2. doi: 10.1186/1471-2377-4-2

Author

Smith, Craig J. ; Emsley, Hedley C. A. ; Gavin, Carole M. et al. / Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. In: BMC Neurology. 2004 ; Vol. 4.

Bibtex

@article{52545c3474e9402fbf89bdb991adce4a,

title = "Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome",

abstract = "Background: Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods: Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results: Peak plasma IL-6 concentration correlated significantly (p <0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma Creactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions: These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.",

keywords = "C-reactive protein, Inflammation, Interleukin-6, Outcome measures, Stroke acute",

author = "Smith, {Craig J.} and Emsley, {Hedley C. A.} and Gavin, {Carole M.} and Georgiou, {Rachel F.} and Andy Vail and Barberan, {Elisa M.} and {del Zoppo}, {Gregory J.} and Hallenbeck, {John M.} and Rothwell, {Nancy J.} and Hopkins, {Stephen J.} and Tyrrell, {Pippa J.}",

year = "2004",

month = jan,

day = "15",

doi = "10.1186/1471-2377-4-2",

language = "English",

volume = "4",

journal = "BMC Neurology",

issn = "1471-2377",

publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

AU - Smith, Craig J.

AU - Emsley, Hedley C. A.

AU - Gavin, Carole M.

AU - Georgiou, Rachel F.

AU - Vail, Andy

AU - Barberan, Elisa M.

AU - del Zoppo, Gregory J.

AU - Hallenbeck, John M.

AU - Rothwell, Nancy J.

AU - Hopkins, Stephen J.

AU - Tyrrell, Pippa J.

PY - 2004/1/15

Y1 - 2004/1/15

N2 - Background: Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods: Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results: Peak plasma IL-6 concentration correlated significantly (p <0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma Creactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions: These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.

AB - Background: Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods: Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results: Peak plasma IL-6 concentration correlated significantly (p <0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma Creactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions: These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.

KW - C-reactive protein

KW - Inflammation

KW - Interleukin-6

KW - Outcome measures

KW - Stroke acute

U2 - 10.1186/1471-2377-4-2

DO - 10.1186/1471-2377-4-2

M3 - Journal article

C2 - 14725719

AN - SCOPUS:2642581809

VL - 4

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

M1 - 2

ER -

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