Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein
AU - Zhao, Zongxi
AU - Zhou, Jiayan
AU - Shi, Anye
AU - Wang, Jingyi
AU - Li, Hongzheng
AU - Yin, Xiangjun
AU - Gao, Jialiang
AU - Wu, Ying
AU - Li, Jinlin
AU - Sun, Ya Xuan
AU - Yan, Hao
AU - Li, Yige
AU - Chen, Guang
PY - 2024/12/5
Y1 - 2024/12/5
N2 - Unhealthy biological aging is related to higher incidence of varied age-related diseases, even higher all-cause mortality. Previous small sample size study suggested that Per- and poly-fluoroalkyl substances (PFAS) was associated with biological aging, but the evidence of exposure-response relationships, potential effect modifiers, and potential mediators were not investigated. Therefore, we conducted a cross-sectional analysis of national study including 14, 865 adults in the US from 8 survey cycles of NHANES from 2003 to 2018, to investigate the associations of PFAS compounds in body serum, including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS), with biological aging. Generalized linear models showed that higher human exposure to PFAS was associated with accelerated biological aging. Importantly, human exposure to PFOA, PFOS, PFNA, and PFHxS with detected level (above 0.10ng/mL) was associated with an average of 3.3 year (95CI 2.7 to 3.9, P
AB - Unhealthy biological aging is related to higher incidence of varied age-related diseases, even higher all-cause mortality. Previous small sample size study suggested that Per- and poly-fluoroalkyl substances (PFAS) was associated with biological aging, but the evidence of exposure-response relationships, potential effect modifiers, and potential mediators were not investigated. Therefore, we conducted a cross-sectional analysis of national study including 14, 865 adults in the US from 8 survey cycles of NHANES from 2003 to 2018, to investigate the associations of PFAS compounds in body serum, including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS), with biological aging. Generalized linear models showed that higher human exposure to PFAS was associated with accelerated biological aging. Importantly, human exposure to PFOA, PFOS, PFNA, and PFHxS with detected level (above 0.10ng/mL) was associated with an average of 3.3 year (95CI 2.7 to 3.9, P
U2 - 10.1016/j.jhazmat.2024.136090
DO - 10.1016/j.jhazmat.2024.136090
M3 - Journal article
VL - 480
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
SN - 0304-3894
M1 - 136090
ER -