Western lifestyles and urbanisation have led many people to spend most of their time indoors. Existing studies have described the impact of indoor air quality (IAQ) on health and well-being. However, IAQ assessments typically focus on home or office settings. Hybrid working and a change in transport behaviour raise the question of what are the new trends of personal exposure to air pollution among all daily activities including home, office and transport. This study discusses the results from IAQ monitoring in everyday life of UK hybrid workers. It uses a personal air quality monitor to track daily activities to measure trends of personal exposure to air pollutants and identify spot-events of high exposure. The results present the diurnal and spatial variation of five indoor air pollutants: PM1, PM2.5, PM10, NO2 and VOC. Data was collected at 1-minutes intervals in an open plan office, a house with a small home office but also during the commuting between Glasgow (Scotland) and Lancaster (North West England) by train and between Lancaster and Southampton (South England) by car at different times of the day and traffic conditions. The findings discuss hybrid workers' spatiotemporal personal exposure trends to air pollutants and contextualise them to short- and long-term health risks. The paper concludes with recommendations to minimise personal exposure to indoor and outdoor air pollutants and mitigate health risks by identifying “high risk” activities in spatiotemporal relation to air pollutants.